Thread by @MaxGulhaneMD

The clinical focus on LDL and total cholesterol for prevention of aethrosclerotic cardiovascular disease (ASCVD) is to the exclusion of underlying root causes, which are readily modifiable by easily implemented lifestyle interventions - short thread

Visceral fat/hyperinsulinemia/hyperglycemia - normalize circadian rhythm, avoid carbs, sugar, seed oils

Glycocalyx injury/endothelial repair - avoid high blood pressure, smoking, MAX nitric oxide (sun, exercise)

Oxidation of LDL - avoid seed oils

Trig:HDL - diet as above

Medications are appropriate in certain settings for certain patients. It is notable that statin therapy does not alter the oxidation of LDL, improve HDL, reduce trigylcerides or reduce hyperinsulinaemia

Overview of the thrombogenic hypothesis of ASCVD by @malcolmken

journals.lww.com/co-endocrinolo…

Lack of evidence for statin therapy for those with high LDL-c on low carb diet by @DrPaulMason, @LDLSkeptic, @BenBikmanPhD

journals.lww.com/co-endocrinolo…

As I mentioned in my recent presentation at the Regnerate health summit, ectopic fat is really the elephant in the room - its deposition represents the fundamental pro-inflammatory, pro-thrombotic effect that initiates endothelial injury and perpetuates it

Pericardial and visceral fat can be directly visualized under MRI. Lifestyle interventions that eliminate pericardial, visceral and other forms of ectopic fat will address those pro-inflammtory, pro-thrombotic drives of disease

mdpi.com/1422-0067/20/2…

Listen to the Regenerative Health Podcast where we discuss these questions and more

podcasts.apple.com/podcast/id1661…