3/ ...during that era, physiologists were focused on cardiac pressure/volume relationships. LVEF emerged as a metric reflecting cardiac volumes, thus filling an unmet need. doi.org/10.1161/01.cir…
4/ Then, #EchoFirst for assessing LVEF then became available. #MAPSE was shown early to correlate with LVEF. However, it was only considered a "quick and dirty" surrogate of LVEF. doi.org/10.1016/S0894-…
5/ The limitations of LVEF then became strikingly obvious, as patients with heart failure but preserved LVEF had similar prognosis as reduced LVEF. (2006)
6/ However, this was also the time when GLS by speckle-tracking #EchoFirst emerged as a metric of LV function.
Speckle-tracking was a huge technological trend, and still is. #MAPSE relies on simple M-mode, lacking the "WOW!"-factor and thus overlooked.doi.org/10.1016/j.echo…
7/ However, GLS relies on software and excellent image quality - two luxuries often absent in #CriticalCare.
#MAPSE is highly feasible in #ICU, shows better prognostic ability that LVEF...
8/ The assumed superiority of GLS was recently challenged. In a head-to-head study using #WhyCMR, MAPSE had better prognostic ability than GLS and LVEF.😎 doi.org/10.1161/JAHA.1…
9/ Finally, because #MAPSE is works even when image quality is poor, it is available for automatic monitoring, especially with TEE. #AutoMAPSE
🧵🔓:
10/ To conclude, #MAPSE is a classical parameter of LV function that has been overshadowed by technological trends. MAPSE is easy to master by anyone doing #POCUS and #EchoFirst.
Imagine how medicine would be different if MAPSE was a standard parameter since 1967?
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1⃣ Can MAPSE redefine "the hyperdynamic heart?
The term "hyperdynamic LV" - EF > 55% - is misleading. It has no relation to a hyperdyanmic circulation; SV/CO. Someone bleeding to death has a hyperdynamic heart, but the circulation is life-threatening hypodynamic.
2/n
MAPSE is cardiac motion, and defining the hyperDYNAMIC heart as good cardiac motion makes perfect sense. Recent geometrical analysis of cardiac pumping shows that MAPSE is the main determinant of SV. Fig from @mugander: tinyurl.com/mxbfmcyk
Why? 3/n