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Kevin McKernan Profile picture
@Kevin_McKernan
Nov 17, 2023 • 8 tweets • 2 min read • Read on X
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More Moderna Patents that speak to the hazard of residual DNA Image
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Irony Image
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Patent Application that emphasizes the risk of Endotoxin contamination Image
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A reminder that this DNA has SV40 origins of replication.

This sequence binds to p53 and heads to the nucleus.

anandamide.substack.com/p/shrodingers-…

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More from @Kevin_McKernan

Kevin McKernan Profile picture
Jan 14
Holy Sh$t
@P_J_Buckhaults just sent me this.

File under: DOES NOT STAY IN THE DELTOID!

nature.com/articles/s4158…Image
Image
@P_J_Buckhaults The reason this is a Holy Sh$t is that the resolution and sensitivity is a game changer.
They dont need to load up 100X the dose to track this. Image
@P_J_Buckhaults Would be nice if they looked at Ovaries/Testes Image
Read 5 tweets
Kevin McKernan Profile picture
Jan 10
Ivermectin and SV40. Image
pmc.ncbi.nlm.nih.gov/articles/PMC74…Image
Read 5 tweets
Kevin McKernan Profile picture
Jan 3
🔥My Review of the Recent FDA-Student DNA contamination Paper.🔥 Image
6-470X the limit but this higher limit is from UV spec which is likely inflating the signal Image
The Qubit data did not run DNaseI standards.
This leads to under reporting the DNA 70%.
Georgiou et al. Image
Read 6 tweets
Kevin McKernan Profile picture
Dec 30, 2024
@blind_nut @DopplerEffect93 @TheStockRizzer @Crash_the_Flash @Double_Christ @MdBreathe Matthew is too incompetent to map reads.
If he could map reads he’d realize Chakraborty doesn’t need peer review because he is using data from 2 peer reviewed papers.
Doah.

anandamide.substack.com/p/chakraborty-…
@blind_nut @DopplerEffect93 @TheStockRizzer @Crash_the_Flash @Double_Christ @MdBreathe DNA doesn’t need to get into the nucleus to cause problems.
But it does. Image
@blind_nut @DopplerEffect93 @TheStockRizzer @Crash_the_Flash @Double_Christ @MdBreathe It binds to P53
Drayman et al Image
Read 4 tweets
Kevin McKernan Profile picture
Dec 11, 2024
Have a look at this. Image
Globin depletion will suppress the BNT162b2 signal. It has a known Beta Globin 5' UTR Image
researchgate.net/publication/35…Image
Read 5 tweets
Kevin McKernan Profile picture
Dec 4, 2024
This is a dense read but it will help you to understand why the DNA fluorometer data is lighting up so much on modRNA. This is much more cross-talk than you see with traditional ssRNA.
That is because these are intercalating dyes that bind to minor grooves are only found in double stranded nucleic acids.
The fact that RNaseA is showing such a reduction in signal is because the RNA isnt single stranded.
At least half of it is digestable by a dsRNA specific nuclease known as RNaseIII.
Another portion responds to RNaseH which only digests RNA in RNA:DNA hybrids.
The fraction that responds to RNAseIII should worry you. Your cells have RNaseIII and its the start of the RNA interference pathway.
To make matters worse, Pharma is using an ELISA that is blind to dsRNA <400bp. It cant see this problem. And they know it exists
Read 7 tweets

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