Christie Laura Grace Profile picture
Dec 4, 2023 26 tweets 7 min read Read on X
1/ 🚨🧵
RAPID AAD-Aortic Aneurysm and Dissection (tearing/rupture) is lethal.
Plasmid DNA is dsDNA.
dsDNA can enter cells from the body's own sources, or a contamination event (💉)
dsDNA is shown to cause AAD via the STING path.
A thread on a study, and adverse event cases.
Image
2/ The study:
Critical Role of Cytosolic DNA and Its Sensing Adaptor STING in Aortic Degeneration, Dissection, and Rupture

. 2020;141:42–66
doi.org/10.1161/CIRCUL…
ahajournals.org/doi/10.1161/CI…
Image
3/ AAD is an extremely lethal cardiovascular event.
The STING pathway is implicated in tissue destruction and inflammation in numerous conditions and diseases.
The study done in vivo, saw the presence of dsDNA, and tracked STING activation in animal/human models in AAD.
4/ Specifically, cytosolic (outside of nucleus, but still in the cell) DNA and STING pathway activation occurred, in combination with macrophages.
The presence of cytosolic DNA in aortic tissues from patients with sporadic ascending thoracic AAD, showed immune system activation,
5/ as a response to dsDNA that should not be there. In patients w/ AAD, cytosolic dsDNA and STING pathway activation were detected in specific cell types, like smooth muscle cells in aortic tissues.
Smooth muscle cells impact the structural integrity of the aortic wall. Image
6/ Order of operations:
Presence of exogenous dsDNA in aortic tissues, from sources such as damaged nuclei, mitochondria (or 🧬💉contamination?) is recognized by cellular "sensors" called the STING pathway. The STING pathway then activates the immune system as a response to the
7/ presence of genetic material that should not be floating around in the cytoplasm. This can occur all over the body, but right now we are focusing on rapid onset lethal aortic dissection. Immune system activation leads to the presence of interferons and macrophages.
8/ because the STING pathway is activated, a rapid inflammatory response and condition occurs, and in this case, it is happening in the heart, in the aorta. Macrophages are "activated" and rush to the area.
This starts a cascade of really bad stuff. The smooth muscle cells
9/ inside the wall of the aorta in the heart, then release THEIR OWN dsDNA as a response to being inflamed. This is a direct result of inflammation and damage being done by the immune attack on the body's own aorta and heart.
Macrophages then "engulf" the dsDNA that is
10/ getting kicked out of the smooth muscle cells, which is different dsDNA than the dsDNA which kicked off this whole domino effect.
Then subsequent activation of STING pathway in macrophages contributes to downstream effects, including MMP-9 production and extracellular matrix
11/ (ECM) degradation.
Note: MMP-9 is an enzyme that plays a role in the degradation of extracellular matrix (ECM), which is a part of tissues that provides structural support.
The production of MMP-9 by macrophages contributes to the degradation of the ECM, thus remodeling and
12/ dissection of the aorta. This sequence drives AAD.
This includes smooth muscle cell (SMC) injury, inflammation, and ECM degradation--causing a lethal situation.
13/ just to be clear, the initial activation of STING before smooth muscle cell involvement with that area releasing it's OWN dsDNA are two separate parts of the domino of events, the cascade that kicks off this entire mechanisms. It can and does occur in people without
14/ an external dna contamination event.
However, exogenous dsDNA entering cells in the heart, should plausibly activate this same pathway.
In order for the heart, and the cardiomyocyte to be "transfected", a lipid nanoparticle would have to have a molar ratio of 10:1, that is
15/ 10:1 ratio of ionizable lipids to dsDNA plasmid contamination combined with modRNA to enter the area of that heart, especially the cardiomyocyte.

"Ionizable Lipid Nanoparticle-Mediated Delivery of Plasmid DNA in Cardiomyocytes"

dovepress.com/ionizable-lipi…
Image
16/ a concern would be, if this occurred after vaccination, and if an LNP was loaded with dsDNA and made its way to the heart, the cardiomyocyte, and namely, the aorta.
17/ An autopsy case report of aortic dissection after mRNA COVID-19 vaccination: correspondence



