Most people don't get enough minerals and this could be one of the main drivers behind common problems such as fatigue, acne, low testosterone, gut issues, hormonal issues, a compromised immune system low libido and more.

Here's what to do about it.
Thread🧵 Minerals are needed for almost every process inside of our bodies and if we neglect their importance, we can not expect to be healthy.

● Tens of housands of enzymatic reactions
● Regulating our nervous system
● Detoxification
● Energy production
● Blood cell production
● Oxygen metabolism
● The utilization of vitamins
● Adrenal health
● Blood sugar regulation
● Thyroid health
● Gut health (HCL, antimicrobial and digestive enzyme production)
● Battling oxidative stress
● Immune function
● Hormone synthesis
● Cellular hydration of cells (controlling fluids inside and outside cells)
● Bone health
● Skin health
● Joint health
● Hair health
● Heart health
● Brain health
and a lot more.

This is why for example low calcium levels can cause muscle spasms, low magnesium levels can cause muscle cramps and even cardiac arrhythmias, a zinc deficiency can cause gut issues, low libido and skin issues, an iodine deficiency can case goiters and a copper deficiency can cause low white blood cell count or even premature gray hair (copper helps the body produce melanin and a copper deficiency is associated with reduced SOD activity).

Classic studies that showcase some of these are the following in case you are interested in them (tap in the pics):

It takes approximately 380,000–400,000 IU of vitamin D3 (cholecalciferol) to reach the oral LD50 (50% lethality) in a typical half-pound rat.

Translating this to a human-equivalent dose (HED) we have 19 million IU.

Not thousands, not tens of thousands, but millions.

Ideally you want a vitamin D lamp in case the UVB index is low where you live but supplements are NOT entirely useless.

To understand how true this is, we will take a niche example of autoimmune diseases🧵

https://x.com/Helios_Movement/status/2044120250237759621

Now first and foremost vitamin D is a secosteroid (a type of steroid with a “broken” ring (it has a rupture in the 9,10 carbon-carbon bond of the “B” ring)) and prohormone (a substance that is a precursor to an active hormone) which is metabolized in various tissues to the active vitamin D hormone 1,25(OH)2D3 /calcitriol/1,25-dihydroxyvitamin d3.

It is not only involved in bone remodeling, through the regulation of calcium reabsorption from bone and the intestine, but it also regulates approximately 1000+ genes based on some research (*) in the human body through its active metabolite, influencing cellular differentiation and proliferation, immune system regulation, neural function, the cardiovascular system, and much more.

(*)After all, vitamin D receptors have been found to modulate the transcription of about 3% of human genes.

Now let’s move on to how we obtain this precious molecule.

Here's how to start managing your lipids (LDL, HDL, triglycerides etc) and blood pressure.

Thread 🧵


First and foremost, as we’ve said multiple times, cholesterol is a 27-carbon steroid alcohol with the systematic name cholest-5-en-3β-ol.

It has four fused rings (A, B, C, D), a hydroxyl group on carbon 3, a double bond between carbons 5 and 6, methyl groups on carbons 10 and 13, and an eight-carbon iso-octyl side chain on carbon 17.

Every animal on Earth needs it. Plants, fungi and bacteria make zero cholesterol.

Your liver alone synthesises 800–1,200 mg daily even if you eat none, because every single one of your 37 trillion cells requires it for survival.

Most men today, even the young ones, suffer not only from low testosterone but from low androgens overall.

This will inevitably lead to consequences such as:
-Low libido
-Fatigue
-Depression
-Anxiety
-Poor functioning memory
-Inability to put on muscle mass
-Lack of strength
and much more.

Of course, if you've personally experienced low androgens, you are familiar with these and already know how much it sucks.

It's literally hell on earth for a man.

So here's a guide that discusses:
-What androgens are
-How they are produced
-The main functions of each one
-Tests you can take
-How to improve their function
and more.

