Daniel Brittain Dugger Profile picture
Sep 20 29 tweets 7 min read Twitter logo Read on Twitter
Since you asked what other similarities exist, let me reference my Why SARS-Cov-2 Is Deserving Of Having The Playbook Used For The Prevention, Treatment, And Management Of HIV Applied To It document.
With both infections, one of the first things that is accomplished is a breaking down of the Intestinal Barrier Function, allowing for what is referred to as microbial translocation to take place. Image
Once "leaky gut" develops, lipopolysaccharide enters systemic circulation, placing the immune system under constant stimulation. This also leads to a premature aging of the immune system and contributes to neurocognitive decline. frontiersin.org/articles/10.33…
Another similarity is that of reservoir involvement, which was known to the government, medical establishment, academia, and advocacy groups in September, 2021. assets.researchsquare.com/files/rs-11390…
Lots of folks have complained of dysautonomia. This is seen in HIV positive individuals who have virus in the second portion of the small intestine, or jejunum. Chertow found virus there in 2021. ncbi.nlm.nih.gov/pmc/articles/P…
"Pathologic studies involving the jejunal mucosa of HIV-positive patients demonstrates that damage to the autonomic nerve fibers occurs early in the course of HIV infection."
Both populations can experience osteoporosis as a consequence of monocyte derived macrophages differentiating into hyperactive osteoclasts. medicine.iu.edu/blogs/research…
This is why folks jaws are disintegrating. The mandible is rich in osteoclasts.
You hear of folks talking about their teeth falling out and cavities developing. This is due to a lack of saliva production because the salivary glands have been infected. pubmed.ncbi.nlm.nih.gov/33834497/
"Chronic hyposalivation occurring in almost 30-40% of HIV infected patients is another important factor increasing the risk of tooth caries."
Both populations can experience what has been referred to as "microclots" but is actually disseminated intravascular coagulation. Viral persistence, leaky gut, and other factors cause the clots to form. Image
Both populations experience latent virus reactivation. Your population is experiencing Immune System Reconstitution Inflammatory Syndrome due to low neutrophils. HIV folks can experience it after antiviral initiation. ncbi.nlm.nih.gov/books/NBK56780…
Both populations can experience amyloid being deposited int the brain. pubs.acs.org/doi/10.1021/ja…
Both populations experience cell-to-cell communication, or transcytosis. One example is that of the Tunneling Nanotube. science.org/doi/10.1126/sc…
Both populations experience cachexia and sarcopenia. onlinelibrary.wiley.com/doi/10.1002/jc…
Both populations can experience an elevation in Vascular Endothelial Growth Factor, which contributes to angiogenesis, or new blood vessel formation, feeding tumors. academic.oup.com/oncolo/article…
Both populations can experience the exact opposite of DIC, Immune Thrombocytopenia Purpura. ncbi.nlm.nih.gov/pmc/articles/P…
Both populations have had their neurological insult measured with the test for HIV Associated Neurocognitive Decline. ucsf.edu/news/2022/01/4…
Both populations have those who are suffering from Asymptomatic Neurocognitive Impairment and do not even know it. Like 70% of Dr. Apple's control arm.
Both populations have had astrocytes, perivascular macrophages, choroid plexus, pericytes, and microglia infected within the Central Nervous System reservoir.
Microglia are the primary cell type that constitute the CNS reservoir in HIV. They are resistant to death and contribute to drug resistance. ncbi.nlm.nih.gov/pmc/articles/P…
There is also an aversion to the use of nonpharmaceutical interventions and vaccines that do not prevent against infection.
There is only one population that is able to prevent further disease progression and forward transmission.
This was made possible due to strong advocacy by those who sought to keep their donors alive for decades, like Nashville Cares that has been around since the early days of the HIV crisis.

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More from @dbdugger

Sep 22
Unfortunately, a large number of individuals, including those in the medical establishment and academia bought into the idea of it being "post infectious" and a consequence have inflicted significant immunological harm of millions of individuals, our intellectual capital.
"Post viral" and "Post infectious" implies that the virus no longer exists and/or that the virus cannot be transmitted to another in a forward direction.
We know that it is neither "post viral" nor "post infectious" for a number of reasons. First, we have seen essentially every single monoclonal therapy wiped out.
Read 22 tweets
Sep 21
We have known for years that every cell type that constitutes the Central Nervous System reservoir in HIV is productively infected by SARS-Cov-2.
How many may have satisfied the diagnostic criteria for Asymptomatic Neurocognitive Impairment, like those in Dr. Apple's study but were left to suffer further disease progression because people called it ME/CFS.
Read 4 tweets
Sep 21
A chronic SARS-Cov-2 infection is brand new. There has been inaction due to the gross incompetence displayed by "advocates" who took it upon themselves to jump into the deep end having not spent enough time in the kiddie pool.
Despite the fact that there are a number of journal articles speaking to the depletion of the CD4 compartment, there has yet to be one advocacy group address the issue.
Neither have they taken it upon themselves to learn about critical concepts such as the Estimated Date of Seroconversion nor the CD4 nadir.
Read 10 tweets
Sep 21
And we have data on reservoir penetration rates, specifically the CNS.
For fuck’s sake, could have been so simple, lmao
Read 8 tweets
Sep 18
Ideally, we would divorce ourselves from a monotherapy that belongs to a drug class known for significant side effects. Combination therapy, to guard against resistance, will be required for life, in light of reservoir involvement.
Protease inhibitors are disfavored in HIV medicine, folks. Why? Because of the side effects. Ironically, Paxlovid is boosted with Ritonavir, known to contribute to that which everyone complains about: endothelial damage.
Read 9 tweets
Sep 17
As a member of the HIV community, it was quite easy for me to step into the role of an advocate for those living with a chronic SARS-Cov-2 infection because of the similarities between the two chronic infectious illnesses. In the middle of a pandemic, you draw parallels.
September 28, 2020, the government, academia, medical establishment, and advocacy groups were alerted to the fact that SARS-Cov-2 possessed the same ability of HIV to deplete the CD4 compartment. medrxiv.org/content/10.110…
This article could have triggered a reliance upon forty years of evidenced based medicine to preserve the immune competence and cognition of that which our economy relies, our intellectual capital.
Read 30 tweets

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