Leg Med (Tokyo). 2023 Feb; 60: 102169.
Published online 2022 Oct 26. doi: 10.1016/j.legalmed.2022.102169 ncbi.nlm.nih.gov/pmc/articles/P…
Image
18/ An autopsy case report of aortic dissection complicated with histiolymphocytic pericarditis and aortic inflammation after mRNA COVID-19 vaccination
DOI: 10.1016/j.legalmed.2022.102154

pubmed.ncbi.nlm.nih.gov/36191411/
Image
19/ Myopericarditis and Acute Aortic Dissection after Receiving mRNA Based COVID 19 Vaccine: Cases Report and Literature Reviewed - รายงานผู้ป่วยที่เกิดกล้ามเนื้อหัวใจอักเสบและ ผนังหลอดเลือดแดงใหญ่ปริภายหลังได้รับ mRNA based COVID-19 วัคซีน และการทบทวนวารสารฯ
21/ “Spontaneous” Coronary Artery Dissection After SARS-CoV-2 Messenger RNA Vaccination



DOI: jscai.org/article/S2772-…
doi.org/10.1016/j.jsca…
Image
22/ Could the spike expression be involved too? Sure

Got nucleocapsid?
@P_J_Buckhaults
@DrJBhattacharya
@drdrew
@SenatorRennick
23/ **** note: "Plasmid DNA is dsDNA" refers to the DNA contamination event that everyone is currently speaking to right now. This is speaking to the biotech plasmid that contains the SV40 promoter, the antibiotic resistance, the gene encoding for spike, etc.


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@P_J_Buckhaults
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More from @_HeartofGrace_

Sep 20
1/ 🚨🚨 Varma is Chief Tech/Sci/R&D Officer at SIGA TECH
🚨Detected/Suspected Collaborations w/ Evidence of SIGA TECH:
1. Biomedical Advanced Research and Development Authority (BARDA)
2. U.S. Department of Defense
3. CDC, WHO, NIAID, and academic institutions.

Details (receipts with archives in posts below in the thread):

🚨Biomedical Advanced Research and Development Authority (BARDA)
Approximate dates:
Contracts initiated in 2014, w/ subsequent modifications through 2024 and continuing:
Development and procurement of TPOXX (tecovirimat) for public health preparedness against smallpox and other orthopoxvirus.

🚨U.S. Department of Defense (DoD)
Collaborations began around 2014 and continue to the present. Research and development initiatives focusing on antiviral efficacy against biological agents, "enhancing national security".

🚨Centers for Disease Control and Prevention (CDC)
Ongoing partnerships since at least 2014. Purpose: Public health initiatives aimed at preparedness and response strategies for infectious disease outbreaks, including public awareness regarding antiviral treatments.

World Health Organization (WHO)
🚨Discussions and potential collaborations initiated in 2020.
Addressing global health threats and improving access to antiviral therapies, especially in low-resource settings.

🚨National Institute of Allergy and Infectious Diseases (NIAID)
Collaborative research started around 2016 and is ongoing. Purpose: Joint research projects to develop therapeutics for viral infections and evaluate antiviral compounds.

Academic Institutions (specific collaborations may vary)

(see attached posts for details. these might need editing/updating with more information or corrections)
2./ Jay Kumar Varma
Chief Tech/Sci/R&D Officer at SIGA TECHNOLOGIES, INC.
Net worth: 156 201 $ as of 2024-08-30

Archive: archive.ph/WN41j#selectio…
3/ 🚨🚨Department of Health and Human Services (HHS)
Recipient
SIGA TECHNOLOGIES, INC.
27 E 62ND ST
NEW YORK, NY 10065-8014
UNITED STATES
Congressional District: NY-12

$274.8 Million
Outlayed Amount

$571.3 Million
Obligated Amount

archive.ph/dfs4f#selectio…
Read 13 tweets
Sep 15
1/ 👀🚨⚕️⚕️Happy Sunday! How I sped up the healing of my torn hip that I was told I needed surgical intervention on (I have not had any surgery on it!!!):

I was told I needed medical intervention on my hip after imaging showed tear of the anterosuperior labrum from 12:00 to 3:00, an additional partial tear of the distal left gluteus medius tendon, and suspected occult fracture of the femur.

I do some pretty serious trail running and I jump over downed trees and I go very quickly. I make tracks fast. However I'm getting older and I have EDS confirmed by an actual EDS doctor so I am prone to these injuries. I work out anyways because it is the best protection for someone with EDS. Lift weights and workout. Joint tears are a thing for me--I am no stranger to them, and I HAVE had several joint reconstructions because of sports injuries, but not this time.

I do not drink or do drugs and I have not been one to do those things--I am not in recovery. I have eaten a primary whole food diet since I was a baby. We grew up with gardens and I have continued that. I am a long time martial artist, I have played in sports in school, and I am a distance runner cross-country ultra runner and I am 49 years old. I have to believe this is why I don't have any wrinkles at age 49 even though I only use soap on my face, and why I heal faster even though I can get injured a bit easier.

