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A genetic risk factor for the development of #LongCovid!
A new study identified the first genome-wide significant association for #LongCOVID at the FOXP4 locus. 1/
A new study identified the first genome-wide significant association for #LongCOVID at the FOXP4 locus. 1/
#FOXP4 has been previously associated with COVID-19 severity, lung function, & cancers, suggesting a broader role for lung function in the pathophysiology of LongCOVID. 2/
When SARS-CoV-2 infection is required for COVID-19, and severe COVID-19, are all genetic variants that increase COVID-19 susceptibility or severity equally large risk factors for Long COVID? 3/
In this study, researchers aimed to answer this question through examining variant effect sizes between SARS-CoV-2 infection susceptibility, COVID-19 severity, and Long COVID. 4/
They discovered that the majority of variants affected only SARS-CoV-2 susceptibility or COVID-19 severity. In contrast, the FOXP4 variants had higher effect size for Long COVID than expected, suggesting an independent role of FOXP4 for Long COVID 5/
Such observation offers clues on biological mechanisms, such as #FOXP4 affecting pulmonary function and immunity, which then contribute to the development of Long COVID. 6/
Overall, the above study elucidates genetic risk factors for Long COVID, the relationship between Long COVID and severe COVID-19, and finally possible mechanisms of how FOXP4 contributes to the risk of Long COVID. 7/
medrxiv.org/content/10.110…
medrxiv.org/content/10.110…
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