Thread by @nootropicguy

10 potent tools to 10x your dopamine levels

THREAD 🧵

DISCLAIMER: This is not medical advice. I am not a doctor. Consult a doctor before using any supplement or drug. Do your own research on the risks of each supplement or drug prior to using.

Dopamine is the #1 key to success

It's essential for:

- motivation/willpower
- attention/focus

Strategically enhancing dopamine while simultaneously using it in a productive manner sets you up to win big

With that, let's dive right into it...

1) SAFFRON

FIrst up is Saffron

Everyone knows about Saffron as a culinary spice

But few understand it's cognitive-enhancing power

Here's how it works:

Saffron contains dopaminergic bioactives such as crocin that:

- Inhibit Dopamine Reuptake
- Inhibit Noradrenaline Reuptake
- Block Serotonin 5-HT2C Receptors

And according to a human study out of Iran, Saffron is as effective as Ritalin for treating ADHD

Let that sink in...

From my experience, extracts rich in crocin such as the ones below are much more stimulating

I've been taking 60mg daily as of late and haven't looked back

lddy.no/1eqcp

2) CATUABA BARK

When I tried Catuaba for the first time two years ago, I blown away by how potent it was

It was noticeably stimulating without the typical stimulant jitters

And when you look at the science behind it, it makes total sense

Catuaba:

- Increases dopamine release
- Inhibits dopamine reuptake
- Prevents dopamine breakdown (mild)


While Trichilia catigua is considered “true Catuaba..."

Erythroxylum catuaba is very similar and is just as potent in my experience

If not more potent...

3) BROMANTANE

Bromantane is my favorite compound on this entire list

Here's why:

Bromantane boosts dopamine levels...

But unlike something like Adderall, it does so without addiction, tolerance, or withdrawal

Read that again...

How?

1) Increases DA synthesis (TH/AAAD)
2) Increases DA sensitivity (BDNF/GDNF)

It has a noticeable acute effect that

a) builds with consistent use
b) synergizes with other dopaminergics

While it's safe overall IMO, it’s not a supplement nor is it an approved drug in the USA

4) CORDYCEPS

Cordyceps is infamously known as “Himalayan Viagra”

It reliably increases testosterone via bioactives that are analogous in structure to luteinizing hormone

Testosterone indirectly boosts dopamine via epigenetic mechanisms, but Cordyceps doesn't stop there...

Cordyceps is not only "Himalayan Viagra"

It's also "Herbal Bromantane"

It shares 2 key benefits with Bromantane:

1) Boosts dopamine synthesis by upregulating tyrosine hydroxylase

2) Enhances endurance & oxygen utilization

To be honest, Bromantane is much more potent tho

5) RHODIOLA ROSEA

Cordyceps isn’t the only dopamine-boosting adaptogen

As it turns out, Rhodiola Rosea also powerfully boosts dopamine, in more way than one

- Blocks DA breakdown (COMTi/MAOi)
- Enhances dopaminergic neurogenesis
- Increases BBB permeability to dopamine

This may surprise some of you who consider it a calming, anti-stress herb

But extracts that are rich in SALIDROSIDE (rather than rosavin) are much more stimulating in my experience

I've been using this for 8 months and it's been a game-changer

amazon.com/dp/B0751HBW2F?…

6) ISTRADEFYLLINE

Like Bromantane, this one is technically a pharmaceutical drug

It's used in Parkinson's Disease where dopamine levels are low due to neurodegeneration

It indirectly increases dopamine (D2 receptor) signaling via blocking the adenosine A2A receptor

Because A2A receptors form heteromeric complexes with dopamine D2 receptors....

Blocking A2A increases D2 signaling

This improves certain Parkinson's symptoms & may help depression

And unlike caffeine, it shouldn't induce cardiovascular side effects or dependence

7) VIGNATEX

Vignatex is an innovative combination of

a) mung bean
b) passionflower

These 2, especially mung bean, contain compounds that slow the breakdown of dopamine (via MAO inhibition)

While Passionflower also inhibits MAO, it mainly works to smooth out any potential jitters via enhancing GABAergic activity

To be honest, I personally wouldn't use Vignatex for nootropic purposes

But it may potentially be useful for lowering prolactin or Restless Leg Syndrome

8 + 9) SABROXY & POLYGALA

Sabroxy & Polygala are 2 of the heavy hitters on this list

And Notable Focus contains both

Sabroxy boosts dopamine via its key bioactive Oroxylin A, a potent dopamine reuptake inhibitor

Polygala works similarly via yuanzhi-1 & also inhibits MAO

Because I formulated Notable, I'm biased...

But I strongly believe this is one of the most potent dopamine-boosting supplements on the market

I recommend 2-4 capsules, or 1 capsule dumped & held under tongue

Very synergistic w/ caffeine

meetnotable.com

10) PHENYLPIRACETAM

Phenylpiracetam was everyone's favorite nootropic

Until it recently got banned by the FDA

It's also banned in sports by WADA

(Bromantane too)

That how you know it works 😉

Unlike other racetams, it supercharges dopamine by blocking dopamine reuptake

It also:

- Boosts neurogenesis via BDNF
- Boosts alpha- and beta-wave activity

Depending on ur location, you can buy from Cosmic Nootropic, but I haven't used theirs yet so YMMV

10% off w/ NOOTBRO

That's the thread

There are many others, including a novel one I am adding to Notable V2

I'll be detailing this one & even more powerful ones in my newsletter in the days to come

You won't want to miss this 👇

nootbro.substack.com

If you found this helpful, consider tossing me a RT on the original tweet

https://twitter.com/nootropicguy/status/1695556233548177480