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Aug 22 25 tweets 4 min read Twitter logo Read on Twitter
"A Deadly Feast": Chapter 1: The Red Feast

Begins below.
Enjoy!

#OW2023 #SFN2023 #neurotwitter #AcademicTwitter #hormones #ghrelin #LEAP2

The scent of anticipation lingered in the air..... Image
The scent of anticipation lingered in the air as the administrative team of the Center for Hypothalamic Research meticulously arranged a grand celebratory meal. The occasion was one that would forever be etched in the annals of scientific history.
The Center had overcome the dark shadows of the LEAP2 Conspiracy, unraveled the truth behind the ghastly murder that had haunted their labs, and emerged triumphant in the pursuit of justice.
Tonight was to be a feast, not only to honor the newfound freedom of Dr. Kevin Williams but also to mark the birth of a powerful alliance—the Ghrelin 5.
The elegant dining hall sparkled with an array of glistening silverware and crystal glassware. The long table was adorned with floral centerpieces, and candles cast a warm glow over the scene.
The air crackled with excitement as scientists and postdoctoral fellows from the laboratories of Dr. Alfonso Abizaid, Dr. Jamie Roitman, Dr. Mitch Roitman, and Dr. Jeffrey Zigman mingled, their conversations a harmonious blend of relief, curiosity, and pride.
Dr. Alfonso Abizaid, a renowned neuroscientist from Canada, surveyed the room with a mixture of satisfaction and caution. He had been a key player in unraveling the sinister plot that had ensnared Dr. Kevin Williams.
His piercing eyes hinted at the countless hours spent poring over data and connecting the dots. Tonight, he hoped to set aside the shadows that had haunted them and revel in the success they had achieved.
Dr. Jamie Roitman, an esteemed scientist hailing from Chicago, exchanged smiles and enthusiastic nods with her equally esteemed scientist husband Dr. Mitch Roitman. The couple had been an inseparable force in exposing the truth behind the LEAP2 Conspiracy.
Jamie's silvery white hair, furled brows, and infectious laughter brightened the room, while Mitch's sharp intellect and calm demeanor served as a steady anchor amidst the turmoil. They had weathered storms together and had come out stronger, united in their pursuit of justice.
Dr. Jeffrey Zigman, the host of the feast and the man whose laboratory had once been the backdrop for tragedy, stood at the head of the table. His tall and lanky frame spoke of a focused determination.
A world-renowned expert on the hormones ghrelin and LEAP2, Zigman's dedication to his research had been overshadowed by the murder that had taken place within his very own lab.
Tonight, he sought solace in the camaraderie of his fellow scientists, hoping that this feast would wash away the lingering stains of the past.
Dr. Kevin Williams, the formerly disgraced but now vindicated electrophysiologist and neuroscientist, also looked around the room. While in jail, he had missed scientific conference after scientific conference.
His access to the scientific literature had been restricted and he was kept in the dark about most new discoveries about the neurocircuitry controlling food intake, body weight and the metabolic responses to exercise.
His former lab had already been forcibly disbanded and thus none were present at this celebratory feast.
As the guests took their seats, a hushed anticipation settled over the room.
The murmurs of conversation ebbed and flowed like a distant tide, punctuated by the clinking of glasses and the soft clatter of cutlery. It was a moment of unity, of triumph over adversity, and the promise of a brighter future.
The air was thick with a symphony of aromatic delights, mingling together to create an irresistible fragrance that wafted through the room.
The tantalizing scent of freshly baked bread and naans and fried puris and parathas filled the air, accompanied by the savory aroma of roasted meats and herbs. It was a harmonious blend of flavors, promising an unforgettable culinary experience.
The sight was a feast for the eyes as well. Tables adorned with vibrant platters of colorful fruits and vegetables beckoned, their juicy ripeness and crispness shining under the warm glow of candlelight.
Glistening sauces and gravies cascaded over succulent dishes and curries, adding a rich and enticing sheen. Plates and platters overflowing with Coffee Crisp candy bars added a sense of Canadian whimsy to the scene.
The sounds of sizzling and crackling echoed from the kitchen, creating a symphony of culinary artistry. Laughter and chatter filled the room, intermingling with the clinking of glasses and the occasional gasp of delight as guests savored each exquisite bite.
It was a sensory extravaganza, a feast that celebrated not only the flavors but also the joy of coming together to share in the pleasure of delicious food.
Suddenly, without warning, the room plunged into utter darkness. Gasps and startled exclamations filled the air as panic rippled through the crowd. The celebratory atmosphere shattered, replaced by a primal fear that gripped everyone in its icy talons.
Screams pierced the darkness, their piercing echoes ricocheting off the walls. As the seconds stretched into an agonizing eternity, the assembled principal investigators held their breath, paralyzed by the unknown.....

stay tuned for the continuation of Chapter 1! Image

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More from @ZigmanLab

Aug 23
The 2nd half of Chapter 1 of A Deadly Feast (Book 3 of The #GhrelinMurders Trilogy) now continues......

