Thread by @ejustin46

IMMUNE IMPRINTING !

It is strange that almost no one (except @MarionKoopmans) has talked about the latest study by @yunlong_cao and his colleagues, on this subject 🤔

2) "Repeated Omicron exposures override ancestral SARS-CoV-2 immune imprinting"


Key findings :

▶️ "Immune imprinting induced by wildtype (WT)-based vaccination would compromise the antibody response to Omicron-based boosters"biorxiv.org/content/10.110…

3) ▶️ Single Omicron-boosting is heavily limited by immune imprinting, especially when using variants antigenically distinct from WT, like XBB"
▶️ "Repeated Omicron infections could also alleviate WT-vaccination-induced immune imprinting and generate high neutralizing titers ...

4) ...against XBB.1.5 and XBB.1.16"
▶️ "Our findings suggest the WT component should be abandoned when updating COVID-19 vaccine antigen compositions to XBB lineages, and those who haven’t been exposed to Omicron yet should receive two updated vaccine boosters."

5) Fig. 2 | Humoral immune imprinting after repeated Omicron infections in humans.

6) Fig. 3 B cell immune imprinting after repeated Omicron infections.

7) Fig. 4 Epitope distribution and characterization of mAbs elicited by Omicron BTI and reinfection

8) Fig. 5 | Estimate the evolutionary trends of XBB.1.5 RBD from DMS profiles.

9) Fig. 6 Combination of escape mutations evades XBB.1.5-neutralizing antibodies from reinfection.

10) Extended Data Fig. 7 SPR sensorgrams for affinity of hACEZ and SARS-CoV-2 mutants RBD

11) Thanks for reading 🙏 and let see the reaction of the experts on this subject 😁

FYI
@LongDesertTrain @siamosolocani @SystemsVirology
@AltenbergLee
@mrmickme
@DavidJoffe64 @HarrySpoelstra
@UseBy2022 @outbreakupdates @arijitchakrav
@C_A_Gustave
@UseBy2022
@vipintukur