Pediatrician, ‘rational’ vaccine thinker, Editor Covid Vaccines, TB on Vaccines & many others, Past-Convener IAP COI, Member-WHO-VSN (https://t.co/eOvazlWULO)
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A research team explored immune pathways in the development, persistence and resolution of longCOVID, say sex-based differences—and similarities—not only emerged in their research, the findings have helped shed new light on long COVID and suggest new paradigms for treatment. 2/
The study explored the potential of #Dextromethorphan in the treatment of lung fibrosis. Lung fibrosis occurs after accumulation of scar tissue in the lung (Lt: a mice lung w/ scarring tissue) which was reduced after treatment w/ Dextromethorphan (Rt). 2/ 
Diet has been identified as a potential avenue for reducing dementia risk. Previous observational studies have linked anti-inflammatory diets, such as the Mediterranean, with slower cognitive decline and lower dementia risk. 2/ 
In recent clinical trials, two experimental RSV vaccines for babies may not only have failed to protect them, but actually made some of them sicker when they got RSV or another respiratory virus. 2/ 
Retinoic acid-inducible gene I (RIG-I) is a cytosolic viral RNA sensor critical for host antiviral defense against RNA virus infection, including SARS-CoV-2 and influenza. 2/ 
Researchers used data from the Long COVID in Children and Young People (CloCk) study to describe symptoms and how much they impact children and young people’s lives 24-months post-infection. 2/ 
Researchers used human pulmonary endothelial cells (HPAECs) expressing the ACE2 receptor as a model of the endothelium. This system mimics in vivo conditions, as it allows virus entry but not replication. 2/ 
The researchers conclude that spike protein is sufficient to induce brain pathological and behavioral changes in mice. 
#Benralizumab is a monoclonal antibody which targets eosinophils to reduce lung inflammation. The new trial has found a single dose can be more effective when injected at the point of exacerbation compared to steroid tablets. 2/ 
The SARS-CoV-2 virus spreads via mucus once inside an infected airway, allowing it to reach into the lower lungs 2/ 
Excess cholesterol is known to form artery-clogging plaques that can lead to stroke, arterial disease, heart attack, and more, making it the focus of many heart health campaigns. 2/ 
During the epidemic peak, the levels of DNA damage ranged from the highest to the lowest levels in the following groups, respectively: intubated-ICU, non-intubated-ICU, non-ICU, and influenza with a discernible increase in DNA damage in ICU-treated patients. 2/
Learning and memory are generally associated with brains and brain cells alone, but this study shows that other cells in the body can learn and form memories, too. 2/ 
Seniors and people with type 2 diabetes were even more strongly affected, experiencing an approximately two-fold increased risk for developing dyslipidemia, which is a major risk factor for cardiovascular diseases such as heart attack and stroke. 2/
Approximately 50% to 60% of adults experience NLCs (Charley horse) in their lifetime, w/ ~20% encountering significant distress and insomnia that lead them to seek medical intervention. 
Olfactory dysfunction, often dismissed as a minor inconvenience, may actually be an early sign of various neurological and bodily diseases, as indicated by this research. 2/ 
While most vaccines generate memory B-cells, not all of them turn into LLPC. Special signals from B-cell receptors required for this to happen. Cross-linking between these receptors (BCR cross-linking) & the antigen present in the vaccine triggers the T-cells help 2/ 
While studies have suggested that about a third of those moderately or severely infected are likely to suffer from long Covid, region-wise though, incidence could vary. 2/ 
The CoughFeatureRanker algorithm selects the most prominent features based on their optimal discriminatory performance from 15 features to detect COVID-19. 2/ 
Their findings, including preclinical studies in mice, introduce the Adaptive Multi-Epitope Targeting and Avidity-Enhanced (AMETA) Nanobody Platform, a new antibody approach for addressing how viruses like SARS-CoV-2 evolve to evade vaccines and treatments. 2/ 