Most people still don't truly understand the impact of thyroid dysfunction.

The thyroid gland directly communicates with the brain, the pituitary, the parathyroid, the pancreas, the liver, the adrenal glands, the intestinal system and much more.

You already know this to be true if you are suffering from any type of thyroid dysfunction but here's an example i always try to mention.

Let's suppose that you want to lose weight, well in order to put in perspective how much the thyroid gland affects our metabolism, resistance training which is promoted as one of the best tools to increase BMR, can only lead to a 10% increase (which is still great).

Now here's what's fascinating: untreated hypothyroidism can lead to a BMR that's even 40% below normal and even 50mcg of T3 per day can increase BMR by even 30% in some cases.

You can also look into for example how T3 influences the tight junctions, how it upregulates the LDL-receptor, how it helps with the release of bile or even how it facilitates the production of lactase in the intestinal tract so thyroid dysfunction could even make you react badly to dairy.

In some studies, up to 90.5% of depressed people have subnormal T3 levels.

So thyroid dysfunction could lead to things such as:
-A variety of gut issues
-Severe fatigue
-Hair thinning
-Depression
-High LDL
-Insulin resistance/metabolic dysfunctions
-Low libido
-Low testosterone
and more.

Here's how you can support its function.
Thread🧵
*Standard disclaimer that nothing in this thread should be used as a substitute for medical advice*

It's George.
Let's start with the basics.

The thyroid gland is a 2-inch-long gland that weighs less than 1 ounce and is located in the front of the neck below the larynx.

It has two lobes, one on each side of the windpipe which leads to its “butterfly” shape.

The thyroid is one of the glands that make up the endocrine system.

The glands of the endocrine system produce and store hormones and release them into the bloodstream.

The hormones then travel through the body and direct the activity of the body’s cells.

The thyroid gland makes two thyroid hormones:

-Triiodothyronine (T3)
and
-Thyroxine (T4)

How to start getting out of depression, ADHD, OCD, anxiety and panic disorders by utilizing GABA.

Thread🧵 It's George.

The brain contains a vast neural architecture where billions of cells continuously exchange information.

This complex signaling is driven by neurotransmitters, the molecular messengers responsible for cellular communication.

So by attempting to decode neurotransmitters, we are attempting to map the specific language the brain uses to send instructions and process our thoughts and emotions.

Overall, in case you are new here, neurotransmitters are chemical substances that neurons release to send signals across synapses, the tiny gaps between nerve cells.

These molecules are categorized based on their effects.

We have:

-Excitatory neurotransmitters that increase the likelihood of a neuron firing an action potential.

-Inhibitory neurotransmitters that decrease the likelihood of a neuron firing, providing a calming effect.

-Modulatory neurotransmitters that influence the overall activity of groups of neurons, modulating their function over time.

Magnesium is a non-negotiable nutrient for our well-being.

Without enough of it, we encounter problems ranging from energy crashes, insomnia and anxiety all the way to elevated blood pressure, gut and bone issues.

Yet most people are not only deficient but also use magnesium supplements incorrectly (wrong forms, doses etc).

So here's your ultimate guide to magnesium (like/share it if you find it helpful).

Thread 🧵 It’s George.

In a region of Greece called Magnesia, people had discovered a white mineral.

Since it was common practice in ancient Greece for materials and rocks to be named after the geographical area in which they were discovered, they named it: “Magnesia Alba” (white magnesia).

In ancient times, it was utilized in:

-Medicine: It was a key component of the so-called “magnesian stone” used to treat gastric disorders, as it functioned both as an antacid and a laxative.

-Therapeutic ointments: It was used in the preparation of poultices, as it was believed to aid in the healing of wounds and skin conditions.

-Cosmetics: Due to its bright white color, it was frequently used by women of that era as a face powder.

If you have anxiety, gut issues, irritability, ADHD, CFS/ME, insomnia or skin issues, histamine intolerance and MCAS could be the primary drivers behind them.

