Amazing! Placing mice in low air pressure every other day slows hair loss, weight gain, osteoporosis & extends median lifespan by 12%. Ascribed to the killing of senescent, zombie cells

Could exercise, high altitude, or a drug have similar benefits? Let’s dig in🧵 Firstly, hypobaric (low) pressure should not to be confused with hyper-baric oxygen therapy (HBOT), which is also studied by longevity researchers, though there may be overlapping hormetic mechanisms between the two @NaturePortfolio

New study indicates that a decrease in nerve cell cholesterol caused by cortisol, inflammation & low SIRT1 activity may be a cause of major depression.

So, do statins exacerbate depression?

And since SIRT1 is NAD⁺-dependent, could NAD⁺ boosters treat or prevent depression? …🧵 Around 5–5.7% of adults worldwide experience depressive disorders at any given time. >280 million people!

Cannabidiol (CBD) does amazing things. According to a new study it:

* Increases SIRT1 & autophagy ✅
* Decreases mTOR ✅
* Upregulates SOX2 & OCT4 ✅
* Preserves telomeres ✅
* Reduces inflammatory NF-kB ✅
* Slows stem cell aging ✅

🧵 CBD, or cannabidiol, is the second most prevalent active ingredient in marijuana, with no effects indicative of any abuse or dependence potential

Statistically, you should not exist:

– Life-friendly universe: 1/10⁶⁰
– Earth + moon: 1/10⁹
– Multicellular life: 1/10⁴
– Intelligence & civilization: 1/10⁹
– Your genome: 1/70 trillion

You’ve already won the lottery 10 times in a row. Ignore small people & enjoy! Equivalent odds: winning the Powerball jackpot 10 times in a row

DNA breaks from cosmic rays disrupt the epigenome and release virus-like retrotransposons. Not wild theory. Fact

X-rays and CT scans probably do too but no one talks about it

https://twitter.com/ruth_hook_/status/1973947996393124128

This study in 2008 was the first evidence for the information theory of aging in mammals - the idea that DNA breaks and other major stresses cause chromatin modifiers like SIRT1 to relocate, which disrupts the epigenome & changes the expression of genes in ways that cause aging

Some plant polyphenols (resveratrol, quercetin & berberine) turn out to be dual modulators of both SIRT1 & GSK3b - important pathways for neuroprotection & epigenetic age resets... 🧵 In 2008, we showed movement of the NAD-dependent enzyme SIRT1 away from regulated genes to DNA breaks (which happen every day in every cell) is a key process in the loss of epigenetic information that we have proposed leads to aging and diseases
cell.com/fulltext/S0092…

Can cheek swab DNA reveal meaningful signals about your health, diseases and biological age?🏃‍♂️🏃‍♀️🧵... Background: DNA methylation (DNAme) is a chemical modification of DNA on the "Cs" in DNA, which changes over time, the rate of which depends on how healthy you live over the course of your life... ⏰

Exciting new paper @nature that could explain why inflammation rises as we age and why healthy diets and exercise suppress inflammation 👏 🧵 Various mitochondrial stressors, such as pathogen infection and metabolic deficiencies, trigger the release of mtDNA into the cytosol and an inflammatory response, but why?

NEW STUDY: The amino acid L-theanine, first isolated from green tea in the 1940s, is used to improve mood and sleep 🍵 Study in mice finds L-theanine suppresses metastasis of prostate cancer, the second most common cause of death in men worldwide... 🧵 L-theanine is known to reduce inflammation, stress and anxiety, among other effects. It is primarily found in tea leaves, especially green & black. Also in supplements. Common doses are 100 - 400 mg/d

Should aging be called a “disease”? A new philosophy paper says NO

Here are 4 arguments it may do more harm than good... 🧵

What do you think? 1. Labeling aging a disease could fuel ageism. Employers already assume older adults are less capable. The “disease” label may reinforce stereotypes and discrimination

NEW PAPER: Great summary of drugs and supplements that extend lifespan in mice & the likelihood humans will see similar gains in the near future... 🧵 Link to paper by Dr. Adiv Johnson link.springer.com/article/10.100…

NEWS: @lifebiosciences reports new drug candidate ER-300 improves liver health, while ER-100 restores healthy DNA methylation patterns in the monkey eye, with clear functional improvements. Human trials are on track for January. It’s happening...
🧵 tinyurl.com/4dysm7bv This news is strong evidence that the original vision to develop therapies that reversal of aging to prevent and cure diseases of aging and injuries isn’t just a fanciful idea
nature.com/articles/s4358…

A new study of 3720 people finds that low quality diets (e.g. refined grains, sodium, solid fats, added sugar & alcohol) associate with a faster pace of aging than healthy diets (e.g. whole fruits, greens, beans, dairy & whole grains) 🧵... The DunedinPACE aging measure was designed to assess the pace of aging by using 20 years of longitudinal measurements of 19 different biomarkers

NEW STUDY: NMN protects against alcohol-induced damage to the liver 🍻 A decline in hepatic NAD+ levels due to ethanol exposure is recognized as a key contributor to alcoholic liver injury

Still struck by the dramatic effects of psilocybin on mouse health & lifespan 🍄‍🟫

Here’s some info about this molecule & where people obtain it: 🧵… Over 180 mushroom species contain psilocybin, including Psilocybe cubensis, Psilocybe semilanceata (Liberty caps), and others

The decreasing ratio of working to sick people is a threat to civilization. As more people live longer, sicker, and fewer are born, the ratio will reach a catastrophic 1:1 by 2080!

There is a solution 🧵 By 2100, without improving healthspan or reversing fertility decline, the U.S. could lose over 50% of its workforce-driven GDP. Globally, the drop could exceed 40%. The future of economic stability depend as much on health as it does on innovation

Recent news claimed scientists at UCLA had solved hair loss. Is this true?

Let's dive in 🧵 Positive results were announced from a Phase 2a (efficacy) of a molecule called PP405 for the treatment of hair loss, Pelage Pharmaceuticals announced a few days ago.

So what were the results and what is PP405? businesswire.com/news/home/2025…

NEW STUDY: Ocampo Lab publishes reprogramming cocktails that reduce DNA damage & extend lifespan of worms up to 42%.

The race is on to test them in humans 🚀 Here's our 2023 paper:
aging-us.com/article/204896

NEW STUDY: Only 14 centenarians in this study but higher heart rate variability (SDNN) was associated with longer life.

How do you know your SDNN? 🧵 In 14 centenarians followed until death, only SD of normal-to-normal interval (SDNN) showed significant correlation (ρ = 0.536; p = 0.048) with survival prognosis

"We aim to understand & reverse the underlying mechanisms of aging to treat a range of diseases & injuries...The loss of funding halts ongoing experiments that cannot simply be restarted," geneticist David Sinclair told @BBCNews 🧵
bbc.com/news/articles/… "The administration's excuse that these policies somehow address antisemitism are so absurd," said Jacob Miller, a student and former head of Harvard Hillel, the Jewish social hub on campus

NEW STUDY: 1 in 5 US kids is nutrient deficient. Malnutrition is associated with epigenetic age acceleration, up to 4.19 yrs. Therefore, it's key for you & your family to eat fresh food or take certain vitamins 🥦🫐🫛🥑

Here are 5 effects of a deficiency & how to prevent it: 1. Obesity & metabolic disorders because processed foods are high in sugar, salt, & unhealthy fats.

2. Poor gut health - a lack of fiber & plant diversity impairs the microbiome...