charlos Profile picture
Jun 21 13 tweets 4 min read Twitter logo Read on Twitter
New study:

“The #LongCovid patient showed clear differences in the ventilated area compared to control subject.. uneven distribution of ventilation dominated the findings… a chest CT did not show pathological findings”
link.springer.com/article/10.100…
“Many #LongCovid patients suffer from dyspnea on exertion. To visualize exercise-induced dyspnea, a post-COVID patient and a healthy volunteer underwent an exercise test on a treadmill under stress relevant to everyday life monitored by electrical impedance tomography (EIT).”
“EIT is suitable for visualizing disturbed ventilation of the lungs, both at rest and under stress. The potential as a diagnostic tool in dyspnea assessment should be investigated”
“Electrical impedance tomography (EIT) radiation-free, non-invasive method to visualize lung ventilation. Our.. group has shown EIT can detect pathologies in #LongCovid patients. However, findings at rest can be misleading, as some pathologies only become visible on exertion.”
“Furthermore.. pulmonary function tests were normal in many #LongCovid patients, when comparing symptomatic & non-symptomatic post-COVID patients, no differences found.. Therefore we decided develop a suitable exercise test to visualize ventilatory deficits in post-COVID patient”
“The #LongCovid patient showed an even ventilation situation at rest..
During exercise, ventilated areas differed constantly. However, especially in anterior regions larger areas were partially absent from ventilation. The entire lung area was now affected by oscillating air.”
“The patient was exhausted after examination, agreed that this was a stress relevant to everyday life and was satisfied with the examination procedure.”
“To our knowledge, this is the first visualization of exercise-induced dyspnea in a #LongCovid patient using EIT. We demonstrate that using EIT under exercise is feasible and, therefore, is a potential tool to investigate exercise-induced dyspnea.”
“The question of EIT being pathologic remains unexplained.. underlying cause may be increased anaerobic metabolism, reflected in high post-exercise lactate & reduced peak oxygen uptake. Moreover, altered autoimmune dysfunction.. endothelial dysfunction, tissue damage” #LongCovid
“Furthermore, the difficulty of imaging this respiratory distress should be noted. For example, only about 20% of #LongCovid patients showed a pathology on CT or pulmonary function test at rest”
“EIT as a radiation-free, non-invasive and cost-effective method is suitable for visualizing a disturbed ventilation of the lungs, both at rest and under stress. The potential as a diagnostic tool in assessment of dyspnea should be investigated.” #LongCovid
So many of us with #LongCovid have chronic debilitating dyspnea with completely normal CT, PFT & DLCO.. desperately need new diagnostic to identify these perfusion issues found in XE MRI, EIT, etc.

This is not typical lung damage or airway inflammation — need new diagnostics.
H/t @biotechbuzznews great newsletter — high recommend!

• • •

Missing some Tweet in this thread? You can try to force a refresh
 

Keep Current with charlos

charlos Profile picture

Stay in touch and get notified when new unrolls are available from this author!

Read all threads

This Thread may be Removed Anytime!

PDF

Twitter may remove this content at anytime! Save it as PDF for later use!

Try unrolling a thread yourself!

how to unroll video
  1. Follow @ThreadReaderApp to mention us!

  2. From a Twitter thread mention us with a keyword "unroll"
@threadreaderapp unroll

Practice here first or read more on our help page!

More from @loscharlos

Jun 20
The moment you start withholding information from the public during a pandemic — such as deliberately suppressing the reality & risk of #LongCovid — Is the moment you open the floodgates for bad actors to spread dangerous misinformation.

At that point — you’ve lost all trust.
So when people are confronted with reality of #LongCovid but realize they are not hearing this information from the public health authorities who swore to inform them —

It creates an incident of exposure, & folks become susceptible to conspiracy narratives about other topics.
If they were lying to us about risk of infection how do we know they are not lying to us about XYZ?

How do I know whether scientific community can be trusted or Joe Rogan off his rocker?