Yes there's solid research that backs this up (just tap in the pics).

Now you might be thinking, "so what you are telling me is that my generalized anxiety is just an issue with histamine?"

It could be, yes.
It's not that far-fetched.

While the average person still thinks that histamine is just something related to allergies, let’s not forget that histamine acts as a neurotransmitter in the brain, influencing things such as arousal, attention, mood, sleep, and motivation.

So when levels build up, it can create:

-Restlessness and physical + mental hyperactivity

-Difficulty concentrating, brain fog, inattention

-Irritability, impulsivity, or agitation

-Sleep disturbances (insomnia or poor sleep quality)

-Anxiety or sensory sensitivities

-Hyperarousal

-Racing thoughts, anxiety/panic, or restlessness

-Insomnia or disrupted sleep cycles (common in manic phases)

-Depressive symptoms (fatigue, brain fog, low motivation) during crashes

-Emotional lability or energy fluctuations

There are even reports noting that histamine flares can mimic manic/depressive episodes, and MCAS patients sometimes receive initial bipolar diagnoses.

So what can you do about this?
Well, give me 3 minutes and i'll lay out the basics for you 🧵


Histamine is a biogenic amine that is naturally occurring in the body and many foods.

It is synthesized by the pyridoxal phosphate-containing l-histidine decarboxylase from the amino acid histidine in mast cells, basophils, platelets, histaminergic neurons, and enterochromaffine cells.

Note: Even though histamine might be synthetized in mast cells for example, it is critical to understand that it is STORED there and it’s NOT really released without a stimuli.

This is why you will read the term “histamine liberator” later.

It was discovered in 1910 and identified as a mediator of anaphylactic reactions pretty soon after that.

Plenty of times, your depression doesn't start in your head, it starts in your mitochondria.

A lot of mental illnesses can be viewed as a "brain energy crisis".

To demonstrate this point, here's for example an ancient enzyme system that not only controls your mood but is also key when it comes to resolving some side effects of psychiatric medications.

Thread 🧵 It’s George.

If you are struggling with a mental health issue such as major depression, a form of bipolar disorder, OCD, ADHD and so on, it won’t take you long to come across potentially helpful lifestyle interventions that, at their roots, try to target various aspects of metabolic dysfunction.

Histamine intolerance and/or MCAS are criminally underdiscussed when it comes to autoimmune types of hair loss, despite their crystal clear effect.

Here's what you need to know.
Thread🧵 *Standard disclaimer that nothing in this thread should be used as a substitute for medical advice*

Now overall, histamine intolerance and/or MCAS are criminally underdiscussed when it comes to a lot of serious issues, mental health issues include.

Yet your anxiety, racing thoughts, insomnia, irritability, impulsivity and so on, are often nothing more than a little extra histamine and we have proof for this.

That's also the common link between allergies, certain types of hair loss, skin issues such as psoriasis, ADHD, insomnia and anxiety.

Of course, putting the correct label on something can take quite some time and especially when it comes to mental health issues.

Misdiagnosis rates are still notably high, even if we are talking about primary care or specialists.

Putting the correct label on something can take quite some time and especially when it comes to mental health issues.

Misdiagnosis rates are still notably high, even if we are talking about primary care or specialists.

So when levels build up it can create:

-Restlessness and physical + mental hyperactivity

-Difficulty concentrating, brain fog, inattention

-Irritability, impulsivity, or agitation

-Sleep disturbances (insomnia or poor sleep quality)

-Anxiety or sensory sensitivities

-Hyper arousal

-Racing thoughts, anxiety/panic, or restlessness

-Insomnia or disrupted sleep cycles (common in manic phases)

-Depressive symptoms (fatigue, brain fog, low motivation) during crashes

-Emotional lability or energy fluctuations

Of course, we don’t pull all these out of our asses.

