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It's pretty depressing that when I say Novavax creates a mucosal response that folks are still melting down and coming back with "Novavax is not sterilizing" while calling it misinformation.
@Friesein and I talked about it a while ago and I've been slowly phasing out the term "sterilizing" and instead refer to it as the mucosal response... because the mucosal response is well documented and it's essentially the same thing...
But the debate about what sterilizing means when you use that word is a bit more complicated and controversial.
Keep in mind, I say mucosal and they respond with sterilizing which already is very confusing...
But this means they know that mucosal means sterilizing but they doubt the science behind it without even looking at it, muddying up the explanation in the process and that confuses folks further.
So, let's break it down.
Novavax creates a mucosal response mRNA does not and this is well documented. This response is considered sterilizing but saying sterilizing does not traditionally mean it 100% blocks infection, even to what extent Novavax does this is unclear...
It's a difficult thing to measure in real terms.
This misplaced definition of sterilizing is actually an old antivaxxer trope that has slowly made it's way mainstream that argues that all vaccines are ineffective because of this.
These tropes are being repeated by mRNA advocates playing expert on the internet, when they use this 80's version of sterilizing which NO VACCINE ACCOMPLISHES and ignore that the mucosal response with Novavax is well documented.
Which by the context of their switch from mucosal to sterilizing means they understand this definition.
But quite a bit is being lost in the confusion.... and it's not just the anti-vaxxer tropes...
Vaccines do not sterilize your body from a pathogen, we see these latent pathogens sticking around to cause autoimmune disorders later in life and this is becoming a lot more clear lately.
What they do accomplish is they speed up the immune response so that you can clear a virus faster.
That's called "immunity" which comes in varying degrees from no symptoms at all to less symptoms in more complicated situations. You probably realize this but just covering it for everyone.
But the distinction is that in order to be sterilizing it has to have an upper respiratory mucosal response as well as a lower respiratory response.
Lower respiratory responses are pretty easy to accomplish with intramuscular vaccines but not so much for the upper respiratory tract.
A lot of folks don't know this, but our mucosal system is actually the single largest part of our immune systems and is traditionally left untouched by most of our vaccines leaving lots of room for viruses to proliferate without symptoms.
It's the top and bottom of our digestive tract among other things... places where persistent viral reservoirs are known to exist.
And while this response can block infection, in a high viral load situation it's more likely to help you clear the virus faster and hopefully have less persistent virus or viral reservoirs.
It boosts your immune system essentially but from different angles depending on where the response comes from.
This is technically sterilizing immunity in the scientific terms because it creates a mucosal response that can but might not always block infection.
Essentially your "risk is never zero" is true here too.
The problem is that it's almost impossible to prove when it blocks infection entirely without unethical testing that would require forced infections... An RCT that shouldn't exist.
And one Novavax alone does not create this response, it takes three in a specific timing... which the CDC gave us the guidance requirements to help people reach for it without lying.
This year was like a Dallas Buyers Club of people jumping state lines, going to other countries, and even creating whole new identities just so they could reach for this response...
We don't have to do that anymore.
They adopted my strategy for the purpose of reaching for it.
This happened and a lot of folks are mad about it which is why they are working overtime to defame this situation and the potential that this might be real.
But it's not so much about me not being right as it is them not wanting too admit they were wrong.
The point is, if Novavax can create a mucosal response at all then that is a huge accomplishment over our traditional vaccines, and this effect is well documented in multiple studies...
This is the effect of the Matrix M and it compounds the response of each vaccine, which mRNA cannot do...
But this idea that our old school vaccines or that even a mucosal response will ALWAYS stop an infection entirely is entirely science fiction. I admit I didn't understand that as well when I started this process, but I understand it now.
That's called "learning"... which requires admitting that you got something wrong... This is a critical function for dealing with a novel virus as we learn new things about it over time.
Something else we've learned is the virus is changing...
When SARS2 had a lower infectious load Nova was more likely to block infection but we've watched Novavax lose efficacy because COVID has increased its viral load and become more infectious.
It's still well within effective limits, but we have seen a documented reduction in preventing infection that aligns with SARS2 becoming more infectious.
