People discussing how their Long COVID symptoms are improving after receiving the Novavax COVID vaccine have begun appearing on social media.

This is a big f--king deal, because I proved YEARS ago that Long COVID and even other chronic illnesses are driven by general persistence of pathogens with the reduction in symptoms after multiple doses of Novavax.

The reason you haven't been able to access Novavax is because the mechanism that increases the breadth of your antibodies...

Increases the breadth of ALL your antibodies, not just COVID.

So, that persistent virus that mutated just outside of your immune range created at the start of your infection is now vulnerable to your immune system.

With Novavax, we aren't just protecting you from COVID...

We are crushing the chronic illness industry by giving your immune system the tools to beat your chronic illness, IF a persistent pathogen is driving it...

However, almost all pathogens are persistent to some extent.

The mechanism is in the adjuvant... We could probably just administer the adjuvant alone and observe a reduction in chronic illness across the board...

And that's precisely what we are going to do.

Buckle up, because this was never just about COVID.

However, you can also get the best protection against that novel virus at the same time. Let me explain, the adjuvant and the antigen are not combined in the vaccine; they are separate parts.

Additional vaccines increase the breadth of PREEXISTING ANTIBODIES.

That means it's increasing the breadth of all your antibodies.

It's incredibly straightforward and has already been demonstrated in real-world activity multiple times.

We simply have not performed a trial.

We have less than five hours to do something that will be both funny and protect immunocompromised folks.

But I need you to act on it right now; I also need you to interact with this post because time is running out quickly.

pharmac.govt.nz/news-and-resou…

We have about five hours.

New Zealand is taking public comments for next year's COVID vaccine, and they are currently planning on only getting Pfizer.

We can argue the protective levels of mRNA all day, but we can say with total certainty that many people have mRNA intolerance, and they are often the people who need these vaccines the most.

New Zealand needs to offer a protein-based alternative for folks with mRNA intolerance...

And with Novavax's single-use vial being approved in the US via BLA, we can assume other countries can also start using it, putting aside issues with expiration dates.

The deadline is 5 pm on the fifth, but because of time zone differences, it's already roughly noon on the fifth at the time of writing this.

You do not need to be in New Zealand to comment.

So, please comment multiple times.

This will help immunocompromised and disabled folks there.

You can read the full breakdown here, where they discuss vaccines being made available from other brands if there are intolerance issues. Here is the link to just the page where you write your comment.

pharmac.govt.nz/news-and-resou…

The NIH funded a bunch of LC groups to lie about prevalence.

They acted like they were everyone's buddies and wanted to help, so they slapped LC on their group's name and then got everyone to tell the lies the NIH and Biden admin wanted, so it would hide the disease.

It was their monumental fuck up that caused it all so instead of doing something they spent billions convincing people they didn't have it.

Which mostly worked, too, except all the dying and misery.

It was all those groups begging for RECOVER money and trying to keep that funding going.

They were always a scam to minimize understanding and progress.

But you know, their group had LC in their name so they must know things, right? The problem is that the LC community has insanely high turnover from new people getting sick, others getting better, or worse, dying.

So, it means you constantly have a new group of people who still believe in the system, the one that just gave them LC, so they look for institutional help.

Even though it's that institution that put them there, but they don't get that yet and won't until they've alienated all the people actually trying to help them

**Novavax Update**

ACIP (CDC) public comment

I'm writing a call to action, but it's a bit more complicated than usual, so it's taking longer.

I was rushing to include a push for ACIP public comment. However, public comment closes tomorrow.

So, I'm decoupling the two. I already wrote an article about public comment. For the time being, refer to that.

I need you to do this right now, within the next 24 hours.

And yes, it's the FDA, not the CDC, holding up approval. However, they are both part of the HHS, which RFK is in charge of.

And it looks like he's holding control over all decision-making.

We have three main points for the CDC...

Novavax’s immediate BLA approval.

Expansion for access under twelve.

The expiration date needs to be moved from three to six or nine months.

The link to make a public comment is directly below this tweet.

