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Emmanuel Profile picture
@ejustin46
Oct 22, 2023 • 13 tweets • 4 min read • Read on X
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COVID-19: LONG-TERM MODIFICATIONS in the STRUCTURE of DNA !

This study has been posted several times but I would like to explain first in layman terms why it is a major study.
Some definitions :
EPIGENETIC changes refer to modifications in the structure of DNA ... Image
2) ... that do not alter the underlying genetic code but can influence gene expression.

HEMATOPOIETIC stem cells are responsible for producing different types of blood cells, including myeloid cells, which play a crucial role in the immune response. Image
3) In the case of severe COVID, the epigenetic changes influence gene expression patterns in the myeloid cells that are derived from these stem cells. The immune system of these individuals may undergo long-lasting alterations as a result of the COVID-19 infection. Image
4) The article in Nature :
nature.com/articles/s4142…
Image
5) The study (not really layman terms 🤷‍♂️) :

"Epigenetic memory of coronavirus infection in innate immune cells and their progenitors"
cell.com/cell/fulltext/…
Image
6) Altered chromatin accessibility and durable epigenetic memory in monocytes following COVID-19 Image
7) Durable epigenetic alterations in monocytes following severe COVID-19 Image
8) Durable changes in chromatin accessibility and expression in CD14+ monocytes following severe COVID-19 Image
9) Altered monocyte phenotypes and transcriptional programs post-COVID-19 Image
10) Hyper-responsiveness of post-COVID-19 CD14+ monocytes Image
11) Epigenomic and transcriptomic analysis of rare circulating HSPC establishes their similarity to BM HSPC Image
12) Anti-IL-6R blockade treatment dampens post-infection epigenetic memory Image
13) Thanks for reading 🙏
FYI
@DavidJoffe64 @white_bite @xabitron1 @RadCentrism @HarrySpoelstra @arijitchakrav @kasza_leslie @triangle24 @ramos262740691 @RolandBakerIII @outbreakupdates
@AltenbergLee @vipintukur
@RealCheckMarker @_ppmv Image

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More from @ejustin46

Emmanuel Profile picture
Apr 26
No, Omicron is not the "humanized" SARS-COV-2 !

(Explanation in simple terms)
biorxiv.org/content/10.110…Image
2) Viruses are not living things. They are tiny particles that can only make copies of themselves inside the cells of living things, like humans. When a virus makes copies of itself, it doesn't always make perfect copies.
3) Sometimes, little mistakes happen, and the new virus has a small change, or mutation, in its genes.

Most of the time, these mutations don't do anything useful for the virus. But every now and then, a mutation might happen that makes the virus better at infecting people. Image
Read 7 tweets
Emmanuel Profile picture
Apr 26
"What if humans had sent SARS-COV-2 into space, or even brought COVID-19 along for astronauts?"

biorxiv.org/content/10.110…Image
2) This study looks at the risks of COVID-19 for people traveling to space.

Space travel is becoming more common, with over 600 people having gone to space. But COVID-19 could be a big problem for astronauts in the unique environment of space. Image
3) The study aims to understand how COVID-19 might behave differently in space compared to on Earth.

The researchers reviewed studies on other airborne diseases in space. They found that some diseases, like Epstein-Barr virus and Serratia bacteria ... Image
Read 6 tweets
Emmanuel Profile picture
Apr 24
From Lung Damage to Gut Dysbiosis:
The Lasting Implications of SARS-CoV-2 Variant-Specific Microbiome Changes (From Wuhan strain to Omicron)
labanimres.biomedcentral.com/articles/10.11…Image
2) The Wuhan strain of SARS-CoV-2 caused serious damage to the lungs of infected mice. The mice had a very high chance of dying from this strain. The researchers also looked at the bacteria in the lungs and guts of the infected mice. Image
3) The Wuhan strain increased harmful bacteria like E. coli in the lungs. This can make the lungs more prone to other infections.

The Omicron variant caused different changes in the gut bacteria of the mice. It increased certain bacteria linked to inflammation in the gut. Image
Read 5 tweets
Emmanuel Profile picture
Apr 23
What are GAMMA CORONAVIRUSES ?
And why did we decide to talk about it? Image
Image
2) A brief reminder :

▶️ SARS-CoV-2 belongs to the family Coronaviridae, is classified as a coronavirus and is responsible for COVID-19
▶️ Bird Flu refers to various strains of the influenza virus, particularly those in the Orthomyxoviridae family including H5N1 and H7N9. Image
3) ▶️ Gammacoronavirus belongs to the family Coronaviridae like SARS-COV-2.

Some notable gammacoronaviruses include:
- Infectious Bronchitis Virus (IBV): A major pathogen in poultry responsible for respiratory disease and reduced egg production. Image
Read 10 tweets
Emmanuel Profile picture
Apr 21
A TREATMENT that Could Finally END Long COVID Suffering ?

This isn't the first time a treatment has been announced, and as millions continue to struggle with long Covid, we need to remain both cautious and hopeful 🤗 Image
2) Researchers at WEHI announced that they discovered a new drug that can stop long COVID symptoms in mice. This drug is more effective than the current top treatment, Paxlovid, for both long COVID and acute COVID cases. Image
3) They focused on a specific protein called PLpro that other treatments haven't targeted well. This breakthrough could lead to new medicines for long COVID, a condition where people continue to feel sick long after their COVID-19 infection. Image
Read 4 tweets
Emmanuel Profile picture
Apr 21
Experts Provide (finally !) Roadmap to Address the Complexities of Long COVID

... with top experts👍as @AndrewEwing11 @DavidJoffe64 and the Long COVID consensus expert panel 💥💯
ann-clinmicrob.biomedcentral.com/articles/10.11…Image
2) Long COVID is a complex condition that affects many people after they have had COVID-19. It can cause a wide range of symptoms that last for a long time. There are not many clear guidelines on how to diagnose and treat Long COVID. Image
3) An international group of 179 experts from 28 countries worked together to provide recommendations on Long COVID. They used a survey method called the Delphi process to reach consensus on important issues. Image
Read 8 tweets

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