Thread by @ejustin46

SARS-CoV-2 uses similar strategy to HIV to INFECT DEFENSE CELLS !

2) CD4 (cluster of differentiation 4) is a glycoprotein that serves as a co-receptor for the T-cell receptor and found on the surface of immune cells such as T helper cells or macrophages. HIV binds to the CD4 molecule on the surface of helper T-cells and replicates within them.

3) Our results suggest that in some patients the novel coronavirus can cause acute immunodeficiency not only by killing some of the subject’s CD4+ T lymphocytes but also by impairing their function.
agencia.fapesp.br/sars-cov-2-use…

4) The left-hand image shows RdRp, an enzyme from SARS-CoV-2 that regulates viral replication (stained red), inside a CD4+ T lymphocyte. The right-hand image shows the SARS-CoV-2 spike protein (green) near the cell membrane (image: Henrique Marques-Souza / UNICAMP)

5) The study of reference

Fig. SARS-CoV-2 infects CD4+ T cells in vitro and in vivo. elifesciences.org/articles/84790

6) For those interested in this subject, we have posted several threads on the subject of CD4+ T-cells.

https://twitter.com/ejustin46/status/1657577827775000577?t=vEbCL2f6tkPctAnFLKKHAg&s=19

7) CD4+ t-cells senescence...

https://twitter.com/ejustin46/status/1688813526024859653?t=AmuZE3RMe-KW5kdaxBLBcg&s=19

8) And more generally on the subject of T-cells

https://twitter.com/ejustin46/status/1702183341573734663?t=LOBcugqnmc6GcqVy9GuLvA&s=19

9) Thanks for reading 🙏

We will try to explain in another thread why this mechanism does not work with bats.
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