I will also explain what needs to be done in greater detail on the show this evening, we have to make a huge leap to make this happen. Link to public comment
regulations.gov/docket/CDC-202…

**Novavax update**

Looks like we have official word on a few things.

1. There are vaccines that expire in April, but most batches expire at the end of this month.

2. There will be no new batches distributed by Novavax for this season.

3. In theory, the FDA could extend the expiration date to nine months, as other countries have done. However, there's been no sign of this happening.

4. Sanofi will be taking over distribution for future vaccine seasons. I am unsure if that will be the Novavax product they distribute or the same product they produced. I think in the US, it will stay Novavax but be distributed by Sanofi.

5. Pediatric expansion can happen now under EUA, but it is expected to happen (according to the previous administration) after the BLA is approved.

That brings us to the problem.

5. Novavax needs the FDA to formally accept their BLA in April, which is tied to their deal with Sanofi.

6. There is significantly concerning chatter that short sellers are plotting to prevent the BLA from going through.

This could mean no more Novavax products or approvals, and it will certainly put their Sanofi deal at risk.

We'll need to put together a focused effort in April to ensure that we can push this BLA through at the new FDA.

And it's three steps.

a) Extend Novavax's expiration date so that the April batch stays on the shelf until new doses are approved.

b) Push through the BLA at the new FDA.

c) Ensure that pediatric access happens for the next vaccine season at the latest.

That's it... Two of those things need to happen in April... Pediatric access will be a few months later.

There will be more updates. Unfortunately, our next show isn't until April 1st, but that's when we will start the push to take action on this.

x.com/i/spaces/1OdKr…

Dear everyone who wants a blood test to check for Long COVID...

Red blood cells do not have a nucleus, and though COVID can infect them and form syncytia...

It cannot replicate inside of them without said nucleus.

We remove white blood cells for transfusion, so at your best, you'd probably want to check the white blood cells instead of the red ones...

But you knew that already, right?

Right...?

This whole thing just gives Theranos vibes.

You cannot measure a small amount of blood to find a disease in the cells... We will find it in some cases; some people will have COVID in their blood... this is what creates the catastrophic heart risk...

But, generally speaking, it's just not how it works, except in rare cases.

There are a number of excellent documentaries that cover this idea.

However, they are all about Elizabeth Holmes.

We do, on the other hand, have scanners that can detect COVID in your body by seeing the damage that it is causing but not the virus itself, though we don't have many of them.

It's sorta like how we measure black holes, in that we can't measure the black hole itself, but we can measure its effect on its surroundings

And I wonder why no one ever talks about these scanners and processes. Fun fact: About 14 years ago, I helped a team working on black hole theory with this concept, which led to several advances in how we measure black holes.

It wasn't anything fancy; it was just an ask for help on Reddit, but they used the theory I gave them to get past what they were stuck on.

We cannot measure a black hole with standard diagnostics, but we can measure the impact of the gravitational waves it creates on the things around it.

Finding persistence is the same thing.

We don't do great at measuring individual viruses in cells, but we can easily measure the damage that we would expect to see if the virus were persistent.

But in order to do that, you have to understand syncytial theory because it creates the damage we would detect.

That is why I explain these things together: they are all required to understand to solve the problem.

Most don't seem to understand a single part, let alone the whole thing.

So, bit of an update on more mRNA vaccines coming to market.

This is all pretty much verbatim from the meeting notes that were released a day or so ago.

VRBPAC is meeting tomorrow because the mRNA RSV vaccine is making infections in infants worse...

It's actually a similar effect we see in some mRNA COVID vaccines, or at least concern has been discussed...

And there is significant concern that the RSV vaccine is boosting the infection instead of stopping it.

It might also counteract or be counteracted by other mABS treatments which are more effective.

Moderna even had a clinical hold put on their trials but they declined to tell the public about it.

The expansion for mRNA RSV to kids is dead in the water, and they decided not to move forward with the testing.

The meeting is to determine if it should be pulled for adults too.

Not a smooth rollout for the 2nd mRNA product. @tkweeks01 @Friesein

We gotta stop repeating that only 5-10% of people get Long COVID.

