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Vipin M. Vashishtha Profile picture
@vipintukur
Nov 8 • 6 tweets • 2 min read Twitter logo Read on Twitter
Another study explores SARS-CoV-2 impact on the cognition. We still don’t know whether cognitive decline emerges with the onset of COVID-19 and whether it is more pronounced in patients with #LingCovid or severe COVID-19. 1/ Image
A longitudinal cohort study compared the cognitive performance of 276 patients with COVID-19 to that of 217 controls across 4 neuroinflammation or vascular disease-sensitive domains of cognition using data collected both before and after the pandemic starting in 2015. 2/ Image
Longitudinal models indicated a significant decline in cognitive throughput following COVID-19, after adjustment for pre-COVID-19 functioning, demographics, and medical factors 3/
The effect sizes were large; the observed changes in throughput were equivalent to 10.6 years of normal aging & a 59.8% increase in the burden of mild cognitive impairment

➡️ Cognitive decline worsened w/ Covid severity & concentrated in participants reporting #LongCovid 4/ Image
Conclusions:

1-Infection with SARS-CoV-2 is associated with cognitive impairment equivalent to 10.6 years of normal aging and a 59.8% increase in mild cognitive impairment 5/
2-LongCovid & severe disease appeared to accelerate the cognitive deterioration, especially in executive function. Cognitive impairment affects daily, occupational, & social functioning. 6/6

medrxiv.org/content/10.110…

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More from @vipintukur

Vipin M. Vashishtha Profile picture
Nov 9
IVIG effective for patients with #LongCovid

LongCovid is frequently present with neuropathic symptoms including numbness, paresthesias, etc consistent with small fiber neuropathy (SFN). Evidence suggests SFN may be the key pathological finding in LongCovid. 1/
A new study provides preliminary evidence that small fiber neuropathy (SFN) is responsive to treatment with IVIG. The SFN is linked with neurovascular dysregulation and dysautonomia. 2/

medrxiv.org/content/10.110…
Image
Many patients with LongCovid also have overlapping symptomatology with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and/or Postural Orthostatic Tachycardia Syndrome (POTS). Prior to the pandemic, ME/CFS and POTS have been linked to SFN. 3/
Read 5 tweets
Vipin M. Vashishtha Profile picture
Nov 8
Why certain populations or communities are more susceptible to Covid19 than others?
Which changes in human and virus proteins may make someone more likely to catch COVID-19? 1/
A group of researchers predicted that some human genetic factors could influence susceptibility. They analysed missense coding variants in several SARS-CoV-2 proteins and its human protein interactors that could enhance binding affinity to SARS-CoV-2. 2/ Image
They studied 468 missense variants from human proteins and 212 variants from SARS-CoV-2 proteins and computationally predicted their impacts on binding affinities to SARS-CoV-2 proteins. 3/ Image
Read 9 tweets
Vipin M. Vashishtha Profile picture
Nov 3
Human immune responses similarity against different coronaviruses may reflect some degree of cross-immunity.
Whether previous MERS-CoV infection provides protection against a subsequent COVID-19 disease & its related outcomes? 1/
A retrospective study among all patients screened for MERS-CoV in Saudi Arabia between 2012 and early 2020. Both MERS-CoV positive and negative patients were followed up from early 2020 to September 2021 for developing COVID-19 infection confirmed by RT-PCR testing. 2/
397 subjects followed for 15 months during COVID pandemic (4.9 years from MERS-CoV infection). Of the 397 participants, 93 (23.4%) were +ve for MERS-CoV at baseline; 61 (65.6%) of the +ve cases were symptomatic. Out of 397, 48 (12.1%) developed COVID by the end of follow-up 3/ Image
Read 9 tweets
Vipin M. Vashishtha Profile picture
Nov 2
SARS-CoV-2 infection during early weeks of gestation linked to a significant upsurge in the incidence of an extremely rare entity-Situs inversus! 1/
Image
Image
Researchers from Shanghai, China noted a striking increase in the number of cases of fetal situs inversus at different hospitals several months after the “zero-Covid” policies in China were lifted. 2/ Image
Though vertical transmission of SARS2 is debated, fetal infection early in gestation could affect visceral lateralization; alternatively, SARS2–mediated maternal inflammatory responses might indirectly affect left–right organizer function and impair visceral lateralization. 3/ Image
Read 4 tweets
Vipin M. Vashishtha Profile picture
Oct 31
What causes Natural Killer(NK) cells dysfunction in severe COVID-19?

NK cells in severe COVID exhibit a unique profile characterized by activation & dysfunction. Studies have identified soluble factors, including type I interferon & TGFβ, that underlie this dysregulation. 1/
Image
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Now, a new study finds that NK cells are predicted to interact most strongly with monocytes and that this occurs via both soluble factors and direct interactions. 2/
Researchers conducted an experiment in which NK cells from healthy donors were incubated w/ monocytes from COVID19+ or healthy donors. Co-culture of healthy NK cells w/ monocytes from COVID patients recapitulated aspects of the NK cell phenotype observed in severe COVID-19. 3/ Image
Read 7 tweets
Vipin M. Vashishtha Profile picture
Oct 30
Ongoing SARS-CoV-2 evolution has given rise to the emergence of hypermutated variants like BA.2.86. In this context, durable and cross-reactive T-cell immune memory is critical for continued protection against severe COVID-19. 1/
Researchers examined T-cell responses to SARS-CoV-2 approximately 1.5 years since Omicron first emerged. They find sustained CD4+ & CD8+ spike-specific T-cell memory responses in HCWs, most of whom had received 2 doses of Covid vaccine & had at least one SARS-CoV-2 infection. 1/ Image
Spike-specific T cells were highly cross-reactive with all Omicron variants tested, including BA.2.86.

Abundant non-spike (nucleocapsid and membrane)-specific T cells were detectable in most participants, augmenting the total T-cell resources available for protection. 3/ Image
Read 7 tweets

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