AJ Leonardi, MBBS, PhD Profile picture
Sep 15 5 tweets 1 min read Twitter logo Read on Twitter
1) Senior immunologists said I was wrong that infections posed the risk of widespread T cell exhaustion and called it "twitter nonsense"

2) They said I was wrong that the experience in severe disease shared the spectrum of mild disease, despite sharing mechanism
3) They said I was wrong about Fas-mediated apoptosis

4) They said I was wrong that reinfections would continue to hyperactivate T cells

5) They said I was wrong about the prospect of rapid evolution and antigenic escape
6) They said I was wrong that ace2 affinity would increase after Omicron

7) They said I was wrong that covid harmed the immune system

8) They said I was wrong that immune dysregulation underlies Long Covid
9) They said I was wrong about chronic T cell activation posing a risk to the population
I keep seeing studies about exceptional qualities to infection

There are epigenetic programs that are unseen in both sepsis and lethal flu.

• • •

Missing some Tweet in this thread? You can try to force a refresh
 

Keep Current with AJ Leonardi, MBBS, PhD

AJ Leonardi, MBBS, PhD Profile picture

Stay in touch and get notified when new unrolls are available from this author!

Read all threads

This Thread may be Removed Anytime!

PDF

Twitter may remove this content at anytime! Save it as PDF for later use!

Try unrolling a thread yourself!

how to unroll video
  1. Follow @ThreadReaderApp to mention us!

  2. From a Twitter thread mention us with a keyword "unroll"
@threadreaderapp unroll

Practice here first or read more on our help page!

More from @fitterhappierAJ

Aug 4
The virus has not turned into an ordinary illness

Symptoms are from the immune response and appreciated grossly (eg cough, chills, headache, fever)

Pathophysiology tells a different tale of effects Cov2 has that ordinary illnesses don't

🧵
For example, even extreme lethal cases of flu do not send T cells into the brain

SARS Cov 2 does

https://t.co/gxSHkoJ5Z1nature.com/articles/s4158…
Image
Scientists examined T and B cell changes after infection with normal viruses versus covid.

Only Covid, not the normal viruses, caused missing unactivated naive T and B cells Image
Read 6 tweets
Jun 10
The claim Long Covid rates would reduce upon reinfections were made by Iwasaki, Zeynep, and others

When I said I believed the opposite I was derided and mocked

Three studies now show increasing rates of Long Covid on reinfection

🧵

ImageImageImageImage
I was mocked as not a subject matter expert by the established in the field like Rupert Beale. Zeynep would tag 15+ immunologists below me

Before I was mocked as "not Galileo" because I claimed there would be no herd immunity to Covid before Omicron
Image
It’s strange that experts went on record saying reinfections would result in lower rates of Covid

I would have to reduce the considerations of what creates long Covid into a maybe 12 kB string of thought in order to make the same conclusion
Read 7 tweets
Jun 4
Hello

I am the only person who said there would likely be increased rather than decreased rates of long covid upon reinfection due to cumulative effects on the immune system and organs

Several studies recently corroborated this
Recently, I made a statement that lifetime rates of long Covid would be over 99.9%.

Most people erroneously took this as a Percentage of the population affected, which it would not be

Some people would get long Covid several times others, not at all
This is easy to understand, however, some people that do not understand it have very strong opinions

This led me to realise that in instances where precise language and proper conceptualization are necessary, especially when things are counterintuitive, one will stand outside
Read 6 tweets
May 28
Both Ladhani's and the NIH's Long Covid studies show the idea that Long Covid probability goes down with reinfection because your "immune system fortifies with exposure" is false

This was yet another piece of wishful thinking that I stood against

nytimes.com/2022/08/12/opi…
1/7 Image
You may remember when reinfections were claimed unlikely, and immunity would be lifelong similar to SARS 1

I claimed it was possible sars2 would mutate quickly out of it

This is yet another example of being overly optimistic and not accounting for facets of sars cov2

2/7
This presents a great challenge to society and its people at large

With similar rates of LC between infection and reinfection, the tally of people too ill to work steadily increases

What it means for you is that it could be more likely than not that you get Long Covid soon

3/7
Read 8 tweets
May 27
All throughout medical school, I have faced Marc Veldhoen and Bertoletti calling me things from "depressed" to "grifter," and mocking me for stating that SARS Cov 2 infection can cause T cell harm

Here Zeynep Tufekci acknowledges the article is pointed at my "looney" theories ImageImageImageImage
If the investigation finds that the "fit and happy" title has nothing to do with a directed critique against me, it will have been a sham ImageImageImageImage
I cannot get more from Veldhoen's account as he made it private, but he had Xs on my posts calling me a grifter
@ImmunolCellBiol @LabListon
ImageImageImage
Read 5 tweets
May 26
Risk of long covid accumulates via reinfections if the graph is assumed to be correct, meaning it is not one group of susceptible people as others have said

The new LC studies corroborate a cumulative model versus susceptible model of Long Covid risk ImageImage
The "susceptibles" model of Long Covid was harmful to patients with Long Covid AND incorrect

It postulated that people with LC had some genetic susceptibility for their problem, and this effect would not be seen in the wider population

It's shown false
Image
I believe it is not only ableist, but downplays the risk that 'normal healthy people' face for Long Covid

Image
Read 4 tweets

Did Thread Reader help you today?

Support us! We are indie developers!


This site is made by just two indie developers on a laptop doing marketing, support and development! Read more about the story.

Become a Premium Member ($3/month or $30/year) and get exclusive features!

Become Premium

Don't want to be a Premium member but still want to support us?

Make a small donation by buying us coffee ($5) or help with server cost ($10)

Donate via Paypal

Or Donate anonymously using crypto!

Ethereum

0xfe58350B80634f60Fa6Dc149a72b4DFbc17D341E copy

Bitcoin

3ATGMxNzCUFzxpMCHL5sWSt4DVtS8UqXpi copy

Thank you for your support!

Follow Us on Twitter!

:(