(Get caught up on the 1st half of Chapter 1 here:
)

Suddenly, without warning, the room plunged into utter darkness.... threadreaderapp.com/thread/1693983…
Image
Gasps and startled exclamations filled the air as panic rippled through the crowd. The celebratory atmosphere shattered, replaced by a primal fear that gripped everyone in its icy talons.
Screams pierced the darkness, their piercing echoes ricocheting off the walls. As the seconds stretched into an agonizing eternity, the assembled principal investigators held their breath, paralyzed by the unknown.
Read 20 tweets
Jun 2
If ur enjoying "The Ghrelin Murders": A Hormone Murder-Mystery in 10 Chapters, check our @ZigmanLab @oceankripa latest paper on #ghrelin & #recurrenthypoglycemia @NIDDKgov frontiersin.org/articles/10.33… Find authors @oceankripa @deepapli1 at #ENDO2023 @TheEndoSociety
and Now Chapter 6 Image
Chapter 6: "Conflicting Desires".
Dr. Jeffrey Zigman was at a crossroads, torn between two seemingly irreconcilable paths. On one hand, his scientific career hung in the balance, with multiple grants demanding his attention. Without securing the necessary financial support,...
...his state-of-the-art laboratory would be forced to close its doors, bringing his research to a grinding halt. On the other hand, his unwavering determination to solve the murder-mystery consumed his thoughts, pushing him further into the depths of the chilling investigation.
Read 16 tweets
Jun 2
While the fictional boss is investigating a murder-mystery, @oceankripa is doing the real work with @SalilVarshney7 @deepapli1 & others investigating the potential role for #ghrelin in hypoglycemia unawareness associated with recurrent hypoglycemia. #T1DM doi.org/10.3389/fendo.… Image
Recurrent episodes of insulin-induced hypoglycemia in patients with diabetes can result in hypoglycemia-associated autonomic failure, characterized by a compromised response to hypoglycemia by counterregulatory hormones (counterregulatory response) and hypoglycemia unawareness.
This so-called HAAF is a leading cause of morbidity in diabetes and often hinders optimal regulation of blood glucose levels. Yet, the molecular pathways underlying HAAF remain incompletely described.
Read 11 tweets
Jun 1
Chapter 5: "Canadian Connections"
Dr. Jeffrey Zigman's investigation into the murder mystery had taken an unexpected turn, with intriguing clues pointing towards a Canadian connection.
@ObesitySociety @SSIBsociety @UTSWInternalMed @AbizaidAlfie @Jeff_Neuro @DanielJDrucker Image
Determined to uncover the truth, he reached out to his close scientific colleague, Dr. Alfonso Abizaid, a renowned researcher in Canada who shared Dr. Zigman's passion for ghrelin research. Image
With a mixture of anticipation and urgency, Dr. Zigman dialed Dr. Abizaid's number, eagerly waiting for his colleague's familiar voice on the other end of the line. As the call connected, he explained the perplexing situation and relayed the details surrounding the murder, ...
Read 18 tweets
May 31
And now, Chapter 4 of The Ghrelin Murders: Earlobes and Maple Secrets. #ghrelin #ghrelinmurders #hormonemurdermystery
Dr. Jeffrey Zigman found himself immersed in a world where ghrelin, neurocircuitry, and the mysteries of the mind intertwined with the perplexing murder case. Image
As he continued his investigation, he couldn't shake the significance of the handwritten clue mentioning "earlobes." It seemed like an unlikely detail, but Dr. Zigman knew that sometimes the most peculiar elements held the key to unraveling a mystery.
Deep in thought, he recalled a lesser-known area of scientific research—the connection between certain physical traits, such as earlobe shape, and underlying genetic factors. Earlobes could be classified into two main types: attached and unattached.
Read 17 tweets

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