This thread explains how @Novavax is different from the #Moderna and #Pfizer #mRNA #vaccines and describes some of the benefits such as broadened #variant recognition, more durable #immunity, and fewer side effects. 🧵1/
An unrolled one-page web view for this long thread that may be easier to read or share can be found here ( ). 2/
Novavax is a protein based vaccine (similar designs have also been used for many years for tetanus, diphtheria and hepatitis B). Novavax presents the full COVID-19 Spike protein in nanoparticles designed to mimic the structure of the virus itself ( ). 3/ novavax.com/science-techno…
mRNA vaccines on the other hand get your immune cells to produce copies of the full Spike protein as single Spikes on their own which may interact differently with the immune system than Novavax's multi-Spike arrangement around a core. 4/
This video shows you how the mRNA Spikes are produced in your body ( ). 5/
Another big difference between Novavax and the mRNA vaccines is that Novavax uses an adjuvant called Matrix-M made from the soapbark tree to enhance the immune response to the vaccine. 6/
This adjuvant induces early activation of innate immune cells at the injection site and in the draining lymph nodes ( ). H/T: @paulseaman31 7/ tandfonline.com/doi/full/10.10…
You can read the study to to get much more details about the mechanisms of action with Matrix-M, including interesting facts such as within 24 hours both the Spike antigens and adjuvant are undetectable at the injection site... 8/
...since they have already been processed and transported to the draining lymph nodes by immune cells. I wonder if that is one of the reasons why many people feel much less pain in their arms after injection compared to mRNA shots? 9/
Using Matrix-M translates into an improved magnitude and quality of the antibody response to the Spike protein (antigen) and importantly broadened recognition of locations on the Spike (epitopes). 10/
This improvement was actually seen in the real world with the BA.1 and BA.5 variants and the original Novavax vaccine formula. 11/
Both Pfizer and Moderna released bivalent BA.1/BA.5 vaccines in fall 2022 since the antibodies generated from their original mRNA vaccines could no longer neutralize these newer Omicron variants. 12/
Novavax however did not release a bivalent vaccine because their original vaccine formula with Matrix-M still worked with the BA.1 and BA.5 variants. 13/
The Matrix-M adjuvant elicited antibodies from a broader set of locations on the Spike protein (epitopes) so even when some of the locations mutated with BA.1 and BA.5, the conserved locations could still be recognized by the immune system. ( ). 14/ medrxiv.org/content/10.110…
There have also been suggestions to improve mRNA vaccine potency, durability, safety and T-cell response by using adjuvants ( ). 15/nature.com/articles/s4155…
In mice they found the adjuvant in mRNA vaccines increased antibody levels 10x and produced Fc-binding antibodies which showed better control over viral replication and help predict resolution of severed COVID-19 ( ). 16/
Many people have anecdotally discovered and reported that Novavax doses had much lower side effects than when they received an mRNA shot. 17/
Multiple studies have now shown this to be the case as well. One preprint study (supported by Novavax) that compares the reactogenicity (frequency of side effects) of Novavax and mRNA vaccines ( ). H/T: @michaelzlin 18/medrxiv.org/content/10.110…
They found a notable difference in the percentage of reported side effect symptoms with Novavax being lower in each category:
* 30.8% lower muscle pain
* 30.4% lower injection site pain
* 25.7% lower fatigue
* 25.4% lower injection site tenderness
* 24.9% lower malaise
What about people who had mRNA doses previously but want to consider Novavax? There have been several studies now that found mixing the two, getting mRNA and then Novavax actually gave better results than just mRNA on its own. 21/
One study found that getting Novavax as a booster after mRNA "may enhance the persistence and durability of vaccine-mediated immunity compared to mRNA options"... 22/
...with slower decay rate compared to an mRNA booster dose and less side effects than mRNA boosters ( ). H/T: @Daniel_E_Park 23/tandfonline.com/doi/full/10.10…
A randomized controlled trial found that getting a Novavax dose after Pfizer mRNA elicited the highest humoral and peak cellular immune responses ( ). H/T: @michaelzlin 24/journalofinfection.com/article/S0163-…
The mRNA + Novavax combination also had the lowest rate of breakthrough infections and the study also found fewer moderate and severe systemic adverse effects for Novavax than Pfizer mRNA. 25/
Neutralising antibodies against Omicron BA.1 and BA.2 were higher with Novavax after mRNA compared to two mRNA doses. 26/
Now you have more details as to how Novavax is different and some of the nice benefits including for people who had mRNA shots previously. 27/
I'm hoping that the Matrix-M adjuvant will again show its ability to broaden the immune system's ability to choose epitopes so that it might continue to work better for upcoming variants as it did when BA.1 and BA.5 emerged. 28/
FYI, I do not work for Novavax or have any investments or make any money from Novavax selling products. 29/
I am a little confused as to why @Novavax just recently filed their regulatory approval paperwork with Health Canada as many people are waiting for the fall boosters so it would be a shame if they were not available soon like the mRNA fall boosters are expected to be. 30/
While vaccines are important, they should be the last layer of protection to rely on in case all the other layers fail and you get exposed. Vaccines should not be the one and only layer governments all seem to be currently relying on. 31/ Click "Show replies" 👇 to continue.