It's not only not a scientific assertion it's not actually based on anything real.

Persistence happens in EVERY infection but only some have symptoms.

ndtv.com/feature/long-c… The basis of these studies is QUITE LITERALLY self diagnosis.

And the number moves wildly depending on how the testing is done.

Claiming this is some objective fact is total minimizer bullshit.

We are only testing for symptomatic self diagnosis and that's all it means.

Another day with another study showing that I am still the only person who knows how to treat Long COVID.

I haven't read this in detail, but I will.

Pretty much expected results.

Also, endothelial inflammation is caused by syncytial formation of persistent virus.

Even the most basic labeling is done incorrectly. Syncytial formation in the inner lining of our veins is the one place we have really good studies on this mechanic.

But they couldn't even do well enough to read those.

journals.plos.org/plospathogens/…

After taking a bit of a break my interaction level is very low.

And that's not great because I have a call to action with a very short timetable. So, I'm going to need your help to make sure this information makes it to the people who we need to take action.

VRBPAC (FDA) announced a meeting with almost no leeway to set up a presentation and limited time even to work out a public comment push.

Public comments are due by 11:59 eastern on the 9th.

There are currently only FOUR comments.

The meeting is about vaccines for, among other things, H5N1.

Now, the FDA and CDC are making predictable mistakes regarding H5N1 and that should bother everyone.

We live in the shadow of a pandemic that folks want to ignore while another one is looming...

And me saying "looming" is not me being dramatic, the FDA is already stockpiling millions of H5N1 vaccines...

But their strategy has some big problems.

H5N1 or Bovine Influenza A is creeping its way into the human population but it's doing it only through the immediate workers who handle cows or poultry.

And instead of vaccinating those people and their families with a powerful vaccine that keep this new flu out of the human population...

They are stockpiling millions of doses in anticipation of a nationwide outbreak, it is unclear the level of protection they will provide but based on the FDA's acceptable levels... it's not looking good.

The approach to efficacy in general has been so watered down... they call vaccines with low efficacy "high efficacy" because efficacy as a concept is not on a sliding scale it is simply ANY immunity which is also a broadly defined concept.

This is leaving too much wiggle room for less effective products to be widely used and that makes our response ineffective.

So, we are preparing for the next pandemic by allowing it to first escape into the human population before we act...

This simply feels like an opportunity for pharmaceutical companies to create new markets, with new drugs, and new long term symptoms all based on a neurotropic disease that has completely unknown ramifications but we know it starts in people's brains because the current entry point is the eyes.

We need vaccines that stop transmission at the source and prevent this from entering the human population.

That should be our goal and nothing else should be acceptable.

We are currently preparing millions of vaccines while simultaneously accepting low levels of protection that are sold to the public as "high efficacy" while sitting on our hands in preparation for it to explode in the general population...

A population that has recently been randomly immunocompromised by rampant COVID infections.

This will give the virus opportunities to mutate and we have literally no idea what comes after that...

But it won't be good.

It seems like the purpose of this strategy is to create new treatments for markets with the public, but minimizing will run rampant... their treatments will likely fail... and the public will be left holding the bag with a new list of long term symptoms and a new version of the flu with no way to control it.

I've had sequelae three times in my life and the one I got from the flu in 2009 was completely life changing.

If we are preparing to combine that with Long COVID then we will be left with a suffering population and little room to recover.

We need to demand the FDA reach for more protective vaccines that stop transmission of H5N1.

Hopefully that will be the beginning of a larger trend where stopping transmission is the focus again of our vaccines and then we can put common sense ideas like eradication of these parasites on the table.

I have a larger article with sources that should be out tomorrow.... Hopefully that will help anyone on the fence with writing a quick comment.

But you might think, "Don, this has nothing to do with COVID or Novavax. Why should I care?"

Our problems with handling COVID are part of a larger structural issue on how we are approaching disease from the position of management instead of mitigation.

I have sat through these meetings for a few years now and there is ZERO effort to actually stop transmission while instead they focus on simply making the disease more manageable while ignoring any long term consequence that isn't actual death.

