I hope to post an interim Biobot-to-Verily PMC forecast Monday.
I stand by prior forecasts. We'll reach the bottom of the current (very high) valley in 1-2 wks. Cases will pick up noticeably so around mid-November and get very very bad in Dec/Jan.
Point of clarification: Verily data are included in this dashboard, but others have noted Verily does not own the dashboard. The language on their website is ambiguous in this regard, IMO (pic below). It's the first link on Verily's page.
Others report that as CDC Biobot sites come on, they will be included in a Verily-specific dashboard, independent of that above. It seems that rather than harmonizing and unifying data, we are at risk of proliferating more and potentially lower quality dashboards.
11/
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Biobot (blue) versus Verily (black) #wastewater data.
You'll see Verily data suggest the most recent wave (#7) has had considerably more transmission than Delta (#3). And that last winter (#6) was similar (or worse!) than the prior winter's BA.1 surge (#4).
Who wins?
1/
Here are the correlations among Biobot levels, Verily levels, & IHME true cases for the 1st of each month from Jan '21 to Apr '23.
Biobot correlates r=.94 (freakish) with IHME. Verily only correlates r=.67.
Either Biobot is much better, or Verily knows something we don't. 2/
The CDC awarded Biobot's contract to Verily.
Once Verily brings on Biobot's former CDC-contracted wastewater sites, that should help. Case estimation will be easier if they fold in the historic data to more accurately represent the nation.
U.S. #wastewater levels are higher than during 58% of the pandemic:
🔹 1.56% (1 in 64) are infectious
🔹 >745,000 C0VID cases/day
🔹 37,000+ #LongCovid cases/day
Click the full Tweet for more details on each forecast... 1/5
Wastewater levels are up from 505 copies/mL last week to 512 copies/mL this week. Before one screams "SURGE!!!," let's dig into the details. That's about as small an increase as possible, and well within the range of data corrections to real-time reports.
The Real-time model (red line):
It assumes that real-time data reports are accurate. However, real-time data often get corrected. Biobot and the CDC are currently in a transitionary phase of modifying when and which sites report, so I take the real-time data with a grain of salt. If it is accurate, however, the model suggests a rebound in cases, peaking around Oct 11, before bottoming out around Nov 1, before cases begin rising again for the winter wave.
Alt Model #1, Turtle (green line):
The turtle model ignores the most recent week's worth of data from Biobot, treating it as unreliable. Thus, it assumes that rather than a small increase this week, levels are actually continuing to decline and that corrections to real-time reports will later reflect that. It's essentially saying that the bump you're seeing in the real-time model is just noise. Cases will stay almost completely flat the next 6 weeks, with an official low point around Oct 25, before cases begin rising again for the winter wave.
Alt Model #2, Cheetah (orange line):
The cheetah model aims to correct for biases in real-time data reports. If last week's real-time report overestimated levels by 10% upon correction, it assumes this week's real-time report suffers the same bias. Last week's real-time report was quite accurate, so the cheetah model just looks close to the real-time model, same mini-peak, same valley, same rise in November for the winter wave.
Composite Model (black line):
This is the average of the three models. It's what's used for deriving all of the statistics reported. It basically suggests that cases will be mostly level at a high rate the next 6 weeks with minor fluctuations up or down. The composite model's take-home points are 1) continued high cases the next 6 weeks, 2) minimal fluctuation on a day-to-day basis during that time, 3) a low for the remainder of the year around Oct 25, and 4) a winter wave starting to pick up in mid-November.
Next Tweet, let's examine regional variation.
Regional variation suggests the need to pay attention for an increase unanticipated by the models.
The northeast is still rising steadily, and they are seeing 3-4x more FL 1.5.1 than other regions.
Caveat: this occurs during a time of Biobot/CDC reporting delays/issues.
2/5
Zooming out from the 6-month & regional views to the full pandemic, note we're in a steady state of high transmission between the 7th & 8th waves of the U.S. pandemic.