I guarantee that this will be the best thread on androgens you've ever read🧵
*Standard disclaimer that nothing in this thread should be used as a substitute for medical advice*

It's George.

First and foremost, when we are talking about androgens, we are referring to the following steroid hormones:

-Testosterone
-DHT
-DHEA
-DHEA-S
-Androstenedione
-Androsterone

Mold and mycotoxins are some of the primary drivers behind health issues such as:

-Chronic fatigue
-Fibromyalgia
-Insomnia
-Histamine intolerance/MCAS
-Dysfunctions of the immune system
-Skin issues
-nnEMF sensitivity
-Neuroinflammation
-Pathogen overgrowths
and more.

So here's a basic plan for dealing with this issue.
Thread 🧵
*Standard disclaimer that nothing in this thread should be used as a substitute for medical advice*.

It's George.

First and foremost, we are all exposed to various kinds of mold.

We are concerned with certain types that release mycotoxins such as:

-Aflatoxins such as aflatoxin B1 that are produced by Aspergillus species.

-Ochratoxins such as ochratoxin A that is produced by Aspergillus and Penicillium sp.

-Trichothecenes that encompass about 100 subtypes of metabolites from Fusarium species.

-Zearalenone that is produced by Fusarium species.

-Fumonisins that are metabolites produced by Fusarium species.

-Ergotamine / Ergot alkaloids that are compounds created by Claviceps species.

that can cause anything from cancer, infertility, G.I issues, MCAs, kidney disease all the way to mitochondrial dysfunction (fatigue to put it simply) and eczema once they are:

1. Ingested (most common route of exposure)

2.Inhalated

3. Or contacted with the skin

Even though red light therapy can revolutionize treating conditions such as:
-Chronic fatigue
-Hair loss
-Hormonal issues
-CVD
-Vision loss
-Tinnitus
-Skin issues
and more.

There are A LOT of misconceptions surrounding it.

So here's a breakdown on red light therapy if you want to maximize its benefits, minimize the downsides and save yourself money (backed up by plenty of studies of course).

Thread🧵


*Standard disclaimer that nothing in this thread should be used as a substitute for medical advice*

Red Light Therapy (RLT) is a subpart of phototherapy.

Phototherapy basically is the use of light for therapeutic purposes and is based on the interaction of light with biological tissues.

Phototherapy relies on the ability of specific molecules (such as chromophores) to absorb photons and activate biological processes (photobiomodulation (PBM), mitochondrial stimulation, cellular regeneration etc).

Here's your ultimate guide to conquering low libido (as a man).

Thread 🧵 It's George.

Erectile dysfunction is quite a common issue in this day and age, with up to 1 in 4 men under 40 struggling with it.

Yet, ED signals deeper issues and imbalances in things such as:

-The cardiovascular system
-Neurotransmitters
-Hormones
-Oxidative stress
-Lifestyle pitfalls

This is why it can even serve as an early biomarker for cardiovascular disease, because if the small helicine arteries cannot dilate due to endothelial dysfunction, the larger coronary arteries are likely next.

How to build a resilient immune system in a toxic world.
Thread🧵 It's George.

Modern life is quietly sabotaging everyone's immune system.

From spike protein pathology, redox collapse and thymic involution that shrink and starve your naive T-cell factory, all the way to heavy metal exposure, nutrient deficiencies, gut dysbiosis and much more, the list of things that harm our immune system is endless.

Now first and foremost, when we read the words “immune system”, it should be somewhat obvious that we are talking about a network of organs, tissues, special cells and so on that all work together instead of just “one thing”.

The main parts of the immune system are the:
● Bone marrow
● White blood cells
● Thymus
● Antibodies
● Complement system
● Lymphatic system
● Spleen
● Skin

Almost 40% of American adults have insulin resistance.