This is happening because of the rampant spread of the virus and the mutations that come with it as it gets better at infecting people.
Remember, had we used Novavax the same way we used mRNA then we would have seen the desired outcomes that would have prevented these advanced mutations and we wouldn't have our bar of efficacy as low as simply fewer hospitalizations.
On a side note, the fact that we are even measuring Novavax from the position of "stopping infection" vs "fewer hospitalizations" with mRNA is everything you need to know about the differences in products.
But if Novavax can stop infection in some situations because of this mucosal response then that means it works well as a "Swiss cheese" element or part of the "game of fractions"; this is when we add mitigations in stacks so that each cuts viral load down... but with a high enough viral load or the right mutated variant then you will still see an infection.
We've seen people with 4x Novavax and all the right timing get COVID with an N95 on... the hope is that they can clear it faster. Hopefully, the days of infection will be fewer and the risk of LC is lower...
There is just only so much we can control in our current environment.
I say again... your risk is never zero.
But when it comes to "sterilizing" or "mucosal response" we've updated those terms and listening to most folks talk about it would require a time machine for it to be correct.
This is not some simple concept with no repercussions...
People will die because folks are touting this as misinformation and we risk losing Novavax as a product entirely.
But losing Novavax as a product is the point of calling it misinformation... These folks would rather us lose the product entirely and you have subpar protection then learn from the situation and admit they were wrong.
In this situation, the bad outcome happens because of inaction and an unwillingness to adapt to new information.
Or there's always the other option...
It could be that just like all the other bad things we experience lately where we find out later that it was ultimately intentional... that these "experts" help bring it on by pretending they care about folks but by simply calling important information misinformation they lead them the wrong direction.
They do it with compassion and confidence, while intentionally misleading people from accurate information.
This is abusing the trust society gave them and it seems like they were given that trust for the purpose of abusing it.
It's not like this situation just started, they've been saying this science wrong the whole time... for over two years.
We see this behavior all around us, and this is probably no different.
Something has to be done before it's too late.
Everyone deserves better.
It's pretty depressing that when I say Novavax creates a mucosal response that folks are still melting down and coming back with "Novavax is not sterilizing" while calling it misinformation.
@Friesein and I talked about it a while ago and I've been slowly phasing out the term "sterilizing" and instead refer to it as the mucosal response... because the mucosal response is well documented and it's essentially the same thing...
But the debate about what sterilizing means when you use that word is a bit more complicated and controversial.
Keep in mind, I say mucosal and they respond with sterilizing which already is very confusing...
But this means they know that mucosal means sterilizing but they doubt the science behind it without even looking at it, muddying up the explanation in the process and that confuses folks further.
So, let's break it down.
Novavax creates a mucosal response mRNA does not and this is well documented. This response is considered sterilizing but saying sterilizing does not traditionally mean it 100% blocks infection, even to what extent Novavax does this is unclear...
It's a difficult thing to measure in real terms.
This misplaced definition of sterilizing is actually an old antivaxxer trope that has slowly made it's way mainstream that argues that all vaccines are ineffective because of this.
These tropes are being repeated by mRNA advocates playing expert on the internet, when they use this 80's version of sterilizing which NO VACCINE ACCOMPLISHES and ignore that the mucosal response with Novavax is well documented.
Which by the context of their switch from mucosal to sterilizing means they understand this definition.
But quite a bit is being lost in the confusion.... and it's not just the anti-vaxxer tropes...
Vaccines do not sterilize your body from a pathogen, we see these latent pathogens sticking around to cause autoimmune disorders later in life and this is becoming a lot more clear lately.
What they do accomplish is they speed up the immune response so that you can clear a virus faster.
That's called "immunity" which comes in varying degrees from no symptoms at all to less symptoms in more complicated situations. You probably realize this but just covering it for everyone.
But the distinction is that in order to be sterilizing it has to have an upper respiratory mucosal response as well as a lower respiratory response.
Lower respiratory responses are pretty easy to accomplish with intramuscular vaccines but not so much for the upper respiratory tract.
