Professor, Scientist. Mission: Extend healthy life for all. Views & analyses are my own.
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CAR T-cell therapy, short for Chimeric Antigen Receptor T-cell therapy, is a type of treatment in which a patient’s immune T cells are changed in the laboratory so they will attack cancer cells or, in this case, senescent cells that cause aging
The “ITOA” states that a cause of aging is a loss of epigenetic information that disrupts the ability of cells to read the right genes, causing them to lose their identity and malfunction… 
Here’s the primary paper: 
1. From 1994-2005, the budding-yeast “silent information regulator #2” or “SIR2” gene was shown to extend lifespan & mediate lifespan extension due to hormetic biostressors e.g. heat, low aminos & calorie restriction…
Here a link to the paper…cell.com/cell-metabolis…
More and more scientists suspect that high iron levels probably cause normal cells to age faster and ultimately become senescent zombie cells 🧟♀️. We know for sure that a common feature of senescent cells is their high iron content 
Articles: 
Long-term drinking also induces changes in neurotransmitter systems that ultimately lead to the development of craving and alcohol-seeking behavior ncbi.nlm.nih.gov/pmc/articles/P… 
This is a brief by interesting study of the effects of palmitic acid (a saturated long chain fatty acid) on human HepG2 liver cells. Have been on a rev - metformin combo for >8 years.. 
I'm reminded how quickly discoveries came in the late 1990s and early 2000s, figuring out why yeast age and how to control yeast aging. The pace is picking up again, now in mice and monkeys
Newbies to the field argued that aging is not adaptive (helpful) for most species, so it cannot be a program... 
In this 2022 study, resveratrol taken for 6 months @ 500 mg/day) improved inflammation, renal function, blood glucose, inflammation, insulin resistance, and nutrient sensing systems in the elderly patients with type 2 diabetes 2/9. journals.lww.com/md-journal/Ful…
Leverages work I did with Lenny Guarente and team in the 1990's showing that epigenetic information loss (triggered by DNA instability) is a cause of aging... 
Congratulations to the teams @harvardmed @MassEyeAndEar and @lifebiosciences, the company I cofounded in 2017 to use longevity science to combat age-related diseases. Couldn’t be prouder! 2/ 
In a pooled analysis, these drugs, known as statins were associated with a decreased risk of dementia. The black bars are to the left of the center line for most clinical trials, which indicates protection from dementia. 2/3 
Calorie restriction diet limited daily total energy intake to 500 - 800 kcal. 5:2 diet was to eat healthily 5 d/w and skip meals 2 d/w. The HPD increased protein to 20 - 30% of the daily total energy or 1.5 to 2.0 g/kg bw. Exercise at least 3 x/week for >150 min was recommended