No, this number is not hyperbolic and it has consequences such as:

-Cardiovascular disease
-NAFLD
-PCOS
-Kidney disease
-Dementia
-Alzheimer’s disease
-Skin issues
-Chronic fatigue
-ED
and more.

So here's how to "hack" insulin (lifestyle interventions, tests, supplements etc).

Thread🧵 *Standard disclaimer that nothing in this thread should be used as a substitute for medical advice*

It's George.

Insulin resistance is a condition where the body's cells become less responsive (aka “resistant”) to insulin.

Now insulin is produced in pancreatic β-cells in the islets of Langerhans and enables cells, particularly in muscles, fat tissue and the liver, to absorb glucose from the bloodstream for energy or storage.

When glucose levels drop for example, the pancreas releases glucagon, which signals the liver to release stored glucose (glycogenolysis) or produce new glucose (gluconeogenesis).

How to feel like a human again.

A beginner's guide to beating anhedonia (lifestyle + biohacking).
Thread 🧵 It's George.

Anhedonia is derived from a Greek word that means "without pleasure".

It is not just "feeling down" or "not being in the mood" but a profound disruption in the brain’s reward processing system, affecting emotional and motivational responses that makes it a core symptom of several neurological and psychiatric disorders, including:

-Major depressive disorder (MDD)
-Bipolar disorders
-Schizophrenia
-Post-traumatic brain injuries (TBIs)
-Parkinson’s
-Alzheimer’s

but also implicated in conditions such as PSSD, post-finasteride syndrome and so on.

If you enhance your mitochondrial function, your health will most likely improve.

After all, mitochondrial dysfunction is implicated in a host of health conditions ranging from chronic fatigue, low testosterone, depression, bipolar disorders and neurodegenerative diseases all the way to cardiovascular issues, diabetes and even sleep apnea.

Here's how to power up your cells for better health.
Thread 🧵 It's George.

Have you ever wondered where you find the energy to do all the things you do in a single day?

What powers the beating of your heart, your thoughts, the movement of your arms and legs, your sight, smell, taste and hearing?

Because if you pause and really think about it, these are some quite demanding processes happening simultaneously.

Now, inside almost every single one of your cells, there are these “engines” called mitochondria that are responsible for some quite demanding jobs.

One of these is to produce the vast majority of a molecule that powers everything in your body.

That molecule is called ATP (adenosine triphosphate).

The “energy currency” of life, which unfortunately, we can’t store much of it so we need to constantly produce it.

To put in perspective just how much we need it, we produce 110–150 lbs in ATP every single day even at rest and at peak exercise intensity, production can spike to 0.5–1 kg of ATP per minute.

This miracle called ATP production is achieved through cellular respiration which is a fancy term that describes the process of converting the chemical energy stored in food into a usable form (ATP).

But cellular respiration doesn’t happen only in the mitochondria.

It starts outside them and then moves inside for the high-efficiency parts.

The cytoplasm handles the start.

The mitochondria handle the rest.

This neurotransmitter imbalance often drives certain types of hair loss, anxiety, eczema, gut issues, allergies, early morning insomnia (waking up at 3-4 A.M), ADHD and more.

Here's how to fix it.
Thread 🧵 It's George.

When you see topics such as:
-Type 1 allergic reactions
-ADHD
-Autoimmune diseases such as rheumatoid arthritis, systemic lupus erythematosus, long Covid, Celiac disease, multiple sclerosis, type 1 diabetes
anything related to innate immunity
-Psoriasis
-Hair loss
-Inflammatory bowel diseases
-Asthma
-Wound healing
-Nerve function
-Hematopoiesis
-Insomnia
-Migraines
-Vasodilation
-Vascular homeostasis
-Detection and elimination of pathogens
-Seasonal allergies
-Atherosclerotic plaque
-Food allergies
-Bone remodeling
-Eczema
-Or unfortunately even cancer

being mentioned, histamine intolerance and/or mast cells should immediately come to your mind.