At that point you cannot corroborate “following the science” & current public health policy
Read 6 tweets
Jun 9
“The phase 3 trial — considered the gold standard in research — revealed that metformin could reduce the risk of #LongCovid by up to 63% among participants who started treatment within four days of their initial COVID diagnosis.” sfchronicle.com/health/article…
“The results of the first clinical trial of its kind were striking: Across entire pool of participants, individuals who received a two-week course of metformin while battling their infection were 42% less likely to develop #LongCovid than those who received an identical placebo”
“The impact of metformin — which costs around $11 for a supply of 14 tablets — was consistent across diverse demographic populations and multiple viral variants, including the prevalent omicron variant.” #LongCovid
Read 8 tweets
Jun 8
“If I didn’t have the support of my family, I’d be out on the streets,” he said. “[Insurers] are willing to let all the folks with #LongCovid who are currently suffering go without the benefits that are rightly owed to them.” kqed.org/news/11951994/…
“He eventually tried to return to work full-time, as the head of sales of a Bay Area start-up, but found it nearly impossible to get through the day.

Pham had to take medical leave, and was ultimately laid off.” #LongCovid
“I was passing out in the middle of the day after one or two meetings &.. trigger my #LongCovid symptoms. On calls, there was extreme fatigue & then this pain, like heavy sinking pain.. like someone attached a 50-pound anchor to your face & let it drop to the bottom of ocean”
Read 11 tweets
Jun 8
“Shockingly, our research has revealed #LongCovid can leave people with worse fatigue & quality of life than some cancers”

“Their health-related quality of life scores were lower than people with advanced metastatic cancers, such as stage 4 lung cancer”
theguardian.com/society/2023/j…
“Fatigue is the symptom with the greatest impact on the daily lives of #LongCovid patients.. They found that many were seriously ill and had fatigue scores worse than or similar to people with cancer-related anaemia or severe kidney disease.”
“Overall, the impact of #LongCovid on the daily activities of patients was worse than that for stroke patients and comparable to people with Parkinson’s disease.”
Read 6 tweets
Jun 5
New #LongCovid study:

"A new case-control study of Brazilian healthcare workers suggests.. multiple infections raised the risk."

"Multiple COVID infections were predictive of developing Long Covid."
cidrap.umn.edu/covid-19/study…
"Out of 7,051 HCWs diagnosed as having COVID-19, 1,933 (27.4%) who developed #LongCovid were compared to 5,118 (72.6%) who had a COVID-19–positive test but did not experience any symptoms at week 4."
"Overall, 887 HCWs (12.6%) had two or more SARS-CoV-2 infections, including 17.8% of cases and 10.6% of controls." #LongCovid
Read 5 tweets
May 30
"About 1 in 10 of the 110,000 people who catch COVID this week in the US, many for a second or third time, will be left lastingly ill. Even some vaccinated people; even some young, previously healthy people, after only mild cases." — @WesElyMD #LongCovid bostonglobe.com/2023/05/26/opi…
"COVID-19 is an ongoing mass disability event. Every seven days, 25,000 more people.. in our country suffering memory loss, heart problems.. extreme fatigue, and more owing to the virus. Globally an estimated 65 million people have this new chronic health condition." #LongCovid
"In a recent study from Sweden following #LongCovid patients out 2 years, more than 80%.. met diagnosis of #LongCovid at four months (& 1 in 3 of the total 460 COVID-19 patients tracked) still had ongoing cognitive, muscle, & fatigue symptoms affecting everyday life at 2 years."
Read 16 tweets

Did Thread Reader help you today?

Support us! We are indie developers!


This site is made by just two indie developers on a laptop doing marketing, support and development! Read more about the story.

Become a Premium Member ($3/month or $30/year) and get exclusive features!

Become Premium

Don't want to be a Premium member but still want to support us?

Make a small donation by buying us coffee ($5) or help with server cost ($10)

Donate via Paypal

Or Donate anonymously using crypto!

Ethereum

0xfe58350B80634f60Fa6Dc149a72b4DFbc17D341E copy

Bitcoin

3ATGMxNzCUFzxpMCHL5sWSt4DVtS8UqXpi copy

Thank you for your support!

Follow Us on Twitter!

:(