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Grateful to share our latest publication: We’ve previously shown age reversal is possible using gene therapy to turn on embryonic genes. Now we show it’s possible with chemical cocktails, a step towards affordable whole-body rejuvenation 1/17 aging-us.com/article/204896…
For over three years, the team @harvardmed has worked long hours searching for molecules that, in combination, reverse cellular aging & rejuvenate senescent human cells 👏 C1-6 are the cocktails below vs age 2/17 
To start, @JaeHyun_Yang @ChrisPetty314 and Thomas_dixon-McDougall who led the team developed high-throughput cell-based assays to distinguish young cells from old and senescent cells, including transcription-based aging clocks and a real-time nucleocytoplasmic… twitter.com/i/web/status/1…
The team identified six chemical cocktails (and more now) that restore NCC and genome-wide transcript profiles to youthful states and reverse transcriptomic age in less than a week 4/17
The team's findings build upon the discovery that genes called Yamanaka factors, can convert adult cells into induced pluripotent stem cells (iPSCs). This Nobel Prize-winning discovery raised the question of whether it might be possible to reverse cellular aging without causing… twitter.com/i/web/status/1…
We recognize the pioneering work of Alex Ocampo @ Juan Carlos Belmonte who, in 2016, showed that by switching Yamanaka factors on for short bursts made short-lived mice healthier and longer-lived. 6/17 cell.com/fulltext/S0092…
Our lab and collaborators including Bruce Ksander @MassEyeAndEar and @YuanchengLu have previously demonstrated that it is indeed possible to reverse cellular aging and restore youthful functions to tissues in vivo, without uncontrolled cell growth by virally-introducing a subset… twitter.com/i/web/status/1…
Studies on the optic nerve, brain tissue, kidney, and muscle have shown promising results, with improved vision and extended lifespan in mice and, recently, in April of this year, improved vision in monkeys 8/17 fiercebiotech.com/research/life-…
Preparations for human clinical trials of our first age reversal gene therapy are ongoing @lifebiosciences 9/17
There’s a race between many groups to show chemicals can rejuvenate cells like gene therapy can. I acknowledge these dedicated groups’ work, too, and look forward to even more exciting advancements in the coming years 🚀 10/17 @OcampoLab @gladyshev_lab @RetroBio_ @rejuvenatebio… twitter.com/i/web/status/1…
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