Professor researching why we age & how to reverse it. Author of Lifespan. Mission: Extend healthy life for all. Views are his entirely his own 🙏✌️
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The 1st paper by Qu et al. shows lithocholic acid (LCA) alone can recapitulate the effects of calorie restriction (CR) in mice, including AMPK activation, muscle regeneration & increased grip strength and running capacity. LCA also increases health and lifespan in nematode worms and flies...
btw, there is no scientific reason for the "vs" in the figure above 😖
20% of couples struggle with infertility (50-60% are male issues). By 2100, 97% of countries will be unable to maintain their population
DNA methylation (DNAme) age reductions. Red asterisks represent statistical significance 
Luteolin, a polyphenols, is found in small quantities in many plants and plant products we eat, such as mint, tomatoes, celery, broccoli, artichoke, oranges, parsley, thyme, rosemary and even honey… 
The Belmonte lab has been a leader in the reprogramming field since they showed OSKM could improve health and extend the lifespan of a prematurely aging LMNA mouse strain. Here they reprogram senescent cells of these and normal mice and show it safely extends lifespan 🐁 Amazing…
A custom DNA methylation lock was created to measure the biological aging of CALERIE trial subjects
Dr. Hayflick discovered the Hayflick limit: that normal human cells have a finite number of divisions before they stop. This challenged the then-prevailing belief that cells could divide indefinitely 
In the 1940s, Barbara McClintock discovered that retrotransposons, or “jumping genes,” cause color variety in corn by moving within the genome and disrupting pigment genes, earning her the Nobel Prize in 1983 🌽🥇 
IL-11 is a cytokine, a type of signaling protein secreted by the immune system that plays various roles in inflammation, immune responses, and the formation of blood cells 
The study included data from 93 dog breeds including the Great Dane (6.3 years) and Toy Poodle (14.6 years)... 
I3C triggers DNA repair, cell-cycle arrest, apoptosis, disruption of cell migration, and modulates hormone receptor signaling 
Young blood has been shown to enhance cognitive function, stem cell function, and tissue repair, as well as increase the lifespan of rodents. Check out the amazing work by Irina and Michael Conboy's labs (pictured below)
CAR T-cell therapy, short for Chimeric Antigen Receptor T-cell therapy, is a type of treatment in which a patient’s immune T cells are changed in the laboratory so they will attack cancer cells or, in this case, senescent cells that cause aging
The “ITOA” states that a cause of aging is a loss of epigenetic information that disrupts the ability of cells to read the right genes, causing them to lose their identity and malfunction… 
Here’s the primary paper: 
1. From 1994-2005, the budding-yeast “silent information regulator #2” or “SIR2” gene was shown to extend lifespan & mediate lifespan extension due to hormetic biostressors e.g. heat, low aminos & calorie restriction…
Here a link to the paper…cell.com/cell-metabolis…
More and more scientists suspect that high iron levels probably cause normal cells to age faster and ultimately become senescent zombie cells 🧟♀️. We know for sure that a common feature of senescent cells is their high iron content 