🔥 Would like to share few slides of my talk on FIBRILLARY GLOMERULONEPHRITIS at ISNCON23 in Kolkata @isn_india @isncon23 @GlomCon #nephtwitter @JasmineNephro @nephromythri @drshyambansal @VijayKher8 @AnandhUrmila
🔥 🧵 long thread alert but it’s going to be equally colourful 💚💛💜 and black and white 🖤
✅ its a rare disease : less than 1 % of all biopsies
✅ Proteinuria , Haematuria and Renal dysfunction are the triad 🔺
✅ 🌗 half end up in ESRD
✅ Fibrillary GN teaches us how to study a rare disease : Multi-institutional cohorts
✅ average creatinine : 2.7 mg/ dl
✅ average proteinuria : 6.5 gram/ day
✅ Haematuria seen in 90 % patients
✅ Autoimmune disease, Hepatitis C are associations
🔥 Points on transplant immunology by Prof. Dr. Jeremy Chapman
🔥 the Complement dependent cytotoxicity (CDC) test
🔥 Donor lymphocytes + recipient sera + compliment
🔥 the cells which die due to complement mediated cytotoxicity via recipient antibody binding to donor HLA allow the dye to enter inside and gives itself a red colour
🔥 flow cross match
🔥 Gating of Lymphocytes —> labelling to B and T lymphocyte —> Flouroscein isthiocyanate labelled anti human Immunoglobulin