Thread by @Patent_SUN

THEME: #CTCCTCGGCGGGCACGTAG
Moderna's 19 nucleotide sequence in patent

It is known that the COVID19 includes the nucleotide sequence of "CTCCTCGGCGGGCACGTAG" in its furin cleavage site, and that Moderna has the reverse complementary sequence thereof in the Sequence Listing attached to their patent specification. The reverse complementary sequence is "CTACGTGCCCGCCGAGGAG."

It is said that the probability that the "CTCCTCGGCGGGCACGTAG" naturally appears in the COVID19 may be "3e-11."



The following five patent publications ① to ⑤ each includes the above reverse complementary sequence in its Sequence Listing, but no patent rights have been granted to the reverse complementary sequence itself.

①US9149506B2
②US9216205B2
③US9255129B2
④US9301993B2
⑤US9587003B2

Therefore, we must carefully explain the reverse complementary sequence so as not to mislead the public. Regarding those patent publications ① to ⑤, by referring to the "We claim" section (scope of Claims) attached to the end of each specification, we can understand where the patent rights exist.

As we can see in each "We claim" section of the patent publications ① to ⑤, there is no description of "CTACGTGCCCGCCGAGGAG."

From this fact, we can understand that the patent rights have NOT been granted to it.

If you have different patent information regarding this, please let me know.

-1-

The Sequence Listing cannot be obtained just by obtaining the patent publications ① to ⑤.

How can we get and confirm the Sequence Listing?
We can obtain it by accessing the United States Patent Office () and entering any one of the following patent numbers ① to ⑤.

①US9149506B2
②US9216205B2
③US9255129B2
④US9301993B2
⑤US9587003B2

Amazingly, this Sequence Listing contains "33,915 number of SEQ IDs" consisting ridiculous "1,431,049 number of total lines."

The "CTACGTGCCCGCCGAGGAG" can be found in a part of "SEQ ID: 11652."

-2-seqdata.uspto.gov

As attached to the previous post, the reverse complementary sequence merely forms a very small portion (only 19 bases) of the "SEQ ID 11652." Therefore, there is a question whether Moderna would have dared to extract this and obtain a patent.

If there was a plan to obtain a patent for the "CTACGTGCCCGCCGAGGAG," this should be clearly stated at least somewhere in the patent publications ① to ⑤. However, probably, there is no suggestion of this sequence anywhere in the patent publications ① to ⑤.

Personally, I think this is the most scary point about the patent publications ① to ⑤. That is, it is suspected that a MAD scientist cannot help but obtaining the problematic 19-base sequence only from the "33,915 number of SEQ IDs."

Assuming that the MAD scientist tries to integrate the "CTCCTCGGCGGGCACGTAG" into a progenitor virus of the COVID19 from zero knowledge, it is not enough for the MAD scientist to just read the patent publications ① to ⑤.

The MAD scientist has to undergo many steps.
First of all, the MAD scientist has to access the Sequence Listing. Next, the MAD researcher has to confirm "33,915 number of SEQ IDs" one by one and study their detailed functions. Next, the MAD scientist has to find out the reverse complementary sequence included in the "SEQ ID: 11652" and inverse it to the "CTACGTGCCCGCCGAGGAG" thereafter.

In order to avoid patent disputes, companies generally refer to the scope of the patented Claims. However, as far as the patent publications ① to ⑤ are concerned, there is no patent right for the reverse complementary sequence itself, and thus there is no motivation to focus on "SEQ ID: 11652" or the reverse complementary sequence itself.

-3-

Did the MAD scientist overcome such obstacles in their daily works and confirm the "33,915 number of SEQ IDs" one by one?

Imagine. Can you do this? How long does it take?

Considering these circumstances, it must be said that the knowledge of the MAD scientist far exceeds that of ordinary scientist. It is thus rational to suspect that the MAD scientist had prior knowledge of the reverse complementary sequence.

If the reverse complementary sequence had been reported separately in a paper, etc., it might be easy to integrate it into the progenitor virus.

As a matter of course, it is also possible that this is just a coincidence. In this case, I sympathize so much with Moderna for the unfortunate accident.

To understand this issue more, we also need to know the function of "SEQ ID: 11652" (or a part of it). I do not know whether the function of the "SEQ ID: 11652" is the same as that of the furin cleavage site of the COVID 19 or not.

If those functions are completely different, the probability of the coincidence will become high, but if those functions completely match, the probability of the work of the MAD scientist will become high.

-4(END)-