There are reports noting that histamine flares can mimic manic/depressive episodes, and MCAS patients sometimes receive initial bipolar diagnoses.

Oxidative stress is now recognised as a major underlying catalyst for hair loss and premature hair graying.

Here are a few things worth knowing.
Thread🧵


*Standard disclaimer that this does not constitute medical advice*

Oxidative stress is characterized by the overproduction of reactive oxygen species (ROS), which can induce mitochondrial DNA mutations, damage the mitochondrial respiratory chain, alter membrane permeability, and influence Ca2+ homeostasis and mitochondrial defense systems.

Calcium homeostasis refers to the maintenance of a constant concentration of calcium ions in the extracellular fluid.

It includes all of the processes that contribute to maintaining calcium at its “set point.”

Because plasma [Ca2+] rapidly equilibrates with the extracellular fluid, ECF [Ca2+] is kept constant by keeping the plasma [Ca2+] constant.

Insulin resistance can severely exacerbate hair loss and even trigger it in susceptible individuals.

There's up to a 68% increased risk of severe central scalp hair loss with type 2 diabetes.

But it's no wonder why:
-Chronically elevated blood sugar causes damage to the microvasculature (small blood vessels) of the scalp.
-Diabetic hyperglycemia frequently induces mitochondrial dysfunction and an overproduction of reactive oxygen species (ROS), which can trigger premature cell death in hair follicle stem cells.

Despite these facts, if you have T2D, there are some things you can keep in mind to help restore balance.

Thread🧵 *Standard disclaimer that nothing in this thread should be used as a substitute for medical advice*

It's George.

Insulin resistance is a condition where the body's cells become less responsive (aka “resistant”) to insulin.

Now insulin is produced in pancreatic β-cells in the islets of Langerhans and enables cells, particularly in muscles, fat tissue and the liver, to absorb glucose from the bloodstream for energy or storage.

When glucose levels drop for example, the pancreas releases glucagon, which signals the liver to release stored glucose (glycogenolysis) or produce new glucose (gluconeogenesis).

Recent research strongly links hair loss to mitochondrial dysfunction.

This obviously makes sense since hair follicles, being some of the fastest-dividing cells in the body, require massive amounts of ATP.

So when mitochondrial dysfunction is present, the energy supply plummets, triggering cellular stress and hair follicle degeneration.

Here are a few things that might help.
Thread🧵 *Standard disclaimer that nothing in this thread should be used as a substitute for medical advice*

It's George.

Overall, mitochondrial dysfunction is implicated in a host of health conditions ranging from chronic fatigue, low testosterone, depression, bipolar disorders and neurodegenerative diseases all the way to cardiovascular issues, diabetes and even sleep apnea.

So in general, if you enhance your mitochondrial function, your health will most likely improve.

An extremely neglected aspect of hair growth/slowing down hair loss is monitoring inflammation.

Here's what you need to know.
Thread🧵

It's George.

Monitoring inflammation is usually neglected because hair loss is traditionally treated only as a hormonal or genetic issue.

Follicle inflammation happens deep under the skin and often develops silently without visible surface signs.

But this chronic condition directly attacks hair stem cells, permanently stopping the creation of new strands.

It also causes micro-scarring around the root, choking out the vital nutrients the follicle needs.

Furthermore, the body diverts its cellular energy toward fighting inflammation instead of fueling new hair growth.

Ultimately, internal inflammation acts as an accelerator, triggering hereditary pattern baldness much earlier in life.

Always remember that the kynurenine pathway is crucial in autoimmune diseases.

So it's also crucial for alopecia aerata.

A highly active immune system triggers the enzyme indoleamine 2,3-dioxygenase (IDO), which drives the breakdown of tryptophan into kynurenine metabolites.

Normally, healthy hair follicles possess "immune privilege," meaning they are shielded from immune system attacks.

In conditions like alopecia areata, the dysregulated kynurenine-AhR (aryl hydrocarbon receptor) axis compromises this shield, allowing immune cells (like T-cells) to attack the follicle.

