Why can you still smell things wearing an effective mask?
You can smell nasty things like smoke and rotten eggs even with fit tested #N95 respirators which block tiny viruses/bacteria because the smell molecules have atomic masses that are 17 million times less than a virus.🧵1/
This long thread (with info from @Wikisteff) explains how molecules detected in our olfactory receptors as #smells can pass through material in #masks, #respirators, and #filters (HEPA/MERV-13/CR Boxes) while still blocking tiny particles like #viruses and #particulate matter. 2/
An unrolled one-page web view for this long thread that may be easier to read or share can be found here ( ). 3/
First, some background information. A dalton (Da) or unified atomic mass unit (u) is commonly used in physics and chemistry to express the mass of atomic-scale objects such as atoms, molecules, and elementary particles ( ). 4/en.wikipedia.org/wiki/Dalton_(u…
Oxygen (O2) that we breathe is 32 Da and carbon dioxide (CO2) that we exhale is 44 Da. Other gases that we smell like hydrogen sulfide (H2S) which smells like rotten eggs is only 34 Da, and sulfur dioxide (SO2) the burning smell after lighting a match is 64 Da. 5/
When you pass gas (fart) the smell comes from a multitude of molecules including:
- Hydrogen Sulfide (H2S) = 34 Da
- Methanethiol (CH3SH)= 48 Da
- Dimethyl Sulfide (CH3)2S = 62 Da
- Indole (C8H7N) = 117 Da
- Skatole (C9H9N) = 131 Da
6/
This is very important to understand because by comparison, a single COVID-19 virus particle (virion) has a mass of 602,217,364 Da or 17 million times more than the rotten egg smelling hydrogen sulfide at 34 Da ( ). 7/pnas.org/doi/10.1073/pn…
It is estimated that a COVID-19 infected person carries between 1 billion and 100 billion virions during peak infection ( ). 8/pnas.org/doi/10.1073/pn…
Viruses don't travel on their own through the air, they actually catch rides in aerosols which also contain water, mucins from the lining of the lungs, deep lung fluid and surfactants to make up the complex blob you see in the image ( ). 9/
Multiple studies have found the highest concentration of virus in aerosol particles are in the smaller size ranges which can stay in the air for extended periods of time and lowest concentration in larger droplets that fall to the ground quickly. 10/
COVID-19 was detected in aerosol particles ranging in size from 0.34 micrometers (um) to larger than 8.1 um with the highest concentrations found in particle sizes ranging from 0.94 um, to 28.8 um ( ). 11/tandfonline.com/doi/full/10.10…
@Wikisteff estimates the molecular mass of a 0.8 um largely water based aerosol (which is at the smaller end of the aerosol size spectrum but with highest concentrations of COVID-19 virus) would be approximately 160,000,000,000 (160 billion) Da ( ). 12/ncbi.nlm.nih.gov/pmc/articles/P…
You can see from the graph there is a monstrous difference in mass between gases you can smell like hydrogen sulfide (34 Da) and the bare COVID-19 virus (602 million Da) and the aerosols that COVID virus are transported in (160 billion Da). 13/
Note the graph is in logarithmic scale so each number on the vertical axis scale is 100x larger than the one below. 14/
We know that people can still breathe while wearing masks and respirators so oxygen (32 Da) and carbon dioxide (44 Da) can pass through the filtering material easily which have similar atomic mass to the smell gases (34 to 131 Da) which can also pass through. 15/
In order for a respirator to be effective at blocking viruses and particulate matter it needs to block particles that are 17 million times larger mass than gas to stop a COVID-19 virus and 4.7 billion times larger mass to stop an aerosol that the virus would be travelling in. 16/
So now you know that smelly gases have a similar mass to oxygen and why they can easily pass through mask/respirator material just like oxygen but can N95 respirators actually filter these million and billion times larger mass particles of viruses and bacteria? Yes! 17/
Scientists and engineers who designed these respirators did actually test them to ensure they did filter viruses and bacteria and even came up with standards for determining the efficiency with real viruses and bacteria. H/T: @ghhughes 18/
Bacterial filtration efficiency (BFE) is tested using the ASTM F2101 standard and multiple tests were conducted in this study using the S. aureus bacteria... 19/
while viral filtration efficiency (VFE) was tested using the single-stranded DNA virus bacteriophage phiX174 ( ). 20/ncbi.nlm.nih.gov/pmc/articles/P…