That means everyone's quality of life is on the chopping block...

If we were to use our current influenza shots as the basis for efficacy then we are looking at only a 40-50% protection from hospitalization and that is totally unacceptable.

They imply that this low efficacy is because of our limitations but that isn't true at all, it's the explicit goal.

Novavax has shown that not only is that not our limit, that when we try to go further the FDA actually stops manufactures from offering this level of protection...

AND THIS IS A PROBLEM.

So, like many of the issues surrounding COVID, we have to come at this problem sideways and push for more structural changes that will go on to affect our COVID response instead of trying to change the entire situation from simply our COVID response alone.

We have to meet people where they are and that includes are regulators...

So...

That means we need to demand more protective vaccines that stop transmission of H5N1 so that dairy workers cannot get infected or transmit it to their families where it will then enter the school population and on to circulate among other families as it enters the general population where it becomes much much harder to stop.

We need to cut this off at the source.

We simply do not know what is going to happen but the outlook is grim and we simply don't need that when the pharma corporations who are trying to create this market simply cannot control enough of the people in our environment to make it safe.

We must use the precautionary principle, and assume that long term consequences will be equal to or greater than our worst flu outbreaks, think swine flu instead of seasonal, and that means millions of hurt people.

H5N1 still has a while to go before it infects humans with ease, but it's coming, and that actually makes it easier to cut it off here and protect all people.

The FDA putting a higher expectation on manufacturers to produce more protective vaccines for H5N1 that stop transmission will not only protect the general population, but it also directly protect these workers and their families.

Please take a moment and write a comment to that effect.

The link to comment is in the next tweet. Here's the link to the public comment page.



Please demand that the FDA work with manufactures to create vaccines for H5N1 that stop transmission at the source.

We need to prevent this new pandemic from starting, not see it as part of a profit driven model.regulations.gov/document/FDA-2…

A lot of folks ask me about Novavax timing, and I am still writing a final article, but this seems as good as time as any to explain how this appears to work best.

Again sources will be in the article, or can be found in one of my earlier articles, so this is just the details.

First important part, unless you got a KP.2 updated mRNA then all your mRNA before doesn't matter when thinking about what you are going to do next.

It's not the most popular idea but there is no clinical benefit to mRNA shots you had over six months ago to the response we aim for now.

Some folks will talk about immune memory response and that's true but not the relevant data point for this.

More on immune memory later.

There is a 2 months rule in all these vaccines that we worked hard to get the FDA to accept widely...

IT IS FOR SAFETY.

These vaccines are safe when they are administered properly, please do not plan to get any COVID vaccines more often than two months apart unless you have extreme circumstances or are working with a Doctor.

Also, give our Twitter show a follow before everyone bugs out for the next few months, we have to reach more people so as they say the show must go on.

@BFIshow

Okay, I think I can cover most of the bigger groups.

1. If you are switching to Novavax from mRNA or only got one Novavax last year or only the two the year before that... Then you are effectively starting over.

- You want to get two shots two months apart and then a third at six months after the second shot... so eight months total. The current rules are for any vaccine as long as it is two month since your last but that doesn't mean getting it'll be smooth and we will likely have to help those people on an individual basis when they go to get their second... It should be easier than last year.

2. If you already got 2 or more Novavax of the XBB.1.5... It's been between 6-9 months for almost everyone but if you are closer it's okay. No need to wait to get an update.

- You want to get one Novavax right now and another in six months, the FDA is likely to approve a second vaccine in six months so don't worry about it yet.

3. If you already got three Novavax, last within a year.

- One updated JN.1 is enough but we're likely to see significant mutations over the winter season so we are almost certainly going to want to get a second JN.1 to increase the breath or range of our antibodies. Matrix M overcomes the imprinting issue but it takes multiple shots to help with new variants beyond our current ones. That can happen either after two months or when the second shot is approved.

4. If you are concerned about your memory response.

- Get two as long as they are two months apart, it will still help with antibody range in that shorter time.

5. If you are immunocompromised.

- Get two at least two months apart. Winter is going to be nuts this year and you're going to want to be ahead of the antibody range. The rule for extra shots is literally for you all on paper so use it.