Now in case you have zero clue what the kynurenine pathway is, here's a qucik thread. The kynurenine pathway is the main metabolic route for breaking down tryptophan, accounting for about 95% of its catabolism (the rest goes to serotonin/melatonin or minor indole pathways).

You might think that this sounds extremely boring, but what if i told you that this pathway is so important that ketamine’s rapid antidepressant effects in treatment-resistant depression are greatly linked to its influence on the kynurenine pathway (the references are presented at the end as always)?

It produces a series of intermediate metabolites collectively called kynurenines with diverse biological effects (some are neuroprotective/anti-inflammatory, while others are neurotoxic/pro-inflammatory), with the end goal being the de novo production of nicotinamide adenine dinucleotide (NAD+).

Yeah, looking at screens as a dude makes you gay.
Here's why 👇

Several neurotransmitters and neuropeptides regulate erections in the penile tissue but also the central nervous system.

Neurotransmitters are chemical messengers released by neurons at synapses.

They directly excite or inhibit the target cell (whether that’s another neuron, a muscle or a gland) by binding to receptors and triggering rapid responses (within milliseconds).

So a neurotransmitter can excite the neuron, inhibit a message or adjust the communication at the synapse.

Now neuromodulators are a bit different as they are not restricted to the synaptic cleft between two neurons, and so can affect large numbers of neurons at once.

Neuromodulators therefore regulate populations of neurons, while also operating over a slower time course than excitatory and inhibitory transmitters.

Some molecules (like nitric oxide or certain peptides) can act as both, depending on context.

These (neurotransmitters and neuromodulators) operate at two levels:

Central (brain and spinal cord): Initiating psychogenic/nocturnal erections via arousal, motivation and autonomic control.

Peripheral (penile tissues): Executing tumescence by relaxing/contracting smooth muscle in the corpora cavernosa.

Psychogenic erections (from thoughts, sights, fantasies) and nocturnal ones involve the limbic system (amygdala, hypothalamus like paraventricular nucleus/PVN and medial preoptic area/MPOA) descending to spinal centers.

Now the pro-erectile (facilitatory) ones include:
Dopamine
Oxytocin
Nitric oxide (NO)
Glutamate
Vasoactive intestinal polypeptide (VIP)
Acetylcholine

The anti-erectile or mixed (inhibitory) ones include:
Serotonin (5-HT)
Noradrenaline
GABA
Opioids
Endocannabinoids
Endothelin-1
Prolactin

The most common “combination” in ED for example is low dopamine + oxytocin that leads to reduced psychogenic drive and excess serotonin/prolactin that inhibits arousal.

https://x.com/Helios_Movement/status/2063882216728334373

Let’s start with dopamine (DA).

Dopamine is arguably the most important central neurotransmitter for facilitating sexual motivation, arousal, and penile erection.

It is synthesized from phenylalanine and tyrosine with the help of phenylalanine hydroxylase and tyrosine hydroxylase.

The steps are:

L-Phenylalanine → L-Tyrosine.

This conversion is catalyzed by phenylalanine hydroxylase (PAH), primarily in the liver. PAH uses tetrahydrobiopterin (BH₄ (see previous parts on this series)) as a cofactor and adds a hydroxyl group to phenylalanine.

Phenylalanine is an essential amino acid (must come from diet), while tyrosine is conditionally essential (can be synthesized from phenylalanine or obtained directly from diet/proteins).

L-Tyrosine → L-DOPA (L-3,4-dihydroxyphenylalanine).
This is the rate-limiting step, catalyzed by tyrosine hydroxylase (TH) in dopaminergic neurons (e.g., in the brain and adrenal medulla).

TH also requires BH₄, oxygen, and iron (Fe²⁺) as cofactors.

TH is highly regulated (by feedback inhibition from dopamine and phosphorylation for example).