The study found that the N95 respirators they tested filtered more than 99.62% of the bacteria and more than 99.8% of the virus which is much higher than the required 95% filtration needed by the N95 standard to pass. 21/
So there you have it, N95 respirators can actually filter viruses and bacteria and are actually tested with a standard to ensure so. 22/
To learn more about how N95 respirators and HEPA/HVAC filters can filter out such small particles like virus aerosols and particulate matter from smoke (does not work like a sieve), see this thread which explains the physics ( ). 23/
Ok so we have now confirmed the filtering material itself can filter viruses and bacteria, but what about a respirator on the face of a real person in the real world, does that still work? 24/
Thankfully engineers have also built equipment called a condensation particle counter (CPC) to measure the particles both outside and inside a respirator simultaneously. 25/
This testing occurs while the person is wearing the respirator so they can measure exactly how well the respirator is filtering on your face in the real world. 26/
Some of you may have already experienced this through a respirator fit test. You can learn more about how quantitative fit testing with CPC equipment is done in this thread ( ). 27/
As @ghhughes points out, CPC fit testing equipment can measure particle sizes all the way down to 0.02 um in size, much smaller than the COVID-19 virus on its own and the even larger aerosols the virus travels in. 28/
This also demonstrates that N95 respirators can be tested and shown to filter out tiny 0.07 um size particles the size of individual viruses with good fitting N95s measuring less than 0.5% total inward leakage of particles down to 0.02 um. 29/
Since the CPC is testing the level of particles inside the mask while being worn, the results also take into account any gaps around the mask that might be leaking particles in without being filtered ( ). 30/
The most important factor is how well a respirator fits on your face so there is minimal leakage around gaps as some respirators fit people very well and others very poorly. Click "Show replies" 👇 to continue. 31/
You can learn about my fit testing adventure where I found one mask leaked 70x more than another on my face ( ). 32/
The respirator that fit me best was measured to only have 0.2% leakage on my face so filtering 99.8% of particles but when the major wildfire smoke events were happening this summer I could still smell the smoke outside. 33/
Recall that the smoke gas molecules you can smell are billions of times less mass than the smoke particulate matter so while the N95 respirator is filtering out those toxic PM particles. 34/
N95s are not designed to filter out gases so you can still smell and are being exposed to any toxic gases that are in the air. For that kind of protection you need elastomeric respirators with gas filtering cartridges specifically designed for those gases. 35/
What about HVAC, HEPA, and CR box filtration, do they work to filter viruses from the air as well? Yes! The Environmental Protection Agency (EPA) recently conducted some tests with CR boxes which use MERV-13 HVAC filters ( ). 36/s.uconn.edu/EPAresults
The EPA aerosolized non-pathogenic virus (bacteriophage MS2) and measured particle size (0.01 um to 0.6 um) and concentration during the testing in a 3000 square foot test chamber. 37/
They found the virus particle concentration was reduced by 40% after 15 minutes, 97% after 30 minutes, 99.4% after 60 minutes and 99.8% after 90 minutes. 38/
More details about this EPA CR box testing project are described here ( ). 39/
Just like we expect to have access to clean drinking water, we should be demanding that our governments also provide access to clean air. Recently 60-Minutes did an episode on The Air We Breathe which can be seen here ( ). 40/cbsnews.com/video/indoor-a…
Everyone should be aware of the importance of indoor air quality, find out more here ( ). 41/
It is important to note that masks can also reduce some smells and block others all together, it all depends on how the smell molecules arrive; if they are tiny gases on their own or if they are larger particles that get filtered. 43/
I forgot to highlight that N95 filtering material has the hardest time with 0.3 um particle size but actually does better with smaller and larger particle sizes as shown here ( ). Thanks @ToshiAkima. 44/
Arg, I added an extra 0 in the graph for the atomic mass of the COVID virus. The text is correct at 602 million Da, but here is the corrected chart.
