Professor @Harvard researching why we age & how to reverse it. Author & host of Lifespan. Mission: Extend healthy life for all. Views are entirely his own 🙏✌️
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In 2008, we showed movement of the NAD-dependent enzyme SIRT1 away from regulated genes to DNA breaks (which happen every day in every cell) is a key process in the loss of epigenetic information that we have proposed leads to aging and diseases 
Background: DNA methylation (DNAme) is a chemical modification of DNA on the "Cs" in DNA, which changes over time, the rate of which depends on how healthy you live over the course of your life... ⏰ 
Various mitochondrial stressors, such as pathogen infection and metabolic deficiencies, trigger the release of mtDNA into the cytosol and an inflammatory response, but why? 
L-theanine is known to reduce inflammation, stress and anxiety, among other effects. It is primarily found in tea leaves, especially green & black. Also in supplements. Common doses are 100 - 400 mg/d 
1. Labeling aging a disease could fuel ageism. Employers already assume older adults are less capable. The “disease” label may reinforce stereotypes and discrimination
Link to paper by Dr. Adiv Johnson link.springer.com/article/10.100…
This news is strong evidence that the original vision to develop therapies that reversal of aging to prevent and cure diseases of aging and injuries isn’t just a fanciful idea
The DunedinPACE aging measure was designed to assess the pace of aging by using 20 years of longitudinal measurements of 19 different biomarkers
A decline in hepatic NAD+ levels due to ethanol exposure is recognized as a key contributor to alcoholic liver injury
Over 180 mushroom species contain psilocybin, including Psilocybe cubensis, Psilocybe semilanceata (Liberty caps), and others 
By 2100, without improving healthspan or reversing fertility decline, the U.S. could lose over 50% of its workforce-driven GDP. Globally, the drop could exceed 40%. The future of economic stability depend as much on health as it does on innovation
Positive results were announced from a Phase 2a (efficacy) of a molecule called PP405 for the treatment of hair loss, Pelage Pharmaceuticals announced a few days ago. 
Here's our 2023 paper: 
In 14 centenarians followed until death, only SD of normal-to-normal interval (SDNN) showed significant correlation (ρ = 0.536; p = 0.048) with survival prognosis 
1. Obesity & metabolic disorders because processed foods are high in sugar, salt, & unhealthy fats.
Dopamine addiction related to social media occurs when users become reliant on the instant gratification and pleasure derived from likes, shares, and notifications, which trigger dopamine release in the brain
Frailty assessments of older people are commonly used in both the clinic and research, yet there are no accepted frailty biomarkers, and very little is known about the underlying molecular mechanisms of frailty