Patrick Hsu Profile picture
Nov 24 4 tweets 2 min read Twitter logo Read on Twitter
🧵 of insanely overlooked places to eat in SF:

yongzi ji for amazingly authentic HK-style wonton noodle soup. less than 10 things on the menu so you know it’s good. a hole in the wall run by an impossibly sweet older couple

pro-tip: add ~3:1 vinegar:soy sauce to taste Image
saap ver (“damn good” in Thai) is the best Thai place in the city. the ambiance is boisterous while the food comes correct: an “asian spicy” order puts you straight into a fragrant hot ones episode

don’t sleep on the green beans and tofu or crispy basil duck (or pork belly) Image
Food is my core competency so I will periodically add to this thread over time. I love ernest, san ho wan, flour and water, benu etc. too but I want to highlight the places you’re less likely to find via yelp or google maps. (think Q* search vs only next token prediction 😂)
chuy’s fiesta has the worst storefront and, bafflingly, makes you journey through the kitchen to get to their outdoor patio

they serve you this whipped guac salsa in a molcajete that I slather onto my highly perfected order: a dank quesabirria, vampiro, and al pastor taco Image

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More from @pdhsu

Dec 15, 2021
Delighted to announce the Arc Institute @arcinstitute, a new, independent scientific institution dedicated to the study of complex human disease. Working with our partners @UCBerkeley @Stanford @UCSF, our mission is to accelerate progress in biomedical research and therapeutics.
Learn more about Arc's headquarters, Core Investigators, Technology Centers, Translation Program, and more in this blog post written with my co-founders @SKonermann and @PatrickC: arcinstitute.org/blog/introduci…
@arcinstitute's donors will contribute more than $650M to fund Arc investigators and their labs with complete freedom to pursue curiosity-driven research agendas. Our PIs may hold faculty positions @Stanford @UCBerkeley @UCSF, whose PhD students can also train in Arc labs.
Read 11 tweets
Apr 7, 2020
The best coronavirus/SARS-CoV-2 biology lecture I have seen so far, by Britt Glaunsinger @UCBerkeley @berkeleyMCB @HHMINEWS @igisci. Covers where it comes from, how it gets into the cell, replicates in the host, and exploits the immune system against you.

An exonuclease (ExoN) is encoded in coronaviruses to enable their super large (30 kb) genomes. ExoN protects CoVs from inhibition by nucleoside analogs (e.g. Remdesivir @GileadSciences), suggesting a combo treatment w/ Remdesivir and an ExoN inhibitor could be effective
CoVs form these insane looking replication-transcription complexes in the host cell that are protected by double membrane vesicles. This shields the replicating virus from antiviral that could damage it and concentrates its transcriptional machinery so it can grow faster
Read 5 tweets
Apr 1, 2020
German study on viral load kinetics and seroconversion timescale, out in @nature. Highlights huge time sensitivity of swab testing, viral loads in upper respiratory tract tank after ~5 days of symptoms (swabs are yellow line, orange is sputum).
Link to study, sorry: nature.com/articles/s4158…

Seroconversion is also slow! Only 50% after 7 days. This is important for applications of commercially available rapid serology tests, e.g. for back to work programs.
Lots of interesting data here. Viral sequencing indicates distinct genotypes in throat and sputum, indicating active viral replication in throat. Importantly, this study does not observe severe cases. This is a strength IMO, most papers have studied blazing hot patients
Read 4 tweets

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