Arg, I added an extra 0 in the graph for the atomic mass of the COVID virus. The text is correct at 602 million Da, but here is the corrected chart. 46/
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What do the variant designations like KP.3.1.1 mean and how does it compare to JN.1? How important is just 1 mutation? Can 1 mutation potentially affect our immunity and how vaccines are designed? Read on to find out more. @paulseaman31 🧵1/
You have probably seen people refer to COVID-19 variants with specific codes containing both letters and numbers like JN.1 or XBB.1.5, but what does that mean? 3/
COVID-19 #Wastewater levels in #Ottawa are up again with the circulation of a new KP.3.1.1 DeFLuQE variant ( ). Wastewater is still being updated but on a weekly basis now. 🧵1/3 covid.gilchrist.ca/Ottawa.html
New hospitalizations in Ottawa *due* to COVID-19, Flu or RSV are unfortunately increasing again. There were two big spikes over the past month ( ). 2/3 ottawapublichealth.ca/en/reports-res…
One virus is causing a lot more hospitalizations than the other two over the past year. Even at the lowest point at the end of March 2024, COVID-19 still accounted for more than 40% of hospitalizations between the three viruses and more than 80% for almost half the year. 3/3
#Variant update for #Ontario, #Canada (to Aug 13, 2024)
Today's variant show is brought to you by the letters KP... Looks like KP.3.1.1 has really taken off and separated from the pack at 40% prevalence in Ontario. Graph tools by @Mike_Honey_ 🧵1/
KP.3.1.1 has the #FLuQE mutations and also a key point in the spike protein deleted which gives it much more immune evasion than other variants. 2/
Testing with a recently released monoclonal antibody treatment (pemivibart) found that while it neutralized JN.1 and KP.2 with similar performance... ( ). 3/biorxiv.org/content/10.110…
It seems Canada has not ordered any Novavax JN.1 vaccine doses for the fall which means this protein based vaccine option may not be available to anyone who wants or needs it. We are hoping you can help us change that. 🧵1/
A group of concerned stakeholders advocating for broader access to diverse COVID-19 vaccine options for Canadians, particularly those beyond the mRNA vaccines currently dominating the public offering wrote a letter to the Public Health Agency of Canada (PHAC)... 2/
...all the provinces/territories and immunization providers to address the pressing need for enhanced COVID-19 awareness and education, increased availability and access to protein-based vaccines, such as Novavax, which are currently limited in distribution. 3/
Novavax revealed they had selected the original JN.1 variant as their fall booster and recently released neutralization results on non-human primates (Macaques) including a more recent KP.2 FLiRT variant. 🧵1/
Recall that the JN.1 variant became dominant in many parts of the world in December 2023 so by the time the fall 2024 vaccine program rolls out it will be almost a year old. 2/
Lets look more closely at the neutralization results that Novavax did provide in slide 14 of their investor presentation on May 10th ( ). 3/novavax.widen.net/s/gvwfqkhbhm/2…
With wildfire smoke season here, we all need to think about air quality inside where we spend most of our time. This thread provides multiple examples measuring the air quality inside my home from wildfire smoke and cooking. 🧵1/
People now spend the vast majority of the time indoors. Adults in the USA with a 79 year life expectancy will spend on average 69 years inside of buildings and 54 of those years inside their own homes/residences ( ). 3/nap.nationalacademies.org/catalog/27341/…