L-DOPA → Dopamine.

Catalyzed by aromatic L-amino acid decarboxylase (AADC, also called DOPA decarboxylase), using pyridoxal phosphate as a cofactor.

Now dopamine is involved in motor control, the reinforcement of certain behaviors through reward, motivation, learning, concentration and sleep but when it comes to erections, it acts primarily in the brain to integrate psychogenic and reflexogenic stimuli, bridging libido with the consummatory phase (actual erection and copulation).

Unlike peripheral mechanisms such as NO-cGMP in penile tissue, dopamine’s effects are predominantly central, with key actions in hypothalamic and limbic areas.

It influences erection through three main systems:

Incertohypothalamic system: Dopaminergic neurons from the A11-A14 groups project to the medial preoptic area (MPOA) and paraventricular nucleus (PVN) of the hypothalamus (the primary sites for pro-erectile DA action).

Mesolimbic system: From ventral tegmental area (VTA) to nucleus accumbens (drives sexual motivation/reward).

Nigrostriatal system: More for motor coordination during copulation.

In the PVN, DA activates oxytocinergic neurons projecting to the spinal cord (thoracolumbar and sacral levels), triggering parasympathetic outflow for erection.
The core pathway in the PVN are the following:

DA binds to receptors → increases intracellular Ca²⁺.

Activates neuronal nitric oxide synthase (nNOS) → produces NO.

NO (via cGMP-independent mechanisms, e.g., protein nitrosylation) activates oxytocinergic neurons

Oxytocin release in spinal cord → pro-erectile parasympathetic signals → penile smooth muscle relaxation and tumescence.

This loop links DA to central NO and oxytocin, explaining why DA agonists induce erections even with NOS inhibitors peripherally.

Non-selective agonists like apomorphine for example, induce erections within 10-25 minutes (sublingually).

When it comes to the dopamine receptors we have 5 (D1, D2, D3, D4, D5 and potentially a D6 (some of the recent literature includes the D6 and some does not)).

They divide into D1-like (D1, D5: stimulate adenylate cyclase) and D2-like (D2, D3, D4: inhibit it).

Pro-erectile effects are mainly via D2-like receptors in the PVN.

Now, when it comes to supporting dopamine production and its receptors in general, the first things you have to do are to:

Provide bioavailable protein, retinol, zinc, P5P, B9, vitamin C, vitamin K, vitamin D and vitamin E.

Avoid overstimulation (D2 receptors specifically are susceptible to downregulation from overstimulation (this is why meditation is shown to increase their density)).

Get some sun and avoid too much artificial blue light since in some animal models its shown to lead to an up to 30% reduction of tyrosine hydroxylase-positive neurons in the substantia nigra.

Monitor stress and relax.

Don’t live a sedentary lifestyle (we are meant to move thought the day which is why even 10 minutes of exercise can increase the density of the D2 and D3 receptors in some cases).

If you can go and measure your prolactin, insulin and androgens (testosterone for example upregulates dopamine (DA) pathways, particularly in brain regions like the nigrostriatal system).

9 of my favourite cheap, studied and easily accessible supplements when it comes to better mental health.

Thread🧵 It’s George.

No matter who you are, at some point, you will probably struggle with a "light" mental health issue, whether that's called minor depression, anxiety and so on.

This is totally normal since, in this day and age, we face the following conditions that create the perfect storm for them:

-Everyone grew up in a less-than-ideal environment.

No matter how loving or well-intentioned someone’s parents or caregivers were, the upbringing everyone receives is almost always imbalanced in one way or another.

This is totally normal and this imbalance tends to create both vulnerabilities and strengths.

It’s just that you’ll always be aware of your weaknesses, but you’ll have to discover your strengths.

As a side note, a very foolish attempt to engineer a “perfect” childhood will simply produce a fragile individual rather than a resilient human being with normal flaws.

Paradoxically, some degree of overcorrection is itself a natural part of psychological development.