6. You are aiming for persistent virus reduction.

- Three shots two months apart each. Find a Doctor to work with on this and we can provide you information to show them so they are onboard. That way you can also be monitored safely. This is why it's 2 months apart with no clear end for IC folks. This was part of our presentation last year and if you have a doctor involved then getting the additional shots will be no issue.

7. You got KP.2 mRNA a few weeks ago.

- Everyone who gets mRNA will need two vaccines this season because of the imprinting issue Matrix-M overcomes. So, you want to either wait at least two months and get a Novavax or another mRNA or you can wait until the next vaccine is approved in six months or so.

8. You got KP.2 and you want to switch completely.

- Technically, having mRNA for the start of your new Novavax series is not ideal but it gets pretty close in most easily measurable ways. When we talk about vaccine exposure after multiple shots a lot more is about the adjuvant than the antigen though both play a role of course. So, you would get the second shot as Novavax at least two months after your KP.2 then another Novavax at six months. Then you would update like normal and after your third Novavax you are basically caught up. It takes a bit longer but you are consistently protected while you make the change.

9. So the basic timing?

- Two shots two months apart with a third at six months.

Then it's a booster no sooner than six months, you just don't need it, and by the 8-10th month some of the more complex protection starts to wane. So, if you are high risk in any way then you probably want to stick with that timing but you can technically go longer between shots.

If you go longer than 18 months between Novavax then it's likely you want to start over but two six months apart should catch you up... looking for more data on that as we go forward.

I am currently one year from my last Novavax and I will get one now and likely a second in six months or in Dec if COVID is really bad.

Then I should be good for a while even if we have big mutational jumps. We would need another event like JN.1 which we saw coming for a year to need an update.

But should we need an update you can get it as soon as it is available and restart your timing from that as if it was your third shot in the three shot series.

I hope this helps.

While this is helpful for Twix, in order to convince your family members and such to get vaccinated again to protect themselves this winter it will take the more convincing sourced article.

It's my priority item so it should be done in time to still help folks convince our loved ones to better protect themselves and any work we can do to lessen this winter wave that is coming.

Oh, and don't forget... we have to push for the pediatric vaccine and now Japan has approved it for 6 years and older... so they are ahead of us in pediatric applications.

Americans paid for Novavax as part of Operation Warp Speed...

Plus, we have to keep up the pressure at the FDA so we don't have to keep going through this. Especially with looming expiration dates already because of the new single dose shots. If you want to follow my substack, one of my other social medias, or make a contribution to the work...

You can find all that on my linktree --->linktr.ee/donford

So a few months ago we hatched a wild plan thanks to @tkweeks01…

The only way to get COVID protections in hospitals is to make it so COVID is added to the list of hospital acquired infections that stop Medicare and Medicaid from paying out…

And we were all writing in a bit ago…

Well, I got an update… it’s working.

Also, they have to report COVID infections starting in Nov…

That’s what winning looks like. This is all stuff we work out live on our show twice a week.

Join us sometime. It could save your life.

x.com/bfishow?s=21&t…

I need folks to help put a ton of pressure on the FDA.

Basically, Novavax is not like mRNA... while mRNA has a short protective window that cannot be stacked on previous vaccines...

Novavax can build on previous vaccination and does not have a short window in the same way.

Well, great news... the @US_FDA plans to mislead the American public and limit access to all COVID vaccines on the basis of the limited real world effectiveness of mRNA....

That means no updated Novavax until Sept. while it should be ready by the end of the month...

Leaving all the folks who need Novavax in the dust.

We need folks to start calling the FDA... literally every day.

Until they release the current JN.1 Novavax because no other versions of the vaccine will be available until then.

There are at least a half dozen other reasons why this is a good idea but we need to push EXTREMELY hard on the FDA to approve it for release ASAP.

We're probably going to have to be super annoying about this... make it personal.

Also, reminder that the pediatric Novavax that they are playing games with is the EXACT SAME SHOT that you are hoping to get.

I think it really screams Novavax is actually better when they withhold it without any due cause...

