Emmanuel Profile picture
Nov 25, 2023 14 tweets 5 min read Read on X
The "devil's pact" between the VIRUS and the ASYMPTOMATICS !

In an exciting study, researchers have shown, how human behavior can change the evolution of the virus. Image
2) When the virus evolved from the Wuhan strain to the Delta, due to the measures to limit its transmission, the virus adapted and evolved, by multiplying by 5 the maximum viral load and by 1.5 in the nb of days before the viral load peaks. Image
3) When Omicron appeared, researchers discovered that BA.1 showed an earlier peak time and shorter viral shedding compared with the pre-Alpha and Alpha variants (Fig. 4b, c). Image
4) The reduction of the incubation period, from 6.65 days for the pre-Alpha, 5.00 days for the Alpha, 4.50 days for the Beta, 4.41 days for the Delta, and 3.42 days for the Omicron variants, generated more asymptomatics. Image
5) From the perspective of virus evolution, which maximizes the basic/effective reproduction number, the evolution of a higher proportion of asymptomatic infection is always favored, because transmissions are not limited, when those infected individuals are not isolated. Image
6) More asymptomatics, and therefore even fewer measures to limit the spread of the virus, which could thus spread almost "invisibly", in as many hosts as possible.
A pact with this evil virus, where the losers are humans.

Thanks for reading 🙏 Image
7) Reference


FYI
@DavidJoffe @RadCentrism @UseBy2022 @RaffyFlynnArt
@RealCheckMarker @RolandBakerIII @arijitchakrav @white_bite @AltenbergLee @xabitron1
@Rrenzokutai @triangle24
@gianlucac1 @siamosolocani
@crwequine @kasza_leslie @outbreakupdates nature.com/articles/s4146…
Image
@DavidJoffe @RadCentrism @UseBy2022 @RaffyFlynnArt @RealCheckMarker @RolandBakerIII @arijitchakrav @white_bite @AltenbergLee @xabitron1 @Rrenzokutai @triangle24 @gianlucac1 @siamosolocani @crwequine @kasza_leslie @outbreakupdates @NjbBari3 @MeetJess @LauraMiers
@DavidJoffe @RadCentrism @UseBy2022 @RealCheckMarker @RolandBakerIII @arijitchakrav @white_bite @AltenbergLee @xabitron1 @triangle24 @gianlucac1 @siamosolocani @crwequine @kasza_leslie @outbreakupdates @NjbBari3 @MeetJess @LauraMiers JN.1 WAVES with HIGH VIRAL PEAKS in wastewater data
(Part 2) Image
@DavidJoffe @RadCentrism @UseBy2022 @RealCheckMarker @RolandBakerIII @arijitchakrav @white_bite @AltenbergLee @xabitron1 @triangle24 @gianlucac1 @siamosolocani @crwequine @kasza_leslie @outbreakupdates @NjbBari3 @MeetJess @LauraMiers 8) In previous tweets we explained that the characteristics of Omicrons were: 
- a viral load which arrives earlier and lasts less time 
- an increase in asymptomatics
Virus transmission occurs from an infected individual to susceptible individuals Image
@DavidJoffe @RadCentrism @UseBy2022 @RealCheckMarker @RolandBakerIII @arijitchakrav @white_bite @AltenbergLee @xabitron1 @triangle24 @gianlucac1 @siamosolocani @crwequine @kasza_leslie @outbreakupdates @NjbBari3 @MeetJess @LauraMiers 9) ...depending on the infected individual’s infectivity, which depends on their viral load.
Why, if the viral load is lower per individual, are we seeing such viral peaks? To understand this, we need to go back to the transmission potential RTP Image
@DavidJoffe @RadCentrism @UseBy2022 @RealCheckMarker @RolandBakerIII @arijitchakrav @white_bite @AltenbergLee @xabitron1 @triangle24 @gianlucac1 @siamosolocani @crwequine @kasza_leslie @outbreakupdates @NjbBari3 @MeetJess @LauraMiers 10) ...which is calculated from the sum of newly infected individuals [number of contacted individuals per day] × [transmission probability per contacted individual]).
The paradox is that the more asymptomatic people you have (who contaminate without knowing it), Image
@DavidJoffe @RadCentrism @UseBy2022 @RealCheckMarker @RolandBakerIII @arijitchakrav @white_bite @AltenbergLee @xabitron1 @triangle24 @gianlucac1 @siamosolocani @crwequine @kasza_leslie @outbreakupdates @NjbBari3 @MeetJess @LauraMiers 11) ... the faster the transmission, especially if the peak occurs earlier.
And this, even if the viral peak per individual is lower than in the pre-alpha variants.
JN.1 characterizes an evolution of a “stealth” phenotype showing a decreased peak viral load per individual Image
@DavidJoffe @RadCentrism @UseBy2022 @RealCheckMarker @RolandBakerIII @arijitchakrav @white_bite @AltenbergLee @xabitron1 @triangle24 @gianlucac1 @siamosolocani @crwequine @kasza_leslie @outbreakupdates @NjbBari3 @MeetJess @LauraMiers 12) ...with a high proportion of asymptomatic infection.
We are therefore witnessing a decoupling between the evolution of virus phenotype and the evolution of clinical phenotype.