-Most of the structure of modern life is profoundly unnatural both for our biology but for our minds as well.

From the fact that you can no longer operate at a basic human level and have to master 90 different things just to survive, to overstimulation, constant noise 24/7, high caloric malnutrition, isolation, chronic stress, material overconsumption and the fact that you have to sit in a chair for hours on end, all these create an environment our nervous systems were never designed to handle.

Almost everyone these days (even seemingly fit people) seems to have the combination of:
-High LDL
-Low HDL
-High blood pressure
-High triglycerides

Now, even if one of these markers in isolation might not be as problematic as it is advertised, this combination is in fact quite problematic.

So here's how you can start managing it.
Thread 🧵


First and foremost, let's start by breaking down cholesterol to a basic degree.

As we’ve said multiple times, cholesterol is a 27-carbon steroid alcohol with the systematic name cholest-5-en-3β-ol.

It has four fused rings (A, B, C, D), a hydroxyl group on carbon 3, a double bond between carbons 5 and 6, methyl groups on carbons 10 and 13, and an eight-carbon iso-octyl side chain on carbon 17.

Every animal on Earth needs it.
Plants, fungi and bacteria make zero cholesterol.

Your liver alone synthesises 800–1,200 mg daily even if you eat none, because every single one of your 37 trillion cells requires it for survival.

Revealing the root causes of hair loss (with actual proof).

An entire guide on understanding the common myths, realities, the real root causes and what to do about them.

Thread🧵
It’s George.

First and foremost, losing some hair as the years go by is normal.

We can't look at 70 like we did at 25 and believe it or not this is not common sense these days and the demands to avoid any sign of "ageing" are at an all time high because anything that can cause a negative emotion, is avoided and masked like the plague.

So, some hair loss if you are older, is fine.

BUT, younger and younger people are losing their hair and in A LOT of the cases, no one in the family had a history of premature hair loss.

So, if you just recently started noticing your hair falling off a bit, immediately address these because you might as well stop it within even a couple of months compared to the daily effort you'll have to put forever if you let it get worse and worse.

Now this thread will basically provide you with the MOST effective strategies you can use to manage premature hair loss.

If you find it helpful, make sure to leave a like.

SIBO is surprisingly common these days.

Yet it goes unrecognized quite frequently, even though it’s a common driver behind issues such as:
-Chronic fatigue
-Brain fog
-Skin issues
-Hormonal imbalances
-Autoimmune conditions
-Mental issues such as generalized anxiety and depression
-Systemic inflammation

If you still think that SIBO can't be one of the primary drivers behind your health issues, think again since:
-At least half of the people who’ve used PPIs or antibiotics have it.
-Most people who eat the S.A.D have it.
-Up to 78% of people an IBS diagnosis actually just have SIBO.
-Sibo is present in up to 50% of hypothyroid patients.
and there's more as you will see in this thread.

So without further ado, here’s the ultimate guide for conquering SIBO 🧵 *Standard disclaimer that nothing in this thread should be used as a substitute for medical advice*

It's George.
Let's start with the basics.

SIBO or small intestinal bacterial overgrowth is a well, almost a self-explanatory condition that marks an abundance of bad bacteria, such as the ones belonging to the firmicutes, bacteroidetes or proteobacteria phyla families overgrow in the small intestine.

The problem with this is that the small intestine and its parts, such as the duodenum, jejunum and ileum, are designed for nutrient breakdown and absorption, not bacterial fermentation.

Normally, it hosts fewer than 10^3 colony-forming units (CFU) per mL of bacteria, compared to 10^9–10^12 CFU/mL in the colon.

When this balance is disrupted, bacteria ferment carbohydrates for example, producing gases like hydrogen, methane or hydrogen sulfide.

These can drive symptoms such as bloating, abdominal pain and altered bowel movements (diarrhea, constipation and so on).