A lot of folks don't know this, but our mucosal system is actually the single largest part of our immune systems and is traditionally left untouched by most of our vaccines leaving lots of room for viruses to proliferate without symptoms.
It's the top and bottom of our digestive tract among other things... places where persistent viral reservoirs are known to exist.
And while this response can block infection, in a high viral load situation it's more likely to help you clear the virus faster and hopefully have less persistent virus or viral reservoirs.
It boosts your immune system essentially but from different angles depending on where the response comes from.
This is technically sterilizing immunity in the scientific terms because it creates a mucosal response that can but might not always block infection.
Essentially your "risk is never zero" is true here too.
The problem is that it's almost impossible to prove when it blocks infection entirely without unethical testing that would require forced infections... An RCT that shouldn't exist.
And one Novavax alone does not create this response, it takes three in a specific timing... which the CDC gave us the guidance requirements to help people reach for it without lying.
This year was like a Dallas Buyers Club of people jumping state lines, going to other countries, and even creating whole new identities just so they could reach for this response...
We don't have to do that anymore.
They adopted my strategy for the purpose of reaching for it.
This happened and a lot of folks are mad about it which is why they are working overtime to defame this situation and the potential that this might be real.
But it's not so much about me not being right as it is them not wanting too admit they were wrong.
The point is, if Novavax can create a mucosal response at all then that is a huge accomplishment over our traditional vaccines, and this effect is well documented in multiple studies...
This is the effect of the Matrix M and it compounds the response of each vaccine, which mRNA cannot do...
But this idea that our old school vaccines or that even a mucosal response will ALWAYS stop an infection entirely is entirely science fiction. I admit I didn't understand that as well when I started this process, but I understand it now.
That's called "learning"... which requires admitting that you got something wrong... This is a critical function for dealing with a novel virus as we learn new things about it over time.
Something else we've learned is the virus is changing...
When SARS2 had a lower infectious load Nova was more likely to block infection but we've watched Novavax lose efficacy because COVID has increased its viral load and become more infectious.
It's still well within effective limits, but we have seen a documented reduction in preventing infection that aligns with SARS2 becoming more infectious.
This is happening because of the rampant spread of the virus and the mutations that come with it as it gets better at infecting people.
Remember, had we used Novavax the same way we used mRNA then we would have seen the desired outcomes that would have prevented these advanced mutations and we wouldn't have our bar of efficacy as low as simply fewer hospitalizations.
On a side note, the fact that we are even measuring Novavax from the position of "stopping infection" vs "fewer hospitalizations" with mRNA is everything you need to know about the differences in products.
But if Novavax can stop infection in some situations because of this mucosal response then that means it works well as a "Swiss cheese" element or part of the "game of fractions"; this is when we add mitigations in stacks so that each cuts viral load down... but with a high enough viral load or the right mutated variant then you will still see an infection.
We've seen people with 4x Novavax and all the right timing get COVID with an N95 on... the hope is that they can clear it faster. Hopefully, the days of infection will be fewer and the risk of LC is lower...
There is just only so much we can control in our current environment.
I say again... your risk is never zero.
But when it comes to "sterilizing" or "mucosal response" we've updated those terms and listening to most folks talk about it would require a time machine for it to be correct.
This is not some simple concept with no repercussions...
People will die because folks are touting this as misinformation and we risk losing Novavax as a product entirely.
But losing Novavax as a product is the point of calling it misinformation... These folks would rather us lose the product entirely and you have subpar protection then learn from the situation and admit they were wrong.
In this situation, the bad outcome happens because of inaction and an unwillingness to adapt to new information.
Or there's always the other option...
It could be that just like all the other bad things we experience lately where we find out later that it was ultimately intentional... that these "experts" help bring it on by pretending they care about folks but by simply calling important information misinformation they lead them the wrong direction.
They do it with compassion and confidence, while intentionally misleading people from accurate information.
This is abusing the trust society gave them and it seems like they were given that trust for the purpose of abusing it.
It's not like this situation just started, they've been saying this science wrong the whole time... for over two years.
We see this behavior all around us, and this is probably no different.
Something has to be done before it's too late.
Everyone deserves better.
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