I've been doing some research on the injection injuries and those with lingering viral symptoms. I've been looking at macrophages and I know our friend doorless carp has too.

Macrophages exist on a spectrum. They are part of your immune system and the cleanup process. There are macrophages called m1 and M2. You have an inflammatory type and an anti-inflammatory type but there are subtypes and they are very adjustable and they are known to have what is called plasticity.

It's not like an on/off switch and I think that's where a lot of people even doctors and scientists will get confused thinking you can just flip things. They can actually exist in both states at the same time and you do not want to have just an entire mess of your macrophages to be in an anti-inflammatory state because you need the ones that attack not just heal. M1 macrophages are pro-inflammatory and M2 are anti-inflammatory.

Knowing that I don't drink soda or juice and I also primarily just drink water, green tea, and black coffee with whole foods mostly I started a couple of supplements that are known to shift macrophages from the pro-inflammatory type that are activated by cytokines to the m 2 type which are anti-inflammatory.

When I went for my initial MRI of my hip I was placed on a stronger MRI machine compared to the regular one people usually go on which is 15 times stronger than a regular MRI. I noticed the next day my hip felt a little better and I wondered why and I thought holy smokes did the strong magnets of the MRI just flip my macrophages (I've been doing other writing on a different paper involving macrophages I also plan to submit to publication).

So I searched journals and I found a study really quickly that shows when mice were subjected to different strengths of MRI they had a strong correlation in their macrophages flipping from the inflammatory type to the anti-inflammatory type and the stronger the MRI the stronger that response was. The researchers also found that the mitochondria shifted in the cells and a few other things happened.

I'm not suggesting anyone do this. This is not medical advice. Always check with your doctor.
So I thought I should do what any smart person would do because the MRI is targeting the area--find a way to get them to do it again!!!!
So I hopped up on that stronger version of the Tesla 3 MRI to get my hip scanned again.

I know that I'm not completely healed but I am now walking faster about 3 to 5 mi a day out hiking now and I know that I'm going to jog very soon.

I'm taking it easy so I don't accidentally re-injure myself.

My doctors are baffled.

I sent them this study in the second tweet.Image
2/ "The Effect of Magnetic Field Gradient and Gadolinium-Based MRI Contrast Agent Dotarem on Mouse Macrophages"

ncbi.nlm.nih.gov/pmc/articles/P…
Image
3/ (I did not have ANY contrast agent. NFW!)
Read 5 tweets
Sep 13
1/ Study: Ivermectin Promotes Peripheral Nerve Regeneration during Wound Healing.
I am uncertain if anyone has spoken about nerve healing with Ivermectin
I wondered if people w/ burning pain were getting better w/ ivermectin because it was healing nerves, not spike related. Image
2/ here is the study and my substack reviewing the study:



pubs.acs.org/doi/10.1021/ac…
christiegrace.substack.com/p/study-iverme…
3/ I’ve heard from several people with modRNA injections and injury that have burning pain who may or may not have a diagnosis of an autoimmune demyelination, small fiber neuropathy, etc. that ivermectin is helping them.
Read 26 tweets
Sep 6
1/ 🚨 👀 This is very concerning and it requires additional posting.

"Right now in the US, Lockheed Martin is close to completing a prototype that will analyze media to “detect and defeat disinformation.”

And by media, those commissioning the tool – called the Semantic Forensics (SemaFor) program – mean everything: news, the internet, and even entertainment media. Text, audio, images, and video that are part of what’s considered “large-scale automated disinformation attacks” are supposed to be detected and labeled as false by the tool."

"The development process is almost over, and the prototype is used by the US Defense Department’s Defense Advanced Research Projects Agency (DARPA)."

Maybe some of you can chime in on the implications of this, if they aren't obvious enough.Image
3/ Image
Read 10 tweets
Sep 2
Timeframe for possible cancer risk (growth formula included at end). We will use calculations AND LOVE CANAL CHEMICAL EXPOSURE example (something I wrote about in undergrad). These are just my concerns. Cancer is not a mathematical calculation, it is exponential when it comes to onset and exposure of populations to a genotoxin.

The cancer experts who have been interviewed SHOULD have told you that. Maybe a cancer expert can chime in (and do not give the "bad luck" hypothesis):

The obvious scenario is a known genotoxic/mutagenic substance was injected into billions of people on the planet, some of them, more than once, and there is serious concern that this known harm can cause genetic instability and worse.

