Thread by @Helios_Movement

The first study that reported the association between the MTHFR (C677T) genotype and AA (Alopecia Areata).

*Not in depth*

pubmed.ncbi.nlm.nih.gov/23954881/

Methylation 101👇

First things first.
1. An alkane, consists of hydrogen and carbon atoms (CnH2n+2) that are arranged like a tree.
2. An alkyl group, is an alkane missing one hydrogen.

Why does this matter?
Because:
-Methane, contains 1 carbon atom and 4 hydrogen atoms (CH4).
-A methyl group, is derived from methane and contains 1 carbon atom and 3 hydrogen atoms (CH3).

This had to be mentioned for the definition of methylation, a form of alkylation where a methyl group is replacing a hydrogen atom to stick better.

Or as it is often referred to “the addition of a methyl group” (one carbon metabolism supplies methyl groups).

Now here are a few processes in which methylation plays a key role:
-Gene regulation, expression and embryonic development
-The regulation of neurotransmitters
-Hematopoiesis
-Energy production
-Immune responses
-Antioxidant production
-Detoxing
-Repairing damaged cells
-Metabolizing B vitamins
-The production of phosphatidylcholine, carnitine, melatonin and creatine

Now here are some things that poor methylation can exacerbate or even cause:
-Miscarriages
-Heart disease
-Arthritis
-Elevated levels of homocysteine
-Skin issues
-Anxiety
-Depression
-Migraines
-Poor cognitive function
-Autoimmune issues
-Stomach problems
-Blood clots
-Infertility
-Estrogen dominance
-Liver issues
-Hypothyroidism

So methylation is a key process that our health depends upon and poor methylation will lead to poor health.

Now how can you know if you have a methylation problem?

First of all, our genetic profile affects methylation.

Certain gene mutations for example can harm the conversion of B9.

Then we have medications such as metformin, antacids and methotrexate.

Then we have toxic burdens that include anything from alcohol, birth control pills and smoking all the way to heavy metals.

Gut issues such as SIBO that are unable to get resolved no matter what can also be a byproduct of poor methylation.

Poor nutritional habits will obviously harm methylation since things such as B2, B9, B12 and B6 all affect one carbon metabolism (which is why their mindless supplementation can also harm methylation).

Then supplementing with NAD precursors such as NAC or even B3 for months on end (once again for no reason), can result in over methylation is some people.

For more: fitandball.gumroad.com/l/thesystem23