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Max Gulhane MD Profile picture
Max Gulhane MD
@MaxGulhaneMD
Health optimization Regenerative farming #Nguni cow advocate
Dec 25, 2024 • 4 tweets • 2 min read
What if our light environment was the biggest missing piece of infertility treatment?

'Sleep disorders are significantly associated with infertility. Poor sleep quality, extreme sleep durations, and certain sleep chronotypes are associated with poorer fertility treatment outcomes, such as a reduced number of retrieved oocytes, decreased embryo quality, and lower fertilization rates.'Image Once again human disease is linked to artificial light exposure:

'The circadian rhythms of the Clock gene system, melatonin and hormone dysregulation, oxidative stress and immune response are considered to be potential mechanisms explaining how sleep disturbance impairs reproductive function, remain to be fully elucidated, and therefore, require further investigation.'

pmc.ncbi.nlm.nih.gov/articles/PMC11…Image
Dec 22, 2024 • 8 tweets • 3 min read
Pro-opiomelanocortin (POMC) physiology explains why environmental signals of LIGHT & TEMPERATURE are key to metabolic health and weight loss

Here’s a brief overview🧵 Image Leptin resistance = weight loss resistance

Disordered circadian light signals and insulation from ambient temperature cues is a shortcut to leptin resistance Image
Dec 29, 2023 • 4 tweets • 2 min read
The function of all your metabolic organs - liver, pancreas, adipocyte, muscle, gut - contain circadian timing mechanisms

Leptin, circadian hormone, acts centrally to inform total body energy stores

Chaotic light signals = metabolic disease Image Food first mindset = only intrinsic food factors ie macronutrient composition relevant to developing metabolic dysfunction

Big picture mindset = external, environmental signals ( LIGHT, temperature & meal timing >> meal content in initiating & perpetuating metabolic disease Image
Aug 11, 2023 • 8 tweets • 2 min read
The clinical focus on LDL and total cholesterol for prevention of aethrosclerotic cardiovascular disease (ASCVD) is to the exclusion of underlying root causes, which are readily modifiable by easily implemented lifestyle interventions - short thread Image Visceral fat/hyperinsulinemia/hyperglycemia - normalize circadian rhythm, avoid carbs, sugar, seed oils

Glycocalyx injury/endothelial repair - avoid high blood pressure, smoking, MAX nitric oxide (sun, exercise)

Oxidation of LDL - avoid seed oils

Trig:HDL - diet as above