Emmanuel Profile picture
Jun 16 7 tweets 4 min read Twitter logo Read on Twitter
The SILENT PANDEMIC: Emergent ANTIBIOTIC RESISTANCES following the global response to SARS-CoV-2

SUMMARY :
The overuse and misuse of antibiotics during the pandemic may lead to the development of resistant bacterial strains. This is particularly concerning as ... Image
2) ... antibiotic resistance is a growing global threat and could lead to a silent pandemic that is just as deadly as COVID-19. The study emphasizes the need for appropriate use of antibiotics and the development of new antimicrobial therapies to combat emerging resistant strains Image
4) Fig. Antimicrobial resistance and COVID-19 mortalities Image
5) Fig. Antibiotic therapeutic resistance and bacterial co-infections Image
6) DISCUSSION
The increased use of antibiotic therapeutics during this pandemic is anticipated to result in the rapid emergence of novel, deadly, AMR pathogens. This crisis will only be mitigated by an active communication to the public about the risk of these infections Image

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More from @ejustin46

Jun 17
PROTEIN-PROTEIN interaction DRUG DISCOVERY

We have often talked in different threads about the action of such and such proteins (spike, envelope, ORFs, NSPs, ...) or mutations within these proteins and their impact. More and more researchers are working also on the interactions Image
2) ... between these proteins . These interactions are represented in a "map" called a "interactome" representing the proteome, a complete set of proteins made by an organism.
To illustrate the complexity of this research we would first like to show some examples of interactomes Image
3) Example of Interactome (1)
nature.com/articles/s4158… Image
Read 7 tweets
Jun 17
"Epidemiological drivers of transmissibility and severity of SARS-CoV-2 in England"

The epidemiological drivers of transmissibility and severity of SARS-CoV-2 in England can be influenced by a range of factors, including the level of community transmission, Image
2) the effectiveness of public health measures, the virulence of the virus, and the susceptibility of the population

Study :
medrxiv.org/content/10.110…
3) Population-level transmission of SARS-CoV-2 between March 2020 and February 2022 in England Image
Read 5 tweets
Jun 17
"Inflammatory profiles are associated with long COVID up to 6 months after illness"

SUMMARY
This study suggests that individuals with long COVID experience persistent inflammation up to 6 months after their initial illness, regardless of the severity of their COVID-19 symptoms. Image
2) This inflammation can affect multiple organs in the body, leading to a range of symptoms. It also emphasizes the importance of preventive measures to reduce the risk of COVID-19 infection, as even mild cases can lead to long-term health problems.
medrxiv.org/content/10.110…
3) Log-concentrations of inflammatory markers at 9-12 and 21-24 weeks after Illness onset among RECOVERED study participants with and without PASC Image
Read 4 tweets
Jun 16
RETURN TO THE ORIGINS OF OMICRON!
(Unique Spike Gene Insertion)

SUMMARY
The unique spike gene insertion found in the Omicron variant of COVID-19 has raised questions about its origin as its precise origins are not yet fully understood. Genetic sequencing of Omicron has revealed Image
2) ... that it contains numerous mutations, including changes to the spike protein that make it more infectious or resistant to vaccines."

STUDY
ncbi.nlm.nih.gov/pmc/articles/P… Image
3) In this study, they provide several plausible hypotheses on the origins of a nine-nucleotide insertion in the N-terminal domain of the Spike protein of the initially identified Omicron BA.1 variant. Image
Read 7 tweets
Jun 16
GOOD VENTILATION in SCHOOLS = LESS ILLNESS related ABSENCES !

Study monitored indoor data in 144 classrooms in 31 schools in the Midwestern for 2 consecutive days every fall, winter, and spring during 2 years; 3,105 pupils attended classrooms where measurements were conducted. Image
3) RESULTS
Every 1 L/s per person increase in ventilation rate and every additional 1 µg/m³ of 3 indoor PM2.5 were associated with a 5.59 decrease and a 7.37 increase in days with absences per year. Image
Read 4 tweets
Jun 15
COVID-19 IMPACT ON THE BRAIN and WHITE MATTER

DTI is a type of magnetic resonance imaging (MRI) that measures the diffusion of water molecules in tissues. It can provide information about the microstructure of white matter, such as the integrity of myelin and axonal fibers. Image
2) Both DTI and CDI have been used to study various neurological and psychiatric disorders, including Alzheimer's disease, and schizophrenia and have also been applied to investigate the effects of COVID-19 on the brain, as the virus has been shown to cause neurological symptoms
3) In the study, this approach helps to uncover opposing patterns of diffusion changes in the frontal and cerebellar regions of COVID-19 patients, suggesting the two regions react differently to viral infection.
onlinelibrary.wiley.com/doi/full/10.10… Image
Read 5 tweets

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