But SIBO is not just a gut issue.
It has systemic effects, including nutrient deficiencies, systemic inflammation and neurological symptoms for example.

The thyroid gland affects more processes than we could imagine and its dysfunction could lead to severe fatigue, hair loss, SIBO, high LDL, impaired detoxification, low levels of DHT and more.

So here's a thread on some things worth knowing when it comes to the thyroid gland🧵 It's George.

Most people still don't truly understand the impact of thyroid dysfunction.

The thyroid gland directly communicates with the brain, the pituitary, the parathyroid, the pancreas, the liver, the adrenal glands, the intestinal system and much more.

You already know this to be true if you are suffering from any type of thyroid dysfunction but here's an example i always try to mention.

Let's suppose that you want to lose weight, well in order to put in perspective how much the thyroid gland affects our metabolism, resistance training which is promoted as one of the best tools to increase BMR, can only lead to a 10% increase (which is still great).

Now here's what's fascinating, untreated hypothyroidism can lead to a BMR that's even 40% below normal and an even 50mcg of T3 day can increase BMR by even 30% in some cases.

You can also look into for example how T3 influences the tight junctions, how it upregulates the LDL-receptor, how it helps with the release of bile or even how it facilitates the production of lactase in the intestinal tract so thyroid dysfunction could even make you react badly to dairy.

In some studies, up to 90.5% of depressed people have subnormal T3 levels.

Even though more and more people are developing acne, it's not a mysterious disease that you can't do anything about.

Here's the most basic and effective roadmap for beating acne.

Thread 🧵

*Standard disclaimer that nothing in this thread should be used as a substitute for medical advice*

First and foremost and i am fully aware that plenty of you will dislike this suggestion, the first thing you should do if you have any issue related to your appearance such as acne, eczema or even if your hair has started thinning or you’re overweight, is to accept it.

After all, all of us will end up looking like raisins at 80, 90+ but i’m not seeing any sane old person become depressed about it.

Yeah, yeah, our appearances matter.

But not accepting something we have and can probably change is giving it too much power.

“How can i tell if my gut is the primary contributor behind my health issues?”

Well, here are the top (and often overlooked) warning signs your gut is out of balance.

Thread 🧵 *Standard disclaimer that nothing in this thread should be used as a substitute for medical advice*

It's George.

Numerous symptoms associated with compromised gut health manifest outside the gastrointestinal tract and these "extra-intestinal" manifestations can complicate conventional diagnosis, as standard medical evaluations may not immediately connect issues like mood changes or autoimmune flares to intestinal function.

But it’s no wonder that the integrity of the human gut microbiota correlates with susceptibility and outcomes of various diseases, including metabolic, infectious and autoimmune diseases.

The gut has a profound influence on every major organ and hormonal pathway in our bodies, whether that’s through bidirectional communication pathways aka “axes” (gut-brain axis, gut-liver axis, gut-immune axis etc), microbial metabolites, immune signaling, nutrient absorption and so on.

This is long, but it's the ultimate framework to get rid of a candida overgrowth.

You see, more people than ever are struggling with candida overgrowths and suffering from symptoms such as:

-Kidney problems.
-Intense sugar cravings.
-Skin issues.
-Digestive issues such as bloating, constipation, white coating on the tongue or gas (especially after eating carbs).
-Developing more and more food intolerances. -Brain fog
-Blood sugar regulation issues.
-Athlete’s foot, toenail fungus, jock itch, oral thrush, bad breath, acne and eczema.
-Chronic fatigue.
-Frequent infections.
-Leaky gut.

and much more as a consequence.

Yet most of them never truly resolve it and it's no wonder why.

Most people use the wrong supplements, neglect key mechanisms that keep candida in check by default and in general, follow highly ineffective roadmaps.

So here’s the BEST approach that can actually help you manage a candida overgrowth.

