Jithu Kurian🇮🇳 Profile picture
Jun 14 25 tweets 9 min read Twitter logo Read on Twitter
🔥 Let’s discuss an interesting case . Already discussed in #ECNeph . Trying to consolidate it.

🏥 I was called in for a nephrology consult for a patient admitted under pulmonology 🫁

🩸 Microscopic hematuria ++ Image
🧠 What do we think in a patient with hemoptysis? Image
🫘 The nephrologist brain in me thought it narrower. The first hit Image
🧪 what does the lab has to say ?

Numerous 🩸red blood cells in urine and pulmonary haemorrhage .

💡I was sure i hit the right diagnosis 🎯 Image
📺 how can a nephrologist proceed without an Ultrasound kidney

✅Nothing significant Image
🫘 Now its nephrology time to crack the case .

🛏️ Patient got re admitted

💦 oliguric renal failure ImageImage
✌️ What is the clinical diagnosis ? Image
🚨🚨 PR3 ANCA , MPO ANCA Anti GBM - Negative, C3 - Normal

🟢 I told it could still be ANCA negative Paucimmune crescentic GN with pulmonary haemorrhage

❓What next ? Seeing is believing

💊 Empirical steroids Image
🔫 renal biopsy report 😳😳

😨 quite unexpected ImageImage
🚨 when things don’t go the way you think its not a bad idea to go back to the patient and the previous reports Image
🤯 Rechecking the reports

🎯🎯 We got down to the diagnosis at the end ✌️✌️ ImageImage
🧐🧐 but there is a problem 🚨 Image
🌞 We went ahead with CT Angio —> the CT revelation 👌 ImageImage
📈Let’s see how the disease progressed 🔴🔴 ImageImage
🔖 what’s the status of the patient ? Image
🌞 what could be the reason for renal vein thrombosis ? Image
🔃 when in doubt get back to the patient and old reports

💡 atypical cells within the lung biopsy —> slide sent for IHC ImageImage
🚨🚨 The suspected trouble maker Image
🥇 The final diagnosis Image
🧭 Approach to rapidly progressive renal failure

🩸 Never forget the vascular cause of RPRF ImageImage
🚨 RPRF with normal renal biopsy Image
🩸 Causes and symptoms of RVT ImageImage
📌 evaluation and treatment of Renal vein thrombosis ImageImage
⚠️ Do we neglect renal cysts ? ImageImage
📌 The CT classification of cysts and the chances of them being problematic ImageImage

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More from @Jithukurian6

Apr 28
🔥 Points on transplant immunology by Prof. Dr. Jeremy Chapman Image
🔥 the Complement dependent cytotoxicity (CDC) test

🔥 Donor lymphocytes + recipient sera + compliment

🔥 the cells which die due to complement mediated cytotoxicity via recipient antibody binding to donor HLA allow the dye to enter inside and gives itself a red colour ImageImage
🔥 flow cross match

🔥 Gating of Lymphocytes —> labelling to B and T lymphocyte —> Flouroscein isthiocyanate labelled anti human Immunoglobulin Image
Read 8 tweets
Apr 28
What i learnt today at #ApexPathshala second day of amazing talks and interactions

Immunosuppressive protocol by prof Dr S k Agarwal and Prof Dr. Jeremy chapman

🔥 the ⏰ timeline of drug development ImageImage
🔥 few ♥️ cardinal points of immunosuppression Image
🔥 risk stratification of patients in renal transplant at AIIMS 🏥

🔥when do you call a patient immunologically high risk ? 🔴 ImageImage
Read 6 tweets
Feb 14
🔥Had a small presentation (12 min ) on Rituximab in ANCA vasculitis . Few things I learnt while making it
🔥How do we know that B lymphocytes play a prominent role in pathogenesis of ANCA vasculitis ?
🔥 how does the CD 20 receptor - the site of action of Rituximab look like ?

🔥 what does the xi in Rituximab stand for ?

🔥 what’s the target CD 19 cell count we target for ?
Read 22 tweets
Aug 8, 2020
Hi every one , once again back with nephrotic syndrome

What is steroid dependent nephrotic syndrome ? 🤔🤔

Its two 2⃣ s

2⃣ consecutive relapses while on steroid therapy or

within 2⃣ weeks of stopping steroids
What are the steroid sparing agents in steroid dependent nephrotic syndrome in children 👶? 🤔🤔

👉🧨I always had difficulty in getting this numbers right as a resident 🤫🤫 so , lets revise 😀
👉 Oral cyclophosphamide💊➡️2.5 mg /kg / day for 8 -12 weeks

👉 To be given only after remission with steroids is
attained

👉Not to be repeated for the second time 💊💊❌

👉 Max cumulative dose – 168 mg/kg 💀

👉Better response for frequent relapse than in steroid dependent
Read 7 tweets

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