Thanks for reading 🙏 Image

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More from @ejustin46

Mar 2
Catching COVID-19 in Buildings: Combining Wastewater, Air, and Surface Monitoring !

An amazing study in Nature.
H/t @mryoung151
nature.com/articles/s4137…Image
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They placed air samplers in the lobby of a dorm where students with COVID-19 were isolating. Image
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The researchers also collected air samples from the building's rooftop exhaust, swabbed high-touch surfaces, and tested the building's wastewater. Image
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H/t @florian_krammer Thanks @DavidJoffe64
journals.asm.org/doi/10.1128/mb…Image
2) The H5N1 bird flu virus has been spreading rapidly since 2020. An important change is that the neuraminidase (NA) protein on this virus now has a longer "stalk" region.

In the past, most H5N1 viruses had a shorter NA stalk. Image
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Feb 24
What an UNFORTUNATE CHOICE of WORD it is to REFER to the term “VARIANT” in relation to SARS-CoV-2.

No one would think to call Prince William a "variant" or a mere variation of Queen Elizabeth; he shares the same family and lineage. That's all. Image
2) I wanted to use this analogy to highlight the significant differences in pathogenicity and transmission among the Alpha, Delta, and Omicron variants, as demonstrated by a recent study published in Nature.
nature.com/articles/s4429…Image
3) By suggesting that the various lineages of SARS-CoV-2 consist of only minor mutations in the Spike protein—while overlooking the other proteins—and by using the term "soup of variants," which I consistently contest, we diminish the profound changes ... Image
Read 5 tweets
Feb 24
Can a SYNTHETIC RECEPTOR that BINDS to the SUGAR (Glycans) on the SARS-CoV-2 Spike Protein, PREVENT the VIRUS from INFECTING Human CELLS?

Amazing study 🙏 @DavidJoffe64
…mistry-europe.onlinelibrary.wiley.com/doi/10.1002/cb…Image
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Read 6 tweets
Feb 23
WHEN and WHERE was the H5N1 influenza A virus (genotype D1.1) DISCOVERED ?

A very interesting article from
@LouiseHMoncla @angie_rasmussen @MichaelWorobey @PeacockFlu and colleagues
virological.org/t/timing-and-m…Image
2) The H5N1 influenza A virus (genotype D1.1) was discovered in dairy cattle in Churchill County, Nevada, on January 31, 2025. The detection followed a routine surveillance program, where bulk milk samples were collected from dairy processing plant silos on January 6 and 7, 2025. Image
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Investigations revealed that the virus likely jumped from birds to cattle sometime between late October 2024 and early January 2025 ... Image
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What makes VIRUSES like Herpes, Epstein-Barr, Flu, H1N1, H5N1 and HIV so EFFECTIVE at INFECTING the BRAIN ?

Viruses can infect and damage the brain, leading to conditions like Alzheimer's, Parkinson's, schizophrenia, and depression
link.springer.com/article/10.100…
2) Some Viruses are able to successfully infect the brain for a few key reasons:

▶️ Direct Brain Entry: Some viruses can directly enter the brain through the nose or other pathways, allowing them to directly infect brain cells. Image
3) ▶️ Evading Immunity: Certain viruses can hide from or suppress the immune system, enabling them to persist in the brain undetected.

▶️ Breaching the Blood-Brain Barrier: Viruses can damage the protective barrier between the brain and bloodstream ...
Read 6 tweets

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