Get creative but the petition and the FDA contact info is in the first comment. Call the FDA at 1-888-463-6332

Being obnoxious is technically legal.

actionnetwork.org/petitions/dema…

Fun Fact: Releasing Novavax's JN.1 now won't actually hurt anyone or the ability to sell KP.2 vaccines in Sept.

But not letting Novavax release it's JN.1 vaccine as soon as possible will create harm when no Novavax is currently available and folks can't take mRNA.

This reminds me a word but I can't put my finger on it... It's not like everyone knows that folks will take the first vaccine available no matter which one it is...

Right?

It's not like that data is presented at these vaccines hearings or anything.

Since folks are still trying to prove how little they know about COVID and how the variants work...

JN.1 and KP.2 are two mutations different on the RBD.

It's essentially the same variant.

mRNA is using KP.2 because benefits from being slightly closer because it's an INFERIOR PRODUCT.

So, now we see people trying to lie to you and trick you about what is best...

But we got the receipts... and participated in the meeting.

A lot of people are proving to all of us that after all this they still do not understand the subject better or how to make a decision that is best for the public.

But don't worry... we got you. What everyone is missing is that we all need two shots to update imprinting and Novavax is the ONLY vaccine that increases range of your antibodies.

So, while mRNA will get stuck at KP.2... even if you get two.

You get two Novavax and it rises to meet the variants we can't see yet.

I mean, this is a complete checkmate and they don't even understand why.

And I got 2.5 months to explain it.

This won't even be hard.

American college students are demanding a ceasefire...

So, what does Biden do?

Has cops show up to fire at them.

"You want a ceasefire? How about some non lethal rounds..?"

Which are not only toxic but are supposed to be shot at the ground so they ricochet but instead they are pointing them in people's faces...

Guess what? They are just lethal rounds when used that way.

At least Biden said to just shoot them in the leg, an actual quote... but naturally the police mocked him for suggesting anywhere but the face like the Zionists taught them.

Make no mistake, the point is to scar these students so they are easier to spot in the future just like they do to Palestinians.

The point is to maim them.

If this is what "protecting democracy" looks like then I don't want it. BTW... that part about the leg and the cops is 100% real.

fox13news.com/news/police-ri…

Every single person who doesn't care about COVID is a person who will care about COVID in the future...

But for most it will happen in the hospital bed when it's too late to do anything for them.

They've made their bed, we should simply prepare for the fallout...

And all the room they'll make for activities.

I'm not even sad anymore, I just feel nothing for these folks.

I wish it weren't like that but we have to start protecting ourselves emotionally in ways that we are not prepared for.

Their indifference toward the death of others has made me indifferent about their eventual premature passing. I used to care... but I just don't anymore.

I've seen so many dead children with 100s of people defending their slaughter.

And I think I am prepared to do what is necessary now.

We have to let them go... and prepare for what's next.

This is what Long COVID cognitive dysfunction looks like.

I know folks are always going on about Bob's takes...

But this is the sign of a legit disability and shift in his perception of risk.

We think he's lying for the corps... but he's not... his brain is damaged and his risk appetite is shifted.

This is cognitive Long COVID, it's subtle... but kills. It's likely he had asymptomatic brain invasion because his upper respiratory protection was limited without proper respirators.

So, we're seeing the negative outcomes of the risk appetite shift that occurs when the brain is damaged.

This is NOT cytokine damage... this is more permanent CTE like damage that has occurred...

I wonder if he finds himself raging in private lately.

Mass infection for immunity to SARS2 does not work.

And I'd like to explain to you why.

The thing that folks don't realize about SARS2 is the incredible quantity of viral particles in an infection... back during Delta it was understood that during peak infection there were more viral particles than your own cells.

It is understood as having a higher volume now but is less concentrated in your lungs... this is not actually a good thing.

Don't worry though, you aren't more SARS2 than human because SARS2 is very small so by volume it's still substantially less. *laughs nervously*

But when it comes to mutational capability in a certain amount of time... this is not what we want to see.