For example, mast cells in scalp skin release histamine in response to stress or allergens, promoting inflammation (IL-1, TNF-α), vascular permeability and T-cell recruitment.

It’s demonstrated that the use of a simple antihistamine on the people who have AA and also atopic dermatitis (this is not uncommon with up to 40% of patients with AA having AD) greatly reversed their hair loss.

SIBO is surprisingly common these days.

Yet it goes unrecognized quite frequently, even though it’s a common driver behind issues such as:
-Chronic fatigue
-Brain fog
-Skin issues
-Hormonal imbalances
-Autoimmune conditions
-Mental issues such as generalized anxiety and depression
-Systemic inflammation

If you still think that SIBO can't be one of the primary drivers behind your health issues, think again since:
-At least half of the people who’ve used PPIs or antibiotics have it.
-Most people who eat the S.A.D have it.
-Up to 78% of people an IBS diagnosis actually just have SIBO.
-Sibo is present in up to 50% of hypothyroid patients.
and there's more as you will see in this thread.

So without further ado, here’s the ultimate guide for conquering SIBO 🧵 *Standard disclaimer that nothing in this thread should be used as a substitute for medical advice*

It's George.
Let's start with the basics.

SIBO or small intestinal bacterial overgrowth is a well, almost a self-explanatory condition that marks an abundance of bad bacteria, such as the ones belonging to the firmicutes, bacteroidetes or proteobacteria phyla families overgrow in the small intestine.

The problem with this is that the small intestine and its parts, such as the duodenum, jejunum and ileum, are designed for nutrient breakdown and absorption, not bacterial fermentation.

Normally, it hosts fewer than 10^3 colony-forming units (CFU) per mL of bacteria, compared to 10^9–10^12 CFU/mL in the colon.

When this balance is disrupted, bacteria ferment carbohydrates for example, producing gases like hydrogen, methane or hydrogen sulfide.

These can drive symptoms such as bloating, abdominal pain and altered bowel movements (diarrhea, constipation and so on).

But SIBO is not just a gut issue.
It has systemic effects, including nutrient deficiencies, systemic inflammation and neurological symptoms for example.

Autoimmune diseases are on the rise and they affect an estimated 5-10% of the global population.

If you happen to struggle with one, here are some of the best things you can do.

Thread 🧵 It’s George.

In autoimmune diseases, your own body is treated like an enemy.

As it was stated, they affect an estimated 5-10% of the global population, with most of them being more prevalent in women than men, except for type 1 diabetes and myocarditis.

The conservative estimates attribute greater than 75 percent of autoimmune disease incidence to women.

Why is that?

Well, there are a lot of reasons ranging from hormonal differences all the way to chromosome differences.

Estrogen in women for example, is known to cause B cells to produce a greater antibody and autoantibody response compared with men.

How, well some key mechanisms for this enhanced response include:

-Autoantibody production.

Estrogen promotes the survival and activation of autoreactive B cells that would typically be eliminated or rendered inactive. It is known to increase the numbers of CD5+ B cells producing autoantibodies.

-B Cell survival and activation.

Estrogen upregulates anti-apoptotic proteins like Bcl-2 in B cells, allowing them to escape programmed cell death (apoptosis) and survive longer, which contributes to increased autoantibody production, particularly in diseases like Systemic Lupus Erythematosus (SLE).

-Enhanced antibody production.

Estrogen enhances the differentiation of B cells into antibody-secreting plasma cells and increases the production of IgG and IgA. It also directly regulates the immunoglobulin heavy chain locus to increase antibody production.

-Genetic regulation.

Estrogen increases the expression of genes involved in B cell activation, such as CD22 and SHP-1, while also increasing activation-induced cytidine deaminase (AID), an enzyme critical for antibody class switching and somatic hypermutation.

-Increased inflammation.

Estrogen boosts the production of pro-inflammatory cytokines and simultaneously suppresses regulatory mechanisms that prevent immune overreaction, creating a more autoimmune-prone environment.

