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Hideki Kakeya, Dr.Eng. Profile picture
@hkakeya
Aug 4 • 3 tweets • 1 min read Twitter logo Read on Twitter
BREAKING: Our preprint titled "Repeated emergence of probabilistically and chronologically anomalous mutations in SARS-CoV-2 during the COVID-19 pandemic" has just been published. The data suggest possibility of repeated lab leaks during the pandemic.
zenodo.org/record/8216232
The preprint was first posted to bioRxiv, but they rejected it, saying "bioRxiv is intended for complete research papers with new data/analysis and your submission does not fall into that article type." Please read the paper to see whether bioRxiv is fair in its decision.
This is the 2nd time bioRxiv rejects our preprint. In the 1st case, the rejected paper was peer-reviewed and accepted to a journal shown below. We plan to submit the above preprint to a journal under no pressure from Western virologists to see the result.
jstage.jst.go.jp/article/ipsjtb…

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More from @hkakeya

Hideki Kakeya, Dr.Eng. Profile picture
Jan 20
村木厚子氏が話題になっている。昔「インターネットマガジン近未来」というエッセイをWeb上で公開していたが、2010年12月27日に次のようなことを書いていたので紹介する。

厚生労働省の上村勉元係長の郵便不正事件について、共謀の疑いで起訴された村木厚子元局長の無罪が確定した。1/n
検察の証拠でっち上げにより罪を疑われた村木氏には同情の意見が多い。もちろん、共謀の事実がないのにそれを疑われたこと自体については、私も強く同情する。しかし、事件当時上村氏の直属の上司であった村木氏の職務上の監督責任については、共謀の事実がなくともその責任は重く問われて 2/n
しかるべきである。にもかかわらず、村木氏が冤罪の被害者であるという側面ばかりが取り上げられ、監督責任を果たせなかったことについて何ら責任追及がなされていないことについては、あまりに不自然であるとしか言いようがない。3/n
Read 5 tweets
Hideki Kakeya, Dr.Eng. Profile picture
Sep 16, 2022
日本ではいまだにファウチを信奉する医師や専門家（ウイルス学者）を信じろというジャーナリストが散見される。彼らが全く信用に値しないことはこの記事から明らか。全てソース付きの良記事。サマリーの部分を翻訳する🧵
usrtk.org/biohazards/tim…
2020年
1/27 Fauciは自身が武漢ウイルス研究所(WIV)に研究費を提供していたことを知る
1/29 AndersenがWIVのコロナウイルス機能獲得研究の論文を発見
1/31 FauciとAndersenが私的に話す。後のNature Medicineの論文の著者3人を含む4人のウイルス学者は新型コロナは自然の進化で発生しえないとの見解
2/1 Fauciがウイルス学者とNIHの間で秘密のビデオ会議を主催。同時にFauciはNIAIDがどのプロジェクトで研究資金提供をしていたかさらに調査
2/2 ウイルス学者たちが意見交換。何人かは研究所起源に傾く。GarryはRaTG13と比較してSARS-CoV-2が自然発生することは理解不能と語る
Read 6 tweets
Hideki Kakeya, Dr.Eng. Profile picture
Sep 15, 2022
In late July, I had a talk with a famous Japanese virologist in an internet program. He said he had found the sequence of SARS-CoV-2 suspicious, but he kept silent because it would make research using BSL-4 labs in Japan all the more difficult.
nicovideo.jp/watch/so408449…
Here's a summary of our talk in English.
MC: Another surge of coronavirus infection, emergence of monkey pox. It seems endless. How will things turn out?
M(Miyazawa): When the pandemic broke out, I found the virus suspicious, but believed it had originated from nature...
But Omicron was more suspicious, and now the monkeypox. The reaction to monkeypox by WHO and CDC is apparently weird, which makes me think of a possibility of plandemic. Horrific.
K(Kakeya): Omicron has 30 or more mutations in spike...
Read 12 tweets
Hideki Kakeya, Dr.Eng. Profile picture
Sep 13, 2022
論文を読まれていないようですね。dN/dS=1は先行研究のSARS2のdN/dS比を調べた上での仮定です。なお、査読を通った論文ではdN/dS>1の場合も計算しています。また、他の変異株の選択圧の傾向をもとに計算した解析でも近い結果が出ています（近々プレプリントにまとめます）。
選択圧が強い状態でもdN/dSが1前後になる理由は、N変異をランダムに起こすと生存に不利になることが殆んどだから。だからdN/dSは通常1よりかなり小さい。選択圧が強いと1に近づく、あるいは1を超えることもあるが、大きくは超えない。遺伝的アルゴリズムを走らせた経験があると理解しやすいだろう。
選択圧が強く変異の試行錯誤が多い場合、選択に影響するスパイクにN変異が集中するのは自然だが、同時に全体的にS変異が増えないとおかしい。でなければ、自然界が事前に正解を知っていることになる。私はラマルク説をとらない。
Read 5 tweets
Hideki Kakeya, Dr.Eng. Profile picture
Sep 12, 2022
"It is true that statistical bias alone, even if it is extreme, cannot be a definitive proof of lab-leak. Direct proofs of genetic modification in a laboratory are needed for final judgement."
zenodo.org/record/7066413
"The problem is lack of transparency in the current culture of life science. The Wuhan Institute of Virology took its virus database offline in September 2019 and has never shared the data since. It also has never accepted full inspection of its facilities by a third party."
"In case of forensic investigation, prosecutors are allowed to raid the suspect when an investigation warrant is issued by the judiciary. A compulsory investigation is admitted when circumstantial evidences strongly support the prosecutor’s claim."
Read 4 tweets
Hideki Kakeya, Dr.Eng. Profile picture
Sep 5, 2022
Our paper below, which shows that the Omicron variant is highly likely a product of artificial genetic modification, is accepted to a journal after two rounds of peer reviews. The fact that the reviewers agree with our conclusion means a lot.
zenodo.org/record/6904363
I've just received notification of acceptance and the reviewed version is under editorial process. Though the accepted version includes some major revisions, the gist remains the same. I keep the journal name secret at this moment. Zoonosis proponents may harass the publisher.
The paper will be published in a month or two in a journal of an academic society with around 20,000 members, so it's not a predatory journal. I'm not like Fauci, who hides everything unfavorable. We can't make public the reviewed version now, for we've transferred the copyright.
Read 5 tweets

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