What if SARS-COV-2 MANIPULATED US, to SPREAD BETTER ?
2) There is always the risk with such hypotheses of being accused of anthropomorphism, i.e. lending human behaviors to a virus which cannot have any.
However, there have been several interesting studies on this subject and particularly in the field of behavioral neurovirology.
3) In fact, such behaviour-changing effects of viruses – so-called behavioural host manipulation – are not new, and have previously been reported for some viruses.
The theory is that pathogens do this to maximise their reproduction rate and in turn, their spread and survival.
4) The example of rabies virus :
"When a host is infected with the rabies virus it gets into the host’s central nervous system and triggers hyper aggression. The virus is also present in the rabid animal’s saliva ...
5) ... so being bitten transmits the infection to a new host and the old host is left to eventually die if untreated."
6) In a first study, they "hypothesized that the novel coronavirus, SARS-CoV2, which produces the COVID-19 disease may produce host manipulations that maximize its transmission between humans." ncbi.nlm.nih.gov/pmc/articles/P…
7) First hypothesis :
The virus may act on an area of the brain called the anterior cingulate cortex (ACC), which is involved in social behaviour and emotional regulation. By manipulating the ACC, instead of observing distancing rules, people would be drawn to "gather socially"
8) Second hypothesis :
"While there are effects on behaviour through virus-induced changes in the nervous system, Covid has the potential also to change the endocrine system that produces hormones that regulate many functions, from sleep to reproduction and social behaviour"
9) In another study, they show that SARS-COV-2 "bind to the host receptor neuropilin-1 in order to gain entry into the cell" but also can cause "interferon suppression and the resulting reduction in sickness behavior ...
10) ... enhanced transmission through neurally mediated cough induction, and reduction in sense of smell." link.springer.com/article/10.100…
11) We had already mentioned this hypothesis in particular because of the impact of the virus on dopamine.
12) Of course, these remain hypotheses but clearly the virus has more than one trick up its sleeve.
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IS SARS-CoV-2 BECOMING "INVISIBLE"? The Hidden Truth Behind the Pandemic
As the world strives to move past the COVID-19 pandemic, a troubling narrative has emerged: the perception that SARS-CoV-2 is becoming "invisible."
2) Governments and communities are eager to return to normalcy, leading to a tendency to downplay the virus's severity. Reports of new infections and long COVID cases have been totally minimized, creating a false sense of security ...
3) ...that the virus is no longer a significant threat. However, this perception is not only a matter of public sentiment. The virus itself has evolved, most notably with the emergence of the Omicron variant. Recent research reveals that Omicron exhibits a remarkable ability ...
2) This research shows that SARS-CoV-2, the virus that causes COVID-19, stops infected cells from dying. Normally, when cells die, it helps stop viruses from spreading. By keeping these cells alive longer, SARS-CoV-2 allows itself to multiply and also helps other viruses ...
3) ... like influenza A, grow more easily.
When someone has both SARS-CoV-2 and influenza A, the two viruses can make a person much sicker. The immune system gets overwhelmed, leading to more inflammation and damage to the lungs.
ENTROPY UNLEASHED:
How Viral Protein Interactions Drive Coronavirus Adaptation in Bats and Humans
Entropy, in a general sense, refers to the level of disorder or randomness in a system. biorxiv.org/content/10.110…
2) When we talk about protein interactions and viral behavior, entropy can be viewed as a measure of how complex and varied these interactions are.
In the context of the study about coronavirus interactions in bat and human cells, here's a simplified breakdown.
3) **Complex Interactions**: The study identifies how proteins from the coronavirus interact with host cells (both bats and humans). These interactions can be highly ordered (low entropy) or more chaotic (high entropy).
Patients care most about how COVID-19 affects their health and daily life, including for those with long COVID. Scientists focus on understanding the virus to find better treatments. Both views are important for dealing with the pandemic.
2) I'm bringing up this topic because, after talking so much about the disease, its long-term effects, treatments, and vaccines, many people have forgotten that we are dealing with the most dangerous virus humanity has ever faced.
Organelles provide the possibility for the virus to organize its RNA in PROTECTED structures, concentrate REPLICATION machinery ... nature.com/articles/s4146…
2) ...compartmentalize the replication process, and hide from immune detection.
Figure 1g - The large perinuclear clusters of viral RNA demonstrate how the viral RNA is organized into PROTECTED structures.
2) Figure 3d- The nanoscale puncta of the viral RNA-dependent RNA polymerase (nsp12) within and around the viral RNA clusters show the concentration of REPLICATION machinery.