AJ Leonardi, MBBS, PhD Profile picture
Oct 14, 2023 10 tweets 5 min read Read on X
Since 2020 I have claimed that sars cov 2 infection would create harmed t cell memory based on phenotypes after infection

It is now proven

Even so, I have several Professors who pretend to not understand or do not understand how, nipping at my heels

I assume they behave this way because they are tenured & very mad, so they feel they can put their ignorance and vitriol on display wantonly

Bertoletti even made a nod to me in a publication, which the journal maintains references me in no way whatsoever


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For their benefit, I will list the publications that prove my thesis correct:

The first is how T cell responses derived from vaccination are superior to those derived from infection. T cell functions after infection were harmed. The publication is below:
The second proof is how people who were infected risked reinfection shortly afterward. That publication is here:


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This is consistent with the third publication, which shows the dampened CD8 T cell responses following infection. That publication is here:
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To address Kasper's category error: faster pcr negativity of a sars cov 2 infection upon reinfection is not proof that T cells or immunity have not been harmed.

Antibodies and b cell memory are largely contributing to clearance as well

You can look at t cells directly Image
The paper from the Danish Government is extremely poor and political

It claims people infected with cov 2 have less chance of infections with other illnesses, despite confessing how this is unexpected given derangements in the immune system following infection
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It also fails to repeat observed increases in other infections like tonsillitis after sars cov 2, which is another weakness this paper acknowledges

It is very poorly designed Image
In fact, we know a common post-viral complication is a bacterial pneumonia

The study could not reveal this, and in fact showed the opposite; that sars cov 2 protects

How could any conclusions be reliably drawn from the paper? It is poor science on parade. Image
It is not the only poorly designed paper

Some epidemiology studies have been designed where they sample a population biased by some metric, including age or working status

They are massaging the epidemiology

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More from @fitterhappierAJ

Jan 4
In August an immunologist declared the "Leonardi Effect" had received a "decent burial"

Fast forward to today: a new preprint shows what I warned about in 2020

Persistent SARS-CoV-2-induced impairment of CD8 T cell responses to community-acquired pathogens

I was right
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Key finding: Post-COVID patients show markedly reduced T cell reactivity to common pathogens (influenza, Staph, VCZ) which is evidence of lasting immune dysregulation favoring secondary infections and viral reactivation

Link:


2/5 biorxiv.org/content/10.648…Image
This is the scenario I described years ago: accelerated CD8 aging/paralysis/exhaustion/senescence, poorer control of pathogens.

We ignored it at our peril. Rising "mystery" infections, cancers, herpes flares? Not a coincidence
3/5 Image
Read 5 tweets
Jan 1
This BMJ highlight on movement from "immunity debt" to COVID's direct role in immune harm is a welcome shift

The evidence on T cell dysregulation driving secondary risks has been mounting and it's good to see mainstream outlets engaging it seriously
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In 2020 I argued against "debt", emphasizing Covid's lymphomanipulative pathways (T cell apoptosis, exhaustion, aging) causing immune harm

This drew massive ire
Labeled "crank"/"fraud," threats of op-eds pressuring labs, and a rescinded postdoc

I sacrificed hugely for candor
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Detractors confidently pushed alternate explanations and villified me back then

now, as data aligns with booming opportunistics, they're silent. no acknowledgment, no "perhaps we were harsh."
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Read 6 tweets
Nov 5, 2025
In 2020 I wrote a paper claiming the lymphopenia in Covid included Apoptosis, or T cell death

I made this "extreme" claim after reading the 1st paper on Covid's clinical course

Now, a paper claims ongoing T cell death is shaping population immunity
1/ link.springer.com/article/10.118…
Here they start by suggesting the immune system is aging from covid and that aged immune systems are vulnerable

In 2020 I projected that if reinfections would occur, then we would be left with population-level prematurely aged immune systems
2/ Image
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Their meta-analysis concludes Covid is causing sustained T cell death

There is an alternative hypothesis that reverses causality, but it is ridiculous

However, I claimed in 2020 immune harm from covid would ↑ susceptibility to a sera-evading variant
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Read 12 tweets
Jun 22, 2024
@Bryce_Nickels This is absolutely false because he made a “noble lie” and said the N 95s would not work for the public to the public in order for there to be greater supply to healthcare workers only. This backfired.
@Bryce_Nickels The ethical approach was the truth. This is a similar noble lie by omission that the WHO made when they refused to declare Covid as airborne in order for impoverished health systems to provide “adequate” PPE per their regulations according to WHO standards
@Bryce_Nickels The end result was workers in impoverished systems were being given “adequate “PPE for droplet transmission, and many of them died, including sadly many in New York City.
Read 4 tweets
Apr 6, 2024
When will H5N1 will go Human to Human?
Which is deadlier?
"The Covid pandemic has prepared me for an H5N1 pandemic"
Read 4 tweets
Mar 30, 2024
Wow looks like Marc is advocating Zero Covid, welcome Marc!

Mitigations like mask-wearing, clean air, and acknowledging the harm of covid infections

Well done!

This is an advancement from saying infections will maintain immunity, advocating for infection prevention instead Image
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Although it is a falsehood that vaccintions will not be needed

SARS Cov 2 is a Sarbecovirus and unlike the other common cold viruses. It has enhanced pathogenicity and immune evasion

Also, endemic sars cov 2 would INFECT the vulnerable, not protect them Image
I sure hope people didn't listen and abandon vaccinations after 1 infection because they thought reinfections would be like a common cold!
Read 5 tweets

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