ASHRAE Standard 241, Control of Infectious Aerosols ( ) was released in July 2023 so this should now be adopted and required in air quality standards for buildings like governments already require clean drinking water standards for these same buildings.32/ashrae.org/technical-reso…
It is important to have good indoor air quality, not just from viruses but also for cognitive function and from other air pollutants (like wildfire smoke) which have been linked to various health problems ( ). 33/
Aerosol and particulate matter (PM) particles can also be filtered and removed from the air using HVAC filters like MERV-13 or better, HEPA filters, build yourself CR-boxes with traditional fans or super quiet versions with PC fans. 34/
You can find guides and useful information on my website ( ). 35/covid.gilchrist.ca
Since you don't have control over the air quality in most public spaces you can also use personal filters (aka masks) with a good seal designed to protect from airborne pathogens like N95 respirators. 36/
To find out how well your mask seals, you can see my thread on fit testing ( ) and some of the test results I got comparing masks ( ). 37/
Some people misunderstand and think filters such as HEPA and mask material work like a sieve or chain link fence which allow smaller objects like flies to pass through. 38/
This thread explains how the laws of physics are used to allow the filtering material to stop such tiny smoke and aerosol particles ( ). 39/
You can see in the graph, COVID makes up the majority of new hospitalizations due to #Flu, #RSV or #COVID throughout the year, and even stays ahead during winter respiratory virus season. 🧵1/
New hospitalizations are increasing again. This last update was the first time Flu hospitalizations (42) were significantly higher than COVID (34) in the same week with RSV at 14 people. 2/
In Ottawa, test positivity for Flu A (bright green) has really increased, COVID is still in second place, but seasonal human coronavirus is almost the same level, followed by Entero/Rhinovirus, and then RSV for the top 5. 3/
Similar to #Canada, babies in the #UK are at higher risk for #hospitalization and #ICU admission from #COVID. Their data looks deeper at infants < 6 months old which have higher ER attendance, hospital admission and severe hospitalisation rates than the oldest adults 90+! 🧵1/
In Canada, babies < 1 years old had the highest ICU admission rates of all age groups from Aug. 27, 2023 to Aug. 24, 2024. Read on to see more details including Flu and RSV too ( ). 3/
The @elastomaskpro () is a NIOSH approved reusable N95 elastomeric respirator. It is made of silicone so a higher chance it will fit and seal well and is super breathable at the same time. Read on to find out more about my experience with it. 🧵1/ elastomaskpro.com
Full disclosure: ElastoMaskPro sent me a unit to evaluate. There were no strings attached, they just asked that I provided feedback after I tried it. This thread is the first time they are seeing my feedback, they did not review anything before it being posted here. 2/
The ElastoMaskPro is very cost effective at the current sale price of $29.99 which includes two N95 filtering pucks. You can continue using the filters until they either get too dirty or there is increased breathing resistance. 3/
Ottawa updated its #respiratory #virus data again after a break for the holidays, respiratory related ED visits are up especially in kids 0-3, then 4-11 and age 80+. 🧵1/
Quite a mixture of different viruses testing positive in the lab right now so people can pick up a variety of bugs in the air. 2/
New hospitalizations also jumped a lot in the last two reporting weeks, not just due to #RSV but a big spike in #COVID as well.
#Variant update for #Ontario, #Canada (to Dec 10, 2024)
The KP.3.1.1 #DeFLuQE variant has finally been surpassed with XEC now in top place above 20% while the other 5 (MC.* and XEC.* descendants) remain < 7%. Graph tools by @Mike_Honey_ 🧵1/
XEC is a combination of KP.3.3 and KS.1.1 that recombined together. MC.1 is a direct descendant of KP.3.1.1 with one spike mutation at T571I. To learn more about how variant naming works, you can read this article I wrote with @paulseaman31 ( ). 2/docs.google.com/document/d/1q0…
This Sankey graph shows the proportion of variants from PCR test genomic sequencing in Ontario since October 27, 2024. You can follow the lineage backwards to see where a variant is a descendant from. 3/
This is a good example of why it is useful to understand the importance of population *rate* and not just look at raw numbers. The first graph shows raw numbers and the second graph population rate. 🧵1/ #ED #Respiratory #Virus #Population #Ottawa
Ottawa Public Health makes only the raw data available for All causes and respiratory-related emergency department visits to Ottawa hospitals by age group and week ( ). 2/open.ottawa.ca/datasets/ottaw…
If I take the data and plot all the ages together, you can at least see all of the age groups at the same time but it is just the raw numbers. 3/