In Hashimoto’s for example, which is also more prevalent in women, most people seem to agree that:

-The genetic difference between XX and XY chromosomal configurations plays a critical role.

For example:

The X chromosome hosts a high concentration of immune-related genes, including crucial regulators like FOXP3, CD40L, and TLR7.

In females, one X chromosome is usually randomly inactivated in each cell to balance gene dosage with males. However, some immune genes escape this, leading to higher expression in females.

For example some studies show that 25–35% of women with the condition exhibit extreme skewing (>80:20), compared to only about 8% of healthy controls.

-Intense hormonal shifts such as:

Pregnancy/using birth control pills during puberty etc.

For example, a Danish study provided strong epidemiological evidence, showing that each son born to a mother increases her lifetime risk of developing Hashimoto’s by approximately 18%, which is wild and to be fair i don’t really know why.

Maybe it’s because in the third trimester, general immune suppression naturally occurs to protect the fetus.

Maybe it’s because postpartum, regulatory T-cells crash, causing an immune rebound.

Or maybe it’s something even more niche that i can’t even understand that includes cells transferred during pregnancy aka fetal microchimerism (during any pregnancy, a small number of cells from the developing fetus cross the placenta and enter the mother’s bloodstream which might also be why we find male cells in the thyroid tissue of 28–83% of women with Hashimoto’s).

Here's how to finally hack your ADHD (without doing meth).

Thread 🧵 It's George.

Everyone's attention spans are shorter than ever and even young, seemingly healthy people need the dopamine hit of conquering Sweden just to sit down and read one page from a book.

And they even make memes about it when in reality your brain is cooked and there's nothing funny about it.

"How can i tell if my gut is the primary contributor behind my health issues?"

Well, here are the top warning signs your gut is out of balance.

Thread 🧵 *Standard disclaimer that nothing in this thread should be used as a substitute for medical advice*

It's George.

Numerous symptoms associated with compromised gut health manifest outside the gastrointestinal tract and these "extra-intestinal" manifestations can complicate conventional diagnosis, as standard medical evaluations may not immediately connect issues like mood changes or autoimmune flares to intestinal function.

But it’s no wonder that the integrity of the human gut microbiota correlates with susceptibility and outcomes of various diseases, including metabolic, infectious and autoimmune diseases.

The gut has a profound influence on every major organ and hormonal pathway in our bodies, whether that’s through bidirectional communication pathways aka “axes” (gut-brain axis, gut-liver axis, gut-immune axis etc), microbial metabolites, immune signaling, nutrient absorption and so on.

Give me 3.5 minutes and i will give you the best peptide guide for beginners you've ever read.

Thread🧵 It's George.

Peptides can legitimately help with almost every goal people chase today:

-Extreme fat loss
-Improved memory recall, mood, mental clarity, focus etc
-Healing gut issues
-Healing common gym injuries
-Restoring libido and sexual function
-Rebuilding a broken immune system
-Slowing biological aging
And many more…

BUT, peptides are also one of the deepest, most confusing rabbit holes in modern health and performance.

So take 10 minutes to read this entire thing before you buy a single vial.

As stated, this is a beginner guide, so if you already know these and want to dive more in depth, go here: healthlibrary.substack.com

The power of herbs is severely downplayed to this day in most health spaces but this is a huge mistake.

So here's a thread on some powerful herbs that you should be aware of no matter if you struggle with hair loss, gut issues, low libido, anxiety, depression or insomnia🧵


*Standard disclaimer that nothing in this thread should be used as a substitute for medical advice*

Over the last years in the health space, the power of plants has been severely downplayed due to factors such as the recognition of the importance of animal foods but also the realization that tons of plants have a variety of built-in protection mechanisms that can harm humans (unless they are prepared right).

I am obviously not saying that plants are miracle cures or that you need them in order to thrive.

