NEW STUDY: Intermittent fasting produces anti-depressant effects by modulating the dopamine receptor in mice. Could depression & social media addiction be cured by fasting? 🧵 Dopamine addiction related to social media occurs when users become reliant on the instant gratification and pleasure derived from likes, shares, and notifications, which trigger dopamine release in the brain

Proud to share a free link to our latest paper — a mouse metabolomics frailty prediction clock ⏰

Collab with @Alice_E_Kane 👏 @Nature_NPJ Frailty assessments of older people are commonly used in both the clinic and research, yet there are no accepted frailty biomarkers, and very little is known about the underlying molecular mechanisms of frailty

Medical misinformation is dangerous. Fact is statins reduce cardiovascular risk by ~25% per 1 mmol/L LDL drop (Lancet, 2010) & don’t harm the brain, which makes its own cholesterol (JAMA Neuro, 2021).

Statins aren’t “harmless” but social media myths are far more harmful 🧵

https://twitter.com/chrisboettcher9/status/1924805076322746439

Data from 170,000 people indicates each 1 mmol/L reduction in LDL cholesterol with statin therapy reduces the risk of major vascular events by approximately 25%, regardless of baseline cholesterol levels thelancet.com/article/S0140-…

NEW STUDY: 8 patients taking 1000 mg/d nicotinamide riboside (NR) for a month saw improvements in brain vasculature & cognition.

What’s the evidence NAD boosters improve blood flow and cognition in humans? 🧠🧵 In 2018-19, we and Zoltan Ungvari’s lab showed that mice treated with an NAD booster (NMN) had better blood flow in muscle & brain, with greater endurance & cognition

How healthy are your gums? New study finds a significant genetic overlap between gene variants for gum disease and age acceleration

How might gums affect aging & how do I maintain excellent oral health? 🦷🧵 Periodontitis is a chronic inflammatory disease caused by the accumulation of bacterial biofilms (plaque) on teeth, resulting in inflammation, swelling, bleeding & regression of gums

NEW STUDY: It's dogma that fasting is good for you because it increases autophagy, the recycling of cell parts. But in the largest study ever, 6 months of time-restricted eating (TRE) or calorie restriction (CR) did not increase autophagy

Huh? Is fasting still worth it? ... 🧵 121 humans with obesity who were randomized to standard care (SC), calorie restriction (CR) or intermittent fasting plus time-restricted eating (iTRE), the largest study to measure human autophagy in response to a nutritional intervention

NEW STUDY: Intermittent fasting improves fertility -not by improving sperm - but by making mice hornier

Does this happen in people?
@Cell_Metabolism In humans, aging is well-known to promote HSDD*, a syndrome characterized by low sexual desire associated with psychological stress

*(Hypoactive sexual desire disorder)

Longevity is built one good habit at a time. Here are 5 habits to start today: 🧵 1. Eat within a shorter time window (2 to 5 years extra) 🍽️ I try to eat one meal or a late lunch and early dinner. A 4-8 hour time window can activate longevity genes and increase insulin sensitivity

NEW PAPER @biorxivpreprint Brain aging is associated with a "shift toward stress-responsive programs & a progressive loss of cell identity with aging" consistent with The Information Theory of Aging
tinyurl.com/2zc85kba "Epigenetic aging is also reversible process, as expression of pluripotency factors (OSK(M)), activation of SIRT6, and modulation of other histone modifying enzymes 1have been shown to mitigate certain aging phenotypes."

The polyphenol fisetin found in strawberries clears senescent cells in diabetic mice to prevent aortic aging. Combined with metformin it shows even better effects 🍓🧵 Fisetin (Aladdin, CAS: 528-48-3, Powder Purity: ≥ 95%) was prepared in 60% Phosal 50 PG, 30% PEG400, and 10% ethanol. Fisetin or vehicle was administered in mice by oral gavage

NEW PAPER: DNA methylation entropy is proportional to chronological age, supporting the Information Theory of Aging, the concept that our bodies are biological computers running on software that becomes corrupted over time but can be reinstalled...🧵 aging-us.com/article/206220… Somatic cells in the human body share the same genome, yet they must differentiate into diverse cell types to perform the vast array of tasks

12 lessons students learn in the Sinclair Lab:

Lesson 1. Write the way you speak Lesson 2: Avoid unnecessary jargon when possible. It only makes you seem less intelligent

Here’s a list of all major sources of DNA damage in our daily lives & how to avoid them.. 🧵

https://twitter.com/thebcmessenger/status/1902840877543985618

Of all the various types of DNA damage, double stranded DNA breaks (DSBs) are believed to be the most potent cause of aging. Here are 2 mice, one that’s experienced ~3x more DSBs than its sibling

NEW STUDY: Food and drinks that associate with healthy aging, better memory & a longer, disease-free life & those that don’t. Surprising results… 🍷🍟 🧵 How to read the figures in this new paper: green means heathy, red means unhealthy. Column 1 is healthy aging, 2 is cognitive function and so on…

Polyphenols aren't just antioxidants. They signal to the body - defend and heal. New evidence indicates that polyphenols might prevent cancer by modulating small RNAs... a thread 🧵 In the 1990's, antioxidants were all the rage. Today, we know so much more, though the food and beverage industry still promotes antioxidants as though they were the most important thing...

NEW STUDY: SIRT5, the neglected mitochondrial Sirtuin, which depends on NAD, is shown to slow muscle aging 🧵 @NatMetabolism When SIRT5 was delivered to skeletal muscle it enhanced physical performance and alleviated age-related muscle dysfunction

NEW STUDY: 50-80% of us will experience back pain in our lives. OSK is shown to alleviate cellular senescence 🧟 & back pain 🐀 suggesting epigenetic reprogramming might address this major economic burden & #1 cause of human disability… 🧵 OSK stands for Oct4, Sox2 and Klf4, three genes that are part of a set that Shinya Yamanaka showed can make adult cells into pluripotent stem cells. The gene products are transcription factors that control how genes are turned on and off (during embryogenesis)

GLP1 receptor agonists are looking like longevity drugs. A new study reports that drug-induced improvements in bone mass are mediated by the NAD-dependent SIRT1 enzyme.
If so, could NAD boosters work with GLP-1 drugs? Some thoughts...🧵 This new study is consistent with studies showing NMN, an NAD booster & SIRT1 activator, improves bone mass in mice

Imagine being able to predict or detect diseases with a cheek swab? NEW STUDY finds a cheek clock associates with 33 conditions:

1. Various cancers
2. Aging
3. Prediabetes
4. Depression
5. Lung fibrosis
6. Chemicals
7. Fatty liver

How is it possible? 🧵
tinyurl.com/4db5r2tc I am proud to have worked with the dream team that developed this next-gen epigenetic clock using buccal cheek swab data, one of the largest clock studies...

10 quotes from Thomas Kuhn that changed my life and have never been more relevant:

1. The competition between paradigms is not the sort of battle that can be resolved by proofs

(Scientists, read that again) 2. When paradigms change, the world itself changes with them

The mTOR inhibitor Sapanisertib is a putative longevity molecule that makes human skin cells & prematurely old fish healthier

Combined with metformin (a putative longevity drug), 79% of human patients with advanced or metastatic solid tumors achieved disease control. Promising results.

Could S+M be a longevity combo and who owns it? 🧵
tinyurl.com/bdbkx2re Metformin’s metabolic benefits might counterbalance Sapanisertib’s potential side effects, like insulin resistance, seen in some patients taking the mTOR inhibitor rapamycin
frontiersin.org/journals/neuro…