There is an old joke about an unlimited amount of monkeys typing on an unlimited amount of typewriters. google typewriter if you aren't sure what that is... and how eventually given enough time one of them will write out the entire collected works of Shakespeare...

Or at least the works attributed to him, more likely a them as were learning it's likely more than one person... you know what? I'm off subject... And technically if it's infinite it would do it instantly... but I'm not rewriting it.

Point is that SARS2 follows a similar idea... it's a vast amount of monkeys on a vast amount of typewriters IN EVERY INFECTION.

It's not infinite but it sure can feel like it...

And it is likely to find an immune evasive combination in that sheer overwhelming volume of mutation possibilities.

When it does that, this version of the virus will proliferate better without challenge from your immune system becoming the new dominant variant in your infection.

This process is very straight forward...

Basically, SARS2 hijacks our cells then it uses ribosomes to print spike protein, same way the mRNA vaccines work, and that means that occasionally the ribosomes misprint the amino acids and you end up with different mutations.

This process is very similar to the "Frame Skipping" that we were discussing regarding the mRNA vaccines but instead of code being read wrong... it's more like a printer error that can be linked to a specific printer.

But ribosomes themselves only have so many possibilities so you end up with the same misprints across a broad spectrum of people.

Those mutations can be total shit... they can be... basically whatever... but occasionally they gain immune evasion and that can become persistent virus, hiding out invisible to your immune system... actively creating more virus and more mutations...

But occasionally it can gain immune evasion AND fitness...

And that's how you get new variants of concern.

The problem we are currently learning about is that BA.2.86 only needs a small ribosome misprint to end up at JN.1 which is an extremely immune evasive variant to ... everything ... vaccines will hold up, for now, and to avoid this turning into a Novavax commercial, I'll leave it there.

Point is that infection based immunity is a total clusterfuck... With any reinfection you are almost immediately seeing a new variant with immune evasion to your previous antibodies or memory response...

Because that's why this new variants exists at all.

(We're not even going to bring IgG4 up here but it makes it even more confusing... and don't even get me started on asymptomatic responses...anywho...)

It gained misprints/mutations that equate to immune evasion and that allowed it to be passed on to someone who already had infection based immunity.

That's just how this works, that is how this will always work.

It's just that sometimes SARS2 gets itself backed into a corner where it can't stack mutations well enough and it is has a harder time finding that right combination...

And this gives folks a false sense of security.

But with this many active hosts and cryptic lineages there are more than enough recombinant possibilities that eventually it will find a way if left to its own devices...

Because given enough time, those monkeys are going to write out the collected works of Shakespeare simply due to the sheer quantity of viral particles in an infection and every single individual one has the capability to start the process I am describing.

Simply put... mass infection for immunity will NEVER work.

And don't let anyone gaslight you into thinking that means "herd immunity"... Herd immunity is when you vaccinate enough people with a non leaky vaccine that those who the vaccine does not work on will still be protected.

We've barely even tried to make that happen...

But were going to have to because...

Mass infection for immunity to SARS2 does not work.

It will only shorten people's lives. BTW regarding herd immunity... Twitter has a gif for that.

I am deeply disturbed that I am the only person on the planet discussing the actual mechanics of the damage COVID is causing and how it's altering the internalized concept of risk in the infected.

COVID is shifting folks' risk appetite making people do more and more dangerous things and most folks don't realize it.

While the world burns. Keep in mind, everyone focuses on just the damage the virus does... which also no one else explains the syncytial mechanics.

But it's actually our organic mammal response to infection that causes most of the effect.

It's a mammal's response to infection that triggers it.

And no one on the planet is talking about this effect.

We need to figure out how to get the @US_FDA to approve Novavax but now everything is up to @DrCaliff_FDA...

And he's a bit of a road block for progress.

So, my suggestion is a brute force style attack... find any @fda email and start emailing them about Novavax approval. @US_FDA @DrCaliff_FDA @FDA It might seem like a bit of a broad stroke...

but let's get honest... this is a digital protest.

Our best shot is for the internal members of the FDA and CDC be so annoyed with us mucking up their communication that they just give us what we want.

We're going to repeat this...