If you don't know how to prepare and use them right for example, some of them can even be contraceptives.

But that being said, there are certain plants which are very safe for most people and can be great supplemental tools.

Pay attention to the word “supplemental”.

I am not using the term “staple” and there’s a reason for it.

Plants are not meant to be used on a daily basis (all plants are seasonal after all) since past a certain point the chronic exposure to certain molecules in them can negatively affect things such as your thyroid or androgens for example.

For how long you should be using plants?

This depends on their potency and your starting point.

In general, things such as nettle root, rosemary, ginger, hibiscus, chamomile and saffron can be used multiple times per week, where others such as reishi, turkey tail, lion's mane and so on should be used once every week or two as a preventative measure and in other cases (let's say a TBI for example) they can be used daily for a few weeks.

Also, when it comes to all plants, quality matters, a lot.

You should NOT use the plants that will be mentioned unless you can get source them properly.

The last thing you want is to get some pesticide-filled plant and consume it thinking that it will benefit you.

Another thing you should keep in mind is that certain herbs are so effective, that can react negatively with certain medications whether they are blood thinners or whatever.

So contact your doctor or at least do some research before using one.

And finally, always remember that you can always add more, but, you can't take out. So when you are trying a new herb (or supplement in general) start with low doses the first time you try it.

Ideally 1/3 of the recommended. Yes, 1/3. If you don't have a negative reaction (most obviously won't) this advice can unironically be life saving.

Now let's get into the herbs.

L reuteri is missing in a lot of people (especially those who weren't breastfed (reason why you can literally give it to these children and they will cry less)).

Yet, the most popular strains can:
-Reverse some markers of ageing
-Inhibit inflammatory processes in the gut
-Make bones stronger
-Be quite helpful for oral candidiasis (in most species as well)
-Improve insulin resistance
-Increase testosterone
-Increase oxytocin
-Grow your balls
-Increase vitamin D levels, reduce LDL-C by 11.64% and apoB-100 by 8.41% relative to placebo

Downsides:
-Not ideal for people with MCAS
-Not ideal with people with hydrogen dominant SIBO

https://x.com/Helios_Movement/status/2017296630836342804

Multivitamins are a scam.

Here's how you can cover the vast majority of your micronutrient needs through delicious foods.

Thread 🧵


*Standard disclaimer that nothing in this thread should be used as a substitute for medical advice*

It's George.

First and foremost, let's see why multivitamins are a scam and why you should take your hard-earned money and purchase some real food instead.

For starters, realize that the claim for that multivitamins extend lifespan has been debunked for a long time and that you have higher chances of living longer if you are religious (not a joke).

Then, another big problem regarding this is that supplements overall, even though certain ones can be VERY helpful at times, lack transport proteins and all nutrients work synergistically.

For example:
-Selenium, sulfur, iodine, CoQ10, manganese, vitamin E, B2, iron.
-Thiamine, manganese and magnesium.
-B6 and B2.
-Zinc and copper.
-Retinol, DHA, E and B2.
-Vitamin K and retinol.
-Potassium and sodium.
-Choline and B9.
-B5 and K.
-Iron, B2, B12, B9 copper, D, retinol and C.
-Vitamin D, magnesium and retinol.
Etc

Jeremy Renner was run over by a 14,300-pound snowplough while trying to prevent it from hitting his nephew.

He was airlifted to the hospital, had more than 30 broken bones and yet somehow he has achieved a remarkable recovery.

This was partly possible thanks to peptides.
So here's the Avengers' peptide stack.

Thread🧵
It’s George.

Peptides can legitimately help with almost every goal people chase today:
-Extreme fat loss
-Improved memory recall, mood, mental clarity, focus etc
-Healing gut issues
-Healing common gym injuries
-Restoring libido and sexual function
-Rebuilding a broken immune system
-Slowing biological aging

And many more…

BUT, peptides are also one of the deepest, most confusing rabbit holes in modern health and performance.