If we do not even look at pseudouridine content in the modified RNA or spike protein, from what I have read and my knowledge working in industry and education is the following:

If we introduced just the linearized DNA plasmid pieces alone inside of a lipid nanoparticle and injected them into people, this will vary depending on how many exposures have occurred--each exposure meaning a single injection (discount RNA or anything else in there--this is just hypothetical for DNA):
Time frames (we are working off March 2021 as that as when general population was getting the first of the "series"):

1. First Window of Time for Cancer Risk: 0-2 Years out from initial exposure
0-2 years out will see the LOWEST number of cancers. We would see acute reactions--the immediate toxicity or inflammation.
Cancer rates should be the lowest during the first two years (that is the time we are now exiting, we are entering the next window of time), but aggressive hematological cancers ( acute leukemias, lymphomas) are the ones that are showing up with pancreatic. However, there are other genetic and environmental factors. We add in spike and pseudouridine, so these timelines might be speeding up. This timeline is just DNA plasmid pieces.
Existing polyps with mutations might show accelerated growth or progression to dysplastic lesions or early-stage cancer during the first two years out. The immediate effects of plasmid-induced genomic instability or inflammation could speed up the malignant transformation. We are primarily speaking to colon polyps, although there are endometrial polyps, etc and those are less likely to turn with a lower incidence.

2. Second window of time is 2. 2 to 5 Years after initial exposure.
DNA plasmids have either caused significant genomic instability through cGAS STING, or other mechanisms, or integration, causing increase in cancer. Chronic hematological cancers and early solid tumors should be appearing. This window would show a peak in cancer development if the genotoxic effects are significant but not immediate, meaning, it took time.

Polyps with pre-existing mutations, if changed by DNA plasmids inside of an LNP, might progress to more advanced stages of cancer, FASTER. We would see progression from polyps to cancerous tumors.

3. Third window of time should be the highest we see, which is within 3. 5 to 10 Years since initial exposure

The largest number of cancers SHOULD be seen during this window of time. Solid tumors in the liver, pancreas, or lungs, and hematological cancers should be exploding now in the rates that will be seen The delayed nature of these cancers reflects the cumulative impact of long-term genomic instability, inflammation, and mutagenesis induced by the DNA plasmids and LNPs.

This is also should be the peak time for poylps now showing cancer progression if exposure to DNA plasmids inside of an LNP were correlated. The largest number of cancers related to mutated polyps might be detected during this period.
Dr. Harvey Risch I believe to be one of the more respectable people who has spoken out, and he has stated at the three year mark is when we should start seeing more. However, that is just the beginning, because we go exponential, not mathematical.

Numbers game/probability:
Cancer numbers should be exponential cancer risk by time frame/windows after first exposure of injection because in biological systems, cancer incidence often shows exponential growth, not linear, due to accumulation of genetic mutations and interactions of multiple factors contributing to tumor progression.

Arbitrary numbers (I am just throwing numbers in here for math's sake so you can see scales of progression) might look like:
Quantification
If we were to model this mathematically:

Linear increase model using arbitrary numbers:
If we observed 5 cancers in the first 3 years, and the incidence rate increases linearly, we might expect an additional 5 cancers in the next 3.5 to 10 years, resulting in a total of 10 cancers.

Cancer rates go exponential:
If the increase is exponential, the number of cancers should grow faster.

Let's take the starting point of five cancers as example. Of COURSE there are other factors like total number of mutations already present, environment, predisposition, female versus male, lifestyle, age, etc, but if cancers double every year, starting from 5 cancers, you could expect a significantly larger number of cancers in the later period.

For example, if the rate of increase is such that the number of cancers doubles every 2 years, then by 7 years (from the initial 3), you could see approximately 40 cancers (based on doubling).

Real Math:
Exponential Growth Formula:

The general formula for exponential growth is:
N9t)=N0​×e(rt)--that is N nought times e and then (rt) is an exponent.

N(t) is the number of cancers at time t
N (0)​ is the initial number of cancers
e is the base of the natural logarithm (approximately 2.71828).
r is the growth rate
t is the time period

Ok, let's go back to the initial which we are saying is five cancers, that is it.

this is the calculation for growth rate, which we do not have at the moment:
Estimate Growth Rate (r): Calculate the growth rate r using:
r=ln(N(t)/N0​)​/t

If we started with five cancers and this is just all arbitrary, we had a growth rate of 0.2 (we do not know what this is!) then we say time is after ten years, we do the math and we land at 37.
N(10)=5×e(0.2×10) N(10)=5×e2N(10) = 5 \times e^{2}N(10)=5×e2 N(10)=5×7.389N(10) = 5 \times 7.389N(10)=5×7.389 (since e2≈7.389e^2 \approx 7.389e2≈7.389) N(10)≈36.945N(10) \approx 36.945N(10)≈36.945

Either way, we do not know the growth rate but we know cancer is exponential process.

