Pediatrician, ‘rational’ vaccine thinker, Editor Covid Vaccines, TB on Vaccines & many others, Past-Convener IAP COI, Member-WHO-VSN https://t.co/eOvazlWmWg
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In this multicenter Italian study, researchers used nailfold videocapillaroscopy (NVC) to identify microvascular damage in Long COVID patients up to 18 months after infection. 2/ 
The activation and degranulation of mast cells (MCs), triggered by a variety of viruses, are intricately linked to viral pathogenesis. However, the precise mechanism underlying virus-induced MC degranulation remains largely unknown. 2/ 
MiR-126-3p plays a role in reducing blood vessel formation and reducing the severity of knee osteoarthritis, making it not just a signal of disease—but potentially a contributor to it. 2/ 
Over 90% of genes identified in the original study were also associated with #LongCOVID in the U.S. population including in Black and Hispanic groups. 2/
he two drugs were selected using artificial intelligence (AI) from over 5,400 proteins linked to LongCOVID, offering a promising shortcut to treatment by targeting 13 shared biological pathways. 2/ 
The widespread transmission of highly pathogenic avian H5N1 influenza, clade 2.3.4.4b, in wild and livestock mammals with isolated human cases has heightened concerns for zoonotic outbreak, necessitating vaccine readiness. 2/ 
The study, led by the University of Pennsylvania and part of the NIH’s RECOVER initiative, found kidney disease risks increased up to 35%, GI symptoms by up to 28%, and cardiovascular conditions like heart inflammation or arrhythmias by 63%. 2/ 
In preclinical testing, the compounds performed better than Paxlovid against SARS-CoV-2 and the Middle East Respiratory Syndrome (MERS) virus, which periodically causes deadly outbreaks around the world. 2/ 
Given the essential role of type I interferon in protective immunity against SARS2 & the association of chilblains with inherited type I interferonopathies, researchers hypothesized that excessive I-IFN responses to SARS2 might underlie the occurrence of chilblains 2/ 
Aberrant DNA methylation patterns have been linked to various diseases, including cancer and metabolic disorders. 
Norepinephrine is a major signaling factor in the brain and affects almost every cell type. In the context of neurodegenerative diseases such as Alzheimer's disease, it has been shown to be anti-inflammatory. 2/ 
Metformin impacts mitochondrial metabolism, & these pre-cancerous cells need this energy to keep growing. By blocking this process, researchers stop the cells from expanding & progressing towards AML, whilst also reversing other effects of mutated DNMT3A gene 2/ 
Presence of IgG4 & IgE in COVID-19 suggests that the virus may induce an “allergic-like” response to evade immune surveillance, leading to a shift from Th1 to Th2 cells, which promotes tolerance to the virus & potentially contributes to chronic infection & may be LongCovid 2/ 
It turns out that mitochondria can actually be transferred to other cells if needed. 
Spike protein exposure was studied in human embryonic stem cell-derived retinal organoids (hEROs) at various stages of retinal development. Immunofluorescence, RNA sequencing, and RT-PCR were used to determine how S protein exposure affects retinal development early and late 2/ 
A longstanding mystery in PD has been why some people carrying pathogenic variants that increase their risk of PD go on to develop the disease, while others who also carry such variants do not. The prevailing theory has suggested additional genetic factors may play a role 2/ 
Post-infection ACE2 and TMPRSS2 expression in the upper respiratory tract has been linked to increased disease severity among adults, and higher post-infection ACE2 expression has been linked to increased secondary transmission among adults,and risk of infection in children. 2/ 
The world-first study found mice treated with the antiviral compound, developed by a multidisciplinary research team at WEHI, institute were protected from long-term brain and lung dysfunction—key symptoms of long COVID. 2/ 
In order to steer the immune response away from RBD epitopes to more conserved domains, researchers generated S glycoprotein trimers without RBD and stabilized them by formaldehyde cross-linking. 2/ 
This was associated with increased Vascular Endothelial Growth Factor (VEGF) and Fibronectin expression, as well as structural changes in intercellular junctions between intestinal cells. 2/ 
Genetic surveillance has identified mutations that enhance H5N1's affinity for human upper respiratory cells, raising concerns that further adaptation or recombination with seasonal flu could significantly increase the risk of a pandemic. 2/ 