We will likely see at least 1.4% of the population actively infectious every day for the rest of 2023.
U.S. #wastewater levels are higher than during 58% of the pandemic:
🔹 1.55% (1 in 65) are infectious
🔹 >740,000 C0VID cases/day
🔹 37,000+ #LongCovid cases/day
Expect a high trough (600-750K cases/day) until a winter wave. 1/4
Let's zoom out from the 6-month view to the full pandemic.
The 7th U.S. C0VID wave has been huge, slightly smaller than Delta, & is now on the decline nationally.
We're seeing 5 million infections/week nationally, much higher than people realize, so continue with advocacy. 2/4
1.55% of the U.S. population is actively infectious with C0VID (Sep 20).
Schools and in-person work remain extremely risky.
If in the U.S., schedule a #booster. Go remote. #MaskUp. Read up on and improve indoor air quality. Avoid indoor dining. #RapidTest. 3/4
U.S. #wastewater levels are higher than during 64% of the pandemic:
🔹 1.8% (1 in 57) are infectious
🔹 >800,000 C0VID cases per day
🔹 >40,000 #LongCovid cases per day
Let's look at the good and bad of where we're heading....
The "Good" News:
Peaking. Transmission is slowing down a little and forecasted to decline further over the next month. If the Biobot data hold up against data corrections, the late summer wave peaked on August 30 at approximately 931,000 cases per day. By October 11, we expect to be closer to 700,000 cases per day. Less morbidity and mortality are always good news.
Modeling. Our models generally predicted that the peak would be sometime between Aug 23 and Sep 14, even amid some noisy wastewater data from Biobot. We regularly predicted that wastewater levels would fluctuate between 400-700 copies/mL from August to October, even amid much scolding and taunting from people who believed it would be much better or worse. The current forecasts show much convergence. The composite (black line) forecast is comprised of a real-time forecast (assumes Biobot's real-time wastewater data are accurate), turtle forecast (ignores the most recent week's Biobot data), and cheetah forecast (corrects the most recent week's Biobot data), all of which are quite similar at the moment. At present, this looks like a win for forecasting, with more improvements on the way. Good forecasts can help people make better predictions in an uncertain world.
Dissemination. The final bit of good news is that people are using this data to inform friends, their workplaces, and schools. In this regard, the time to act is NOW. People who do not follow wastewater are watching the anecdotal evidence in their lives pick up (personal reinfection, friends and coworkers infected, more masking, near-misses at schools, etc.). As reality glimmers through denial, now is the time to show people the data that validates what they are subjectively experiencing (still amid much second-guessing and gas-lighting). Anyone "flipped" toward watching the data will be much better prepared for the winter.
The Bad News:
High valley. Although a decline in transmission is always good, we're headed toward what is likely a very high valley in October at 700,000 infections per day, and then the picture will likely get much worse in November, December and January, unless we see an unanticipated level of vaccinations.
Grim Implications. In the "good" times of October, we will still see 1.5% of Americans (1 in 69) actively infectious at any given moment. Our low-end estimate suggests 35,000 new Long C0VID cases from such infections. That's grim.
Media narrative. The psychological dynamics are bleak. Expect the news media to focus on the fact that transmission is going down (the "good" news) instead of the much bigger picture that it's leveling off at very high rates (the very bad news). The over-optimism will likely undermine vaccinations and masking. The narrative should be "plan to take multi-layered precautions like using masks, getting boosters, and using remote options through January," but will more likely be "cases are headed back down."
If you're not mathematically inclined, use this table. Look up your county's #wastewater levels (on Biobot only, not other sites), and simply convert it to the % infectious estimate.
If wastewater levels are 1000 copies/mL, 3% of the county is infectious with C0VID. 2/
To precisely convert Biobot #wastewater levels to the % infectious, just take the Biobot levels and divide by 328. You'll get a percentage.
For example, national levels are at 641 copies/mL. 641/328 = 1.95. So, 1.95% of the U.S. is infectious. 3/