This is the anedoctal tale of six rapid antigen covid tests (RAT) from four different brands taken by the same person, within a 2 hour time period and how the results were quite diverse. It reinforces that a negative RAT doesn't mean a person isn't infected. Act accordingly. 1/
The tests were taken in order from left to right: A B A B C D. Each letter represents a different brand. The A tests are positive, the Bs negative, C and D are ver faint positives (the C + is extremely faint but is there). 2/
The tests were done because the result of the first was an unexpected and undesired surprise. After the first positive, we did a counter test that was negative, which led to a repetition of these tests from the same brands, confirming the previous results.
3/
These results were also a surprise because I have used the Panbio test since September 2020 and had the opportunity to cross check with PCR tests on different occasions and was very happy with its performance. But here it was outperformed by cheaper alternatives. 4/
The FlowFlex test by Acon Biotech had the best result. It was able to give clear positive results in someone virtually assymptomatic, at the start of infection. It is the most widely available and cheapest test here in Portugal at the moment, so it's good to see it perform.
5/
It was also a surprise that tests with short, thick swabs (A/D) outperformed tests with long thin swabs (B/C). I've preferred long thin swabs because they allow sampling the throat and go deeper in the nasal cavity. But here, the short swabs used in the nose alone did better. 6/
Maybe the short swabs absorbed more material from what must have been the shedding area at that moment. Or maybe the tests have different sensitivities for the current circulating strains. I don't know for sure. But the negative results from a trusted test were an eye opener.
7/
I have in the past made risk assessments based on negative RATs that I would now feel less confortable with. It's true that these RAT results likely mean the person wasn't very infectious then. And RATs are an extremely useful tool that allow decisions to be made in real time.
8/
But one can become over confident with negative RATs. So, if the RAT negative result disagrees with the person symptoms or risk contact, don't make decisions based on RAT alone. As in this case, RATs can produce false negatives, so always interpret a negative result with care.
9/
And don't be shy in using different brands at the same time when testing. As it was the case here, if we had used the Panbio alone we would't had isolated as early as we did. And that early isolation could have made the difference between getting infected or not.
10/
This has been a valuable lesson for us. Buy tests from different brands and test generously. And remember to integrate the test result with all the other information you have - symptoms and time from previous risk exposure - before making risk assessment decisions.
(End) 11/11
It should be said that the swab was used in both nostrils and inserted almost completely in at least one of the nostrils, and very thoroughly circled before performing the test.
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So, today I'm feeling angry. I guess I went through the denial stage by going into a frenetic spell, buying all the stuff (groceries, medication) needed for our separate isolation, going through the great advice I got from so many of you...
1/
but today my partners infection became much more symptomatic (we really caught it at the start) and knowing someone you love is sick with a preventable infection with potential serious outcomes because virtually noone anymore gives a flying monkey about Covid got me worked up. 2/
From the start of the pandemic I've been trying to have everyone's back. I shouted warnings, I was the guy on the phone for anyone and everyone with questions, I made graphs, I tried to dispell myths and lies about this disease, I drove to test people. And I haven't stopped. 3/
Are all infections born equal? Is getting infected while using a good mask the same as getting infected with no mask? NO!
The size of the inoculum makes a big difference!
Getting infected with a larger viral load (inoculum) is worse than getting infected with a smaller one!
1/
Every infection leads to a battle between exponential growth curves of the viral particles on one hand and the immune cells on the other. And the starting point makes a difference to the time needed for the immune system to get the best of the virus.
2/
The larger the inoculum, the higher the peak viral load will be, the sicker the person will be, the longer it takes to clear the infection and most likely the higher the chances for chronic illness/infection to establish. The smaller the inoculum, it's the other way around!
3/
It looks like I might be losing my COVID virginity the next couple of days. My lifepartner, a teacher, just tested positive (second infection, almost exactly a year after the first). We both do close to everything outside home with a ffp2 on. We are EXTREMELY careful. But...
1/
...teachers have much less control since virtually noone is still masking in schools.
Test last night was negative. This morning it was a very faint positive.
The year before we had been apart before the positive test. So this is very likely my highest exposure so far.
2/
Still, we caught it right at the start. Maybe I'll get through without getting infected. Maybe.
But it is no fun watching those you love getting infected, specially when we go to such great lenghts to avoid getting it or giving it to others.
3/
Another COVID-19 alarm bell is being toned down, this time by the European Mortality Monitoring Project (EuroMOMO). Mortality data from Spring 2023 onwards has started being incorporated in the baseline used to calculate Excess Mortality, making the pandemic the new 'normal'. 1/
This time the approach is less radical than the UK Office of National Statistics one (see below): they are not including 2021 or 2022 or the winter of 2023. But the rational is the same: make the pandemic mortality the new 'normal'. 2/
It is a reality that as the pandemic drags on, the use of the pre-pandemic 5 years of 2015-2019 for the mortality baseline brings with it increasing biases. But it is intelectually dishonest to claim that mortality is now back to baseline based on a single time period. 3/
The North Atlantic Sea Surface Temperature Anomaly is beyond anything registered before. This will feed into the whole system entropy.
The Antarctic Sea Ice Anomaly is also recording never seen low levels, increasing light absorption by the sea surface which will feed into a positive feedback mechanism.
One more day, one more patient with post-Covid bloodwork that shows low numbers of Neutrophiles, one of the white blood cells responsible for our immunity. They are normally the most abundant type of white blood cell, defending us from invasion by pathogens like bacteria. 1/
This person COVID infection was 7 months prior to the results.
I am seing an increase in these low levels of neutrophiles, a condition we name neutropenia.
2/
The drops in neutrophile numbers correlates with the growing reports of increasing incidence and severity of bacterial infections like Strep throat and invasive fungal infections like Candida and Aspergillus.
3/