We will discuss:

-Common signs of candida overgrowth
-Tests you can take
-What Candida even is
-The most common causes in order to finally determine the main ones that are driving your overgrowth
-How to address each one in the most efficient way possible
-Common mistakes to avoid
-Breakdown of the most helpful supplements in this journey

and more.

Tap in.
Thread🧵


*Standard disclaimer that nothing in this thread should be used as a substitute for medical advice*

It's George.

First, some potential signs and symptoms of Candida overgrowth include:
-Digestive issues such as bloating, constipation, white coating on the tongue or gas (especially after eating carbs).
-Brain fog that, even though it might sound weird, it’s very similar to a low-grade hangover (since it releases acetaldehyde) which is experienced once again, especially after eating carbs.
-Blood sugar regulation issues.
-Intense sugar cravings.
-Athlete’s foot, toenail fungus, jock itch, oral thrush, bad breath, acne and eczema.
-Chronic fatigue.
-Frequent infections.
-Leaky gut.
-Developing more and more food intolerances.

Now, how can a candida overgrowth lead to these symptoms?

Here are some basic explanations.

First, it disrupts the balance of gut microbiota, reducing beneficial bacteria.

This leads to fermentation of undigested carbohydrates, producing gas and bloating by 2–3-fold as most studies suggest.

It also secretes aspartyl proteases and phospholipases, damaging the mucosal bilayer which can lead to bloating and general discomfort.

When it comes to the oral cavity, it forms biofilms creating a white coating on the tongue.

Then, it metabolizes sugars via fermentation, producing acetaldehyde, a toxic byproduct that crosses the blood-brain barrier and impairs neuronal function, causing brain fog, confusion, and a “hangover-like” feeling.

In animal models for example, candida-induced inflammation reduced cognitive clarity by 30%. Candida also consumes glucose for growth and biofilm formation, causing fluctuations in blood sugar levels, especially after high-carb meals.

In diabetic patients for example, an ovegrowth led to a 2-fold increase in insulin resistance.

Regarding sugar cravings, candida albicans thrives on glucose and its overgrowth may signal the host to consume more sugars throygh gut-brain axis modulation of hormones that control our appetite such as ghrelin.

Many studies show that a Candida overgrowth increased sugar cravings and ghrelin levels in 20–30% of patients.

Fatigue-wise, candida overgrowth triggers cytokines such as IL-6 and TNF-α, causing systemic inflammation that disrupts energy metabolism, the acetaldehyde impairs mitochondrial function, reducing ATP production, biofilms and mucosal damage impair nutrient absorption (especially when it comes to B vitamins and iron), which are critical for energy production.

Then, candida overgrowth overwhelms mucosal immunity, reducing IgA and phagocytic activity, increasing susceptibility to bacterial and fungal infections.

And finally when it comes to effects such as developing a leaky gut and food intolerances, the overgrowth degrades tight junction proteins such as occludin and ZO-1 (it’s shown to reduce ZO-1 expression by 40%), increasing intestinal permeability allowing toxins and antigens to leak into the bloodstream triggering immune responses and food intolerances (Candida-induced leaky gut has shown to lead to a 30% increase in food intolerances).

CoQ10 is not only important for people who use statins.

In fact, it might be the molecule that will improve your mood, cardiovascular health, energy levels, hormonal health and even liver health.

Here's why.
Thread🧵 It’s George.

CoQ10 depletion is linked to mitochondrial supercomplex destabilization, ceramide accumulation effects on ETC stability, and conditions like insulin resistance, CVD, Graves, inflammatory disorders, post-viral fatigue, the fast progression of liver disease, muscle weakness, exercise intolerance, cramps, myalgia, elevated creatine kinase (CK) and much more.

Now coenzyme Q10 aka CoQ10, is a fat-soluble, vitamin-like molecule (*) that’s naturally present in every cell membrane throughout the body.

(*) An organic compound that supports bodily functions like vitamins K and E, but isn't classified as a true vitamin because the body can often synthesize it. Another example is carnitine.