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Emmanuel Profile picture
@ejustin46
Nov 26 • 11 tweets • 4 min read Twitter logo Read on Twitter
EFFECTIVENESS of TESTS 🤔

This mega-thread is an attempt to respond to the request of certain followers.
It was difficult to find interesting studies, due to the abandonment of testing policies, with the sole aim of covering up the pandemic. Image
2) One of the most interesting study :

"Testing at scale during the COVID-19 pandemic"

"Even the most extensive testing schemes have been found to miss many infectious individuals and to provide only partial population coverage." nature.com/articles/s4157…
Image
3) "The rapid infectious course of SARS-CoV-2 and the possibility of its transmission by presymptomatic or asymptomatic individuals blunts the impact of population-scale testing, as many infectious individuals escape detection" Image
4) "Comparison of Rapid and Automated Antigen Detection Tests for the Diagnosis of SARS-CoV-2 Infection"
mdpi.com/2075-4418/12/1…
Image
5) An interesting meta-review

"Use of Rapid Antigen Tests during the Omicron Wave - Ontario COVID"
covid19-sciencetable.ca/sciencebrief/u…
Image
6) Virus in feces, even when tests are negative
7) Home COVID tests lead to vast undercount of cases
8) COVID-19 test allocation strategy to mitigate SARS-COV-2 Infections across school districts
9) Saliva test effectiveness
10) Testing instead of quarantine ?
11) And to end on a nice note, the use of dogs to test.

Thanks for reading 🙏

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More from @ejustin46

Emmanuel Profile picture
Nov 28
COVID-19: LONG-TERM DAMAGE to IMMUNE SYSTEM

When we have to read studies between the lines... Image
2) We posted a first study few weeks ago about how inflammation can trigger lasting phenotypes in immune and non-immune cells.
This article of NIH proposes a short but clear summary.
covid19.nih.gov/news-and-stori…
Image
3) "Researchers found that severe COVID-19 could cause lasting changes in stem cell gene expression that made the immune system produce more white blood cells"
Reference of this first study :
Read 7 tweets
Emmanuel Profile picture
Nov 27
COVID-19 and the ACCUMULATION of so-called SENESCENTS cells ("ZOMBIE" cells) 😨

2 recent studies shed interesting light on this subject.

Fig. Immunosenescence and inflammaging : partners in the COVID-19 crime Image
2) In humans, viral replication and pathology increase with age.
“We found Covid-19 accelerates the presence of ‘zombie’ or senescent cells, which accumulate naturally and gradually in the brain as we get older,” found researchers. Image
3) 1st STUDY :
"Removal of senescent cells reduces the viral load and attenuates pulmonary and systemic inflammation in SARS-CoV-2-infected, aged hamsters"
nature.com/articles/s4358…
Image
Read 10 tweets
Emmanuel Profile picture
Nov 26
How COVID-19 triggers MASSIVE INFLAMMATION and COVID blood shows signs of PYROPTOSIS ! Image
2) Before presenting a study, and explaining what pyroptosis is, we recommend this very interesting article, from which we borrowed the title.

“About 6 percent of the blood monocytes in the infected patients were dying an inflammatory death,” answers.childrenshospital.org/covid-19-infla…
Image
3) The study :
"FcγR-mediated SARS-CoV-2 infection of monocytes activates inflammation"

First a short explanation on pyroptosis (for layman) :
Pyroptosis is a highly inflammatory form of cell death that leads to the release of pro-inflammatory cytokines nature.com/articles/s4158…
Image
Read 7 tweets
Emmanuel Profile picture
Nov 26
SARS-CoV-2 viral PERSISTENCE in lung alveolar MACROPHAGES is controlled by IFN-γ and NK cells

"Our findings reveal an interplay between NK cells and macrophages that regulated SARS-CoV-2 persistence in macrophages and was mediated by IFN-γ" nature.com/articles/s4159…
Image
2) Fig. 2: SARS-CoV-2 is expressed in BALF Mac (Bronchioalveolar lavage Macrophages) from WTM and OM at more than 221 d p.i. Image
3) Fig. 3: SARS-CoV-2 replication in Mac in vitro alters Mac transcriptomic profile. Image
Read 10 tweets
Emmanuel Profile picture
Nov 26
KEY STUDY from @VirusesImmunity

DISTINGUISHING FEATURES of long COVID identified through IMMUNE PROFILING

Fig. 1: Demographic and clinical stratification of participants with LC. nature.com/articles/s4158…
Image
2) Fig. 2: Exaggerated SARS-CoV-2-specific humoral responses and altered circulating immune mediators among participants with LC. Image
3) Fig. 3: Participants with LC showed limited but selective autoantibodies against the human exoproteome. Image
Read 8 tweets
Emmanuel Profile picture
Nov 25
The "devil's pact" between the VIRUS and the ASYMPTOMATICS !

In an exciting study, researchers have shown, how human behavior can change the evolution of the virus. Image
2) When the virus evolved from the Wuhan strain to the Delta, due to the measures to limit its transmission, the virus adapted and evolved, by multiplying by 5 the maximum viral load and by 1.5 in the nb of days before the viral load peaks. Image
3) When Omicron appeared, researchers discovered that BA.1 showed an earlier peak time and shorter viral shedding compared with the pre-Alpha and Alpha variants (Fig. 4b, c). Image
Read 8 tweets

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