Pediatrician, ‘rational’ vaccine thinker, Editor Covid Vaccines, TB on Vaccines & many others, Past-Convener IAP COI, Member-WHO-VSN (https://t.co/eOvazlWULO)
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A smartphone's glow is often the first and last thing we see as we wake up in the morning and go to sleep at the end of the day. It is increasingly becoming an extension of our body that we struggle to part with. 2/ 
Researchers analyzed complement activation in NR-COVID-19 lungs and its association with aberrant host autophagic response. It is the first study to comprehensively show the local presence of the components of the three pathways and regulators of complement activation 2/ 
Researchers have genetically engineered bacteria and nutritional yeast to carry an enzyme that breaks down amoxicillin in the gut without affecting the antibiotic’s ability to fight infection elsewhere in the body. 2/ 
Children and teens with #LongCOVID have significant lung abnormalities detected with an advanced form of MRI, called free-breathing phase-resolved functional lung (PREFUL) MRI. 2/ 
A review of 180 studies suggests that LongCOVID symptoms like memory problems, poor concentration, & brain fog may be driven by self-sustaining feedback loops involving vascular dysfunction, neuroinflammation & gut-brain axis disruption 2/
A NEW study identified oral associated #LonhCovid primarily manifested as periodontal (gum) disease (COVID +ve: 73.1±18.9% vs COVID -ve: 33.1±14.3%) 
The study shows that initial infection with SARS-CoV-2 triggers production of the antiviral protein IFN-γ, which is a normal reaction from the immune system. 2/ 
Down syndrome is caused by the presence of a third copy of the 21st chromosome. The condition occurs in approximately 1 in 700 live births and is relatively easy to diagnose at early stages of development. However, there are no treatments. 2/ 
Researchers analyzed plasma biomarkers of acetaminophen (APAP) exposure in a cohort of 307 African American mother-child pairs. Detection of APAP in second-trimester maternal blood samples correlated with increased odds of ADHD diagnosis in children by age 8–10. 2/
SARS-CoV-2 main protease (Mpro) inhibitor nirmatrelvir has broad-spectrum antiviral activity against SARS-CoV, MERS-CoV, SARS-CoV-2, and common human coronaviruses HCoV-OC43, 229E, NL63, and HKU1. 2/ 
While the vagus nerve has long been thought to facilitate communication between the gut microbiome—the community of microorganisms living in the intestines—and the brain, direct evidence for this process has been limited. 2/ 
Using an advanced AI-driven approach called max-logistic intelligence, researchers identified genetic links between COVID-19 and two obscure infections—glanders and Sennetsu fever—potentially rewriting the narrative of how the virus emerged. 2/ 
Researchers focused on using specific MRI machine to study the brain in these participants to determine similarities in particular areas of the brain, such as the hippocampus, which plays a critical role in controlling memory and cognition 2/ 
The GWAS have identified only four loci potentially associated with the LongCovid, although these results did not statistically replicate between studies. 2/ 
It’s a subject that few prefer to talk publicly, yet in recent months, it has grown impossible to ignore. Across Karnataka, rising accounts tell of families who have lost loved ones to sudden, unexplained heart attacks, cardiac arrests & neurological issues 2/ 
One analysis of 8 countries by Economist media group suggested longCOVID could have cut their GDP by between 0.5% & 2.3% last year.
Brain cancer presents a unique set of challenges for researchers—by the time a person experiences symptoms, the tumors are often so complex that the fundamental mechanisms driving the tumor growth are no longer easy to identify. 2/ 
In addition, the treatment may not completely clear the virus, leaving behind infectious particles that invade the target cells. 2/
This research is revealing exciting new and unexpected facets of oxygen biology, but translating these findings to patients poses major challenges, because hypoxia can be dangerous. 2/ 
A particular protein called the placenta-associated protein 8 (PLAC8) expression was found in people who died following SARS-CoV-2 infection. Researchers show this protein is required for SARS-CoV-2 pancreatic infection and viral replication. 2/ 
🔥 Now, researchers have found a way to circumvent toxicities of systemic immunosuppression. They have engineered synthetic suppressor T cells that execute locally targeted immunoprotective programs. 2/ 