Marion Holman Profile picture
Oct 8 8 tweets 2 min read Twitter logo Read on Twitter
1/8 One of the vital roles of Vitamin C is to act as an antioxidant to protect cellular components from free radical damage. Vitamin C has been shown to scavenge free radicals directly in the aqueous phases of cells and the circulatory system. /2
2/8 Unlike Statins, Vitamin C has been proven to protect membranes & other hydrophobic compartments from such damage. Human subjects with low Vitamin C levels have been reported to have higher amounts of lipid peroxides in plasma than do subjects with high vitamin C levels. /3
3/8 It has also been shown that Vitamin C, may act as a preventive antioxidant against metal ion–mediated LDL oxidation.

Along with the reduction of sugar/seed oils in the diet there is another measure everyone can take to reduce their risk of heart disease. /4
4/8 That is the intake of supplemental Vitamin C.
An increased intake of Vitamin C decreases Total cholesterol, LDL-C and Triglycerides and increases HDL cholesterol.
Total cholesterol is regulated by Vitamin C in several ways. Vitamin C increases the rate of removal of
5/8 cholesterol from the blood by its conversion into bile acids.



This conversion involves hydroxylation reactions, for which ascorbate is in general required. In a study of patients with an average initial cholesterol level of
312 mg/dL whopubmed.ncbi.nlm.nih.gov/4685043/
6/8 were given 3 grams of Vitamin C daily for 3 weeks, the decreases in the cholesterol level was 18% and that in Triglycerides was 12% (Fidanza, Audisio, and Matroiacovo, 1982). The effect of vitamin C may be due to interference with either LDL oxidation or a process that is
7/8 induced by oxidized LDL. In short, Vitamin C is able to improve LDL resistance to oxidative modification.

Also interesting to note that Vitamin C prevents stress induced damage on the heart caused by the death of cardiomyocytes, /8
8/8 the cell responsible for the contraction of the heart.
pubmed.ncbi.nlm.nih.gov/23886864/

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More from @holmanm

Oct 7
1/9 The presence of a Lp(a) in species that have lost the ability for endogenous vitamin C production has been one of the unsolved puzzles of science. Particularly compelling is the fact that the appearance of Lp(a) about 40 million years ago coincided with the loss of /2
2/9 endogenous vitamin C synthesis by the ancestor of man. Based on this and other observations it has been proposed that Lp(a) functions as a substitute for vitamin C in stabilizing the Extracellular Matrix (ECM), particularly at times of prolonged nutritional scarcity. /3
3/9 If this concept is confirmed, any pathological condition related to vitamin C deficiency would involve Lp(a) as compensating factor. In a previous study we confirmed this concept for cardiovascular disease, where a prolonged deficiency of dietary vitamin C leads to the /4
Read 9 tweets
Oct 5
1/6 It’s patently obvious that the pharmaceutical industry would stop at nothing, even it involved harming people, to get their Statin gold-rush underway.

New medicines must first be tested on animals to ensure that they are safe enough to be given to humans. /2
2/6 Long story short, the broad variety of adverse effects of statins in many different animal tissues would not translate to toxicity in humans🙄. “These approaches of mechanism-based risk assessment predicted that most of the adverse effects observed in animals would not be /3
3/6 seen under conditions of human use” and so it was, that Statins were brought to market. Ignore the inconvenient. In fact, cover it up ! Don't even assess adverse events.
/4

pubmed.ncbi.nlm.nih.gov/15503662/
Read 6 tweets
Oct 4
1/7 While the greatest percentage of Statin adverse effects is muscle related, what appears to be muscle dysfunction can instead be injury to the nerves that innervate muscles. In this light, nerve related injury is the largest class of Statin induced injury.
/2
2/7 Cholesterol provides structure and a protective barrier to all cell membranes. The central nervous system (brain and spinal cord) makes up 23% of the cholesterol pool. This is because half of the brain matter is cholesterol and nerves are insulated with a protective wrap /3
3/7 called “Myelin” that is mostly cholesterol. Myelin is essential for the normal “firing” of nerve signals.

Experiments on rats with drugs that block the Mevalonate Pathway (Statins) demonstrate that interruption of cholesterol metabolism alters normal myelination of nerves /4
Read 7 tweets
Oct 2
1/11 Some people like liver. They eat it, but do not want anything eating theirs.

A very high percentage of statin injuries are due to liver damage. A predicable direct effect of statins and not a side effect or adverse drug reaction.

From the small intestines, Statins are
/2
2/11 absorbed into the blood & pass through the liver. While all organs make cholesterol, the liver generates most to make bile. Bile digests fat & is recycled to the liver. That makes the liver the “target organ” of Statins

By blocking reductase, liver cells receive a false /3
3/11 message that Mevalonate levels are “LOW” and reflexively produce more reductase. Elevated reductase in cells is toxic and stimulates the liver cell to make more LDL receptors that attract the LDL cholesterol from the dense blood tributaries that flow through the liver. /4
Read 11 tweets
Oct 1
1/5 All of our lives we have established patterns of belief, eating habits, who to trust, who not to trust, what is good, what is bad and many more — all of which may be wrong. How much can you change ? How far can you go ? Without courage we cannot take the first baby step, /2
2/5 let alone learn how to run. Courage is not the absence of fear. It is having fear and moving forward anyway.

Profits from drugs are made in obfuscation and complex constructs of the simple. If Statins had not been hugely profitable they would never have come to market. /3
3/5 The same is true of many other drugs. We frequently see another dangerous drug being recalled. That they are recalled is not a surprise. What is surprising is how they made it to market in the first place.

Only a force great enough can change the direction and spin of /4
Read 5 tweets
Oct 1
1/6 There are several types of glial cells in your brain & the nerves throughout your body. Each type has a special - and important-job in keeping your brain working at its best. The nervous system is composed of two major cell types: neurons and glia. Strikingly, glial cells /2
2/6 constitute 90% of cells in the human brain.
If these cells die, get damaged or are affected by a disease, it can cause major problems in your nervous system.

Astrocytes are a subtype of glial cells that make up the majority of cells in the human central nervous system. /3
3/6 They perform metabolic, structural, homeostatic, and neuroprotective tasks such as clearing excess neurotransmitters, stabilizing and regulating the blood-brain barrier, and promoting synapse formation.

The loss of astrocyte function has major implications for /4
Read 6 tweets

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