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Petr Svoboda Profile picture
@SvobodaLab
Sep 8, 2023 • 11 tweets • 4 min read • Read on X
Scrolly
Neural crest cells are evolution's duct tape for fixing poor design issues. Really.
Cardiac septum.
Facial structures Image
Glia Image
Smooth muscle Image
Mesectoderm. Image
... can you come up with more examples of #neuralcrest #ducttape @JanStundl @Fabian_Lab ?
Melanocytes. Image
... more facial structures ... impressive divergence ...


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Musculoconnective tissue wall of the large arteries Image
Numerous components of the anterior segment of the eye


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More from @SvobodaLab

Petr Svoboda Profile picture
Oct 28, 2024
@TomatoFilipi @weblog20 1/n Kvalitni veda potrebuje:

napady
lidi
penize
cas

Administrativa by mela byt schopna starat o ty posledni dve veci, o druhou se starat ve spolupraci s vedci. Vedci by se meli postarat o tu prvni. Stat ma pro tu prvni akorat vykolikovat hriste. CR bude stezi mit dost $$.
@TomatoFilipi @weblog20 Kazdy z tech 4 faktoru je samostatny problem, jejichz spolecnym jmenovatelem je svebytna akademicka kultura, kde si administrativa usurpuje vetsi roli, nez by ji mela patrit, zatimco vedu ridi jako cargo cult. Paradoxne to casti akademicke obce vyhovuje a adaptuje se na to.
@TomatoFilipi @weblog20 Cas, nejcennejsi komodita, aby vedec mohl lip mezinarodne konkurovat, tu sel do pr*dele. V CR vznikl byrokraticky moloch, kteremu pojem casu unika. Cas vedcu byrokracii nezajima. A s kazdym dalsim zakonem, administrativnim opatrenim, ci grantem to uzirani casu narusta.
Read 10 tweets
Petr Svoboda Profile picture
Feb 21, 2023
This will be a growing thread with stochastic tips for PhD applications & interviews. Many of them were likely mentioned by others but I see them repeatedly popping up during interviews and some of the issues do a lot of damage to applicant's chances.
1) Regardless how simple your MSc. project was, it can be presented in a scientifically sound way and that's what an interviewer is looking for. A curious highly motivated candidate is able to formulate what was the goal and knows details, strengths and weaknesses of own work.
2) If you neglect your graphs, you have a problem. A graph is the basic way of presenting data. Imagine a candidate showing the key graph and it lacks labels, fonts are too small to read, samples have funny codes and it takes 5 min discussion to figure out what's on that graph.
Read 10 tweets
Petr Svoboda Profile picture
Feb 6, 2021
kde se berou mutac e a jak funguje evoluce viru - thread:

Virus je molekula nukleove kyseliny v obalu z bilkovin. Nukleova kyselina se vehem "zivota" viru zdvojuje 1-2-4-8-16-32-64-128 ... molekul. Pri kazdem JEDNOTLIVEM zdvojeni muze vzniknout chyba. 64->128 je 64 zdvojeni.
Pokud bude v populaci 100 000 nakazenych a kazdy kazdy bude nositelem 1000 000 viru, je to 100 000 000 000 viru, take to je 100 000 000 000 replikacnich procesu, a v kazdem muze dojit k chybe - virus je stroj na generovani mutaci. Proc s ho teda virus neznici samotne mutace?
1) ne kazda replikace je chybna, chybovost na jeden replikacni cyklus je velmi mala.
2) ne kazda mutace je skodliva
Varianty bez skodlivych mutaci "preziji" a mnozi se dal. Tohle vsechno jsou mutace, ktere bezi na pozadi epidemie, je jich obrovske mnozstvi a my vidime jen zlomek.
Read 11 tweets
Petr Svoboda Profile picture
Sep 21, 2020
Today at the Faculty of Science @UniKarlova. What a nice day for a PhD state exam. Six of them, actually. :-) Image
Three down, three to go. All three passed. :-)
After 7 hours, I'm really tired. We continue tomorrow. Four thesis defenses will fill up the entire day, hopefully four new doctors will be born. Image
Read 9 tweets
Petr Svoboda Profile picture
Sep 13, 2020
Grotesknim odrazem doby je, jak snadno si clovek snadno splete prohlaseni z parodickych uctu s moznymi vyroky jejich predobrazu. Novinarska satira konkuruje zpravodajstvi. Zpravodajstvi konkuruje satire. Takova komicka apokalypsa. Nebo apokalypsa komiku. :-)
Pravda nebo satira? Image
Pravda nebo satira? Image
Read 48 tweets
Petr Svoboda Profile picture
Jul 21, 2020
SRC @lborouniversity says: Each hour short of 8 hrs of sleep a night could knock one pt off a person's IQ. It would be easy to lose 15 pts in a week, resulting in a person with an IQ of 100 becoming "borderline retarded."

@AndrejBabis & @KarelHavlicek_ sleep deprivation contest
pubmed.ncbi.nlm.nih.gov/21518064/
pubmed.ncbi.nlm.nih.gov/10329298/
Read 4 tweets

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