Pediatrician, ‘rational’ vaccine thinker, Editor Covid Vaccines, TB on Vaccines & many others, Past-Convener IAP COI, Member-WHO-VSN (https://t.co/eOvazlWULO)
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This sneaky move weakens the immune cells, making them less effective at stopping the tumor. The findings could help explain why some cancer treatments, like immunotherapy, are effective for some patients but not others. 2/ 
On average, the effects were comparable to 4 years of aging with the greatest effects seen in those hospitalized with severe COVID-19 or with underlying risk factors for dementia such as smoking or high blood pressure. 2/ 
At first, these findings seemed to introduce a paradox: If scratching an itch is bad for us, why does it feel so good?
The women who were immune to the virus exhibited elevated expression of the gene IFIT3 (interferon-inducible protein with tetrapeptide repeats 3) compared with their male partners. 2/ 
1-Antibodies aren’t everything! 
The predominant symptom clusters among people with LC were fatigue/exhaustion, neurocognitive disturbances, chest symptoms/breathlessness & anxiety/depression/sleep problems. Nearly 68% of people who originally reported LC still struggled with symptoms in the second year. 2/ 
The treatment works by targeting one of the hallmarks of the ageing process: a stage called cellular senescence, in which cells lose their ability to replicate. 2/ 
While it is possible that the causes of long COVID could be many and variable depending on the patient population studied, with this cohort the evidence is clear that by having COVID numerous times, patients became more at-risk for developing LongCOVID. 2/ 
Although PASC aka #LongCovid has remained a multi-organ disease, it now predominantly affects nervous system. Indeed, the cognitive impairment of PASC was found to be of the same magnitude as alcohol intoxication at the UK/USA driving limit or 10 years of cognitive aging 2/ 
Furthermore, the city children, with no other risk factors for brain disorders, performed comparatively poorly on cognitive tasks. 2/
Using a cross-sectional analysis of 244 individuals, researchers applied multivariate analysis of variance, principal component analysis, and multinomial regression to examine the relationships between AAB levels and key symptoms. 2/ 
Cardiovascular involvement is frequently reported in LC, often accompanied by a spectrum of related symptoms. Dysregulated lipid profiles and elevated atherogenic indices have been implicated in LC. 2/ 
These findings, shown experimentally for the first time in human studies, reshape our understanding of how our immune system works, paving the way for the design of more effective vaccines. 2/ 
Infection with herpes simplex virus type 1 (HSV-1) is common, lifelong, and often in a latent state with periodic reactivation. It is a risk factor for neurodegenerative disease and dementia in some individuals, as are repeated head injuries like concussions. 2/ 
These results are at odds with recent research that has failed to show #Paxlovid can alleviate persistent symptoms of the disease. The researchers said more study is needed to find out which patients may benefit from the drug and how long it should be given. 2/ 
The finding — now from two studies — suggests that the antibodies are the cause of the long COVID symptoms.
By studying mice equipped w/ brain electrodes & tiny eye-tracking cameras, researchers find that new memories are being replayed & consolidated when pupil is contracted during a substage of non-REM sleep. When the pupil is dilated, the process repeats for older memories. 2/ 
By inducing chronic inflammation, immunosenescence, and neuroinflammation, COVID-19 may exacerbate the processes of neuroimmune aging, leading to increased risks of cognitive decline, neurodegenerative diseases, and impaired immune function. 2/ 
When researchers analyzed videos of children lying on their backs in what’s called General Movement Assessment, 14% of infants showed signs of developmental problems. The test evaluates early motor functions & is often used to assess the risk of neurodevelopmental disorders 2/ 
Cellular senescence occurs when cells stop dividing but do not trigger apoptosis mechanisms that would allow them to die naturally. 2/ 