Pediatrician, ‘rational’ vaccine thinker, Editor Covid Vaccines, TB on Vaccines & many others, Past-Convener IAP COI, Member-WHO-VSN (https://t.co/eOvazlWULO)
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As with its predecessor, the new drug candidate, Jun13296, targets a different viral protein than Paxlovid does and works alone rather than in combination with another drug called ritonavir. 2/ 
LP.8.1 was first detected in July 2024. It’s a descendant of Omicron, specifically of KP.1.1.3, which is descended from JN.1, a subvariant that caused large waves of COVID infections around the world in late 2023 and early 2024. 2/ 
Scientists often think they grasp a virus's anatomy, tricks, and body movement. But occasionally, we discover something unexpected that radically transforms how we view an infection. 2/ 
One leading hypothesis involves viral “molecular mimics”—proteins from the virus that resemble the body’s own proteins. These mimics may trigger an immune response against the virus but unintentionally cause the immune system to target healthy tissues as well. 2/ 
Thus, vaccination with mRNA vaccines could lead to an enhanced immune response to future encounters with pathogens which are not specifically targeted by the vaccine. 2/ 
A group of researchers used special MRI techniques to assess perivascular spaces in the brain of 14 individuals with LongCOVID compared to 10 healthy controls. 2/ 
As demonstrated in animal studies, the vaccine removed sugar molecules from an area of a coronavirus spike protein that rarely mutates and created effective and plentiful antibodies to inactivate the virus. 2/ 
During the COVID-19 pandemic, school closures and lockdowns kept children indoors at unprecedented levels. Learning, play, and communication shifted almost entirely to digital screens. 2/
New research shows that tea, not coffee, may affect early brain development. Despite its higher caffeine concentration, coffee did not boost cognition, showing that polyphenols and catechins in tea may contribute to brain development. 2/ 
This new computational modeling of avian influenza variants' immunoprotein interactions reveals the H5N1 influenza virus is evolving to escape immunological defenses raised by previous infection or vaccination in mammals. 2/ 
Peroxisomes are small, membrane-bound structures within cells that play a crucial role in synthesizing and breaking down fat. 2/ 
They establish a connection between SARS-CoV-2 infection and COVID-19 sequelae in children, in which impaired T cell cytotoxicity triggered by TGFβ overproduction leads to EBV reactivation and subsequent hyperinflammation. 2/ 
Many people who died during the pandemic would likely have lived longer if the pandemic had not happened.More than half of the total years of life lost would have been lived without disability & independently if the pandemic had been avoided, even among people aged over 80. 2/
A smartphone's glow is often the first and last thing we see as we wake up in the morning and go to sleep at the end of the day. It is increasingly becoming an extension of our body that we struggle to part with. 2/ 
Researchers analyzed complement activation in NR-COVID-19 lungs and its association with aberrant host autophagic response. It is the first study to comprehensively show the local presence of the components of the three pathways and regulators of complement activation 2/ 
Researchers have genetically engineered bacteria and nutritional yeast to carry an enzyme that breaks down amoxicillin in the gut without affecting the antibiotic’s ability to fight infection elsewhere in the body. 2/ 
Children and teens with #LongCOVID have significant lung abnormalities detected with an advanced form of MRI, called free-breathing phase-resolved functional lung (PREFUL) MRI. 2/ 
A review of 180 studies suggests that LongCOVID symptoms like memory problems, poor concentration, & brain fog may be driven by self-sustaining feedback loops involving vascular dysfunction, neuroinflammation & gut-brain axis disruption 2/
A NEW study identified oral associated #LonhCovid primarily manifested as periodontal (gum) disease (COVID +ve: 73.1±18.9% vs COVID -ve: 33.1±14.3%) 
The study shows that initial infection with SARS-CoV-2 triggers production of the antiviral protein IFN-γ, which is a normal reaction from the immune system. 2/ 
Down syndrome is caused by the presence of a third copy of the 21st chromosome. The condition occurs in approximately 1 in 700 live births and is relatively easy to diagnose at early stages of development. However, there are no treatments. 2/ 