Love Canal was a disturbing thing that happened years ago. Love Canal was a neighborhood in Niagara Falls, New York. The Hooker chemical company (this is all off the top of my head) had been dumping chemicals into the ground, buried chemical waste in an abandoned canal. This site was later used for residential development, and they sold the land for a dollar and this land was used to build houses on for families. A woman who was not a scientist by the name of Lois Gibbs did her OWN epidemiological investigation into the miscarriages and cancers that started to pop up in her community that would lead to a government investigation. It was terrible.

In the 1970s, residents reported high rates of cancer, birth defects, and other health problems, which were linked to the buried chemicals leaching into the environment.

In the Love Canal case, exposure to toxic chemicals did not immediately result in a large increase in cancer rates. The effects were observed over several years.

Epidemiological studies found elevated rates of cancer and other health issues among the residents, particularly in the years following their exposure.

In the lipid nanoparticles with the existence of DNA plasmids, where exposure to carcinogens is high and widespread, cancer incidence can increase exponentially. This was injected into billions of people.

Thinking back to those who have given their speeches, I am kind of horrified you did not mention this as cancer experts.

I am kind of alarmed.

I have no idea what the outcomes are going to be but if cancer increases exponentially and if a large portion of the population of the planet was subjected to genotoxic material SIMULTANEOUSLY within similar time frames starting in March of 2021, I cannot say what will happen, but we are now at September 1st of 2024, and I hope this is all incorrect and the people speaking out saying it is nothing or rare are correct.
Read 5 tweets
Aug 28
🚨💉 For those not aware, if you go to Moderna's website that lists their clinical trials, you'll see they are in process of redevelopment of traditional vaccines and changing to RNA based with lipid nanoparticle. It is imperative to place political motivations and others to the side right now and focus on global public health and the ramifications.
Spike protein and DNA plasmid do not have to be present for this platform to cause harm. Those are just additional things which cause harm, and yes they are concerning beyond belief.
You do not need pseudoephedrine despite what anyone says anywhere with any credential to have a frame shift, junk proteins made, or misfolding resulting in aberrant protein creation by the human body by injecting RNA with a lipid. If you look in my highlighted tweets you will see a thread with over 100,000 views which details out a study that was done by Moderna scientists which was paid for by Moderna where they showed the positively charged lipids are binding through a covalent bond to any nucleic acid which they come in contact with.
Inside the lipid nanoparticle that is going to happen with the RNA and it's going to create what is called an adduct.

The fact that no podcaster ever mentioned this besides the ones I have been on despite the fact that I have tagged them all is alarming. Instead politicians and podcasters only focused on the pseudoeuridine, unless I went on that podcast and we had a talk otherwise it has been ignored and I'm pissed and you should be pissed too.
Another conversation to be had is why this is being ignored.

This is alarming. This is alarming on multiple fronts.

The positively charged lipids can also bind with other nucleic acids that have a negative charge. They will form what is called a covalent bond.

This will cause slippage in what is called the ribosome.

It does not matter if it is the spike protein or not. It does not matter if pseudoeuridine is present or not.

Molecular mimicry will also occur. To think this will not happen is outrageous.

Take the number of people who have died, those who have survived who have lasting harms, take the number of pregnant women who suffered, the miscarriages, all of it, and there is the very real potential of taking that number and multiplying it exponentially if all of these come to fruition.

This is not to discount anyone who has already been harmed or died.

The potential for harms are unimaginable.

We also know that the biodistribution impacts pregnant women differently.

We know that 8 times the amount of the lipid nanoparticle goes to the lymphatic system of pregnant women compared to women who are not pregnant who get these injections.

This isn't a mathematical calculation when we speak to risk. This isn't an addition. This isn't a plus or minus numbers game. This is exponential harms.
3/ all RNA inside of a lipid nanoparticle that contains positively charged lipids will create adducts.

This has been studied and proven by moderna scientists and the research is proven in that tweet thread.

Everybody ignored it. All podcasters ignored it. All scientists and doctors and professors ignored it who have gone on podcasts.

I don't have any good words for you anymore.

Read 4 tweets

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