High cortisol quite literally makes you dumb (shrinks your prefrontal cortex), fat, bald, tired, ruins your libido, thyroid and ages the crap out of you.

Here's what you need to know (from signs to look out for all the way to practical tips).

Thread🧵 *Standard disclaimer that nothing in this thread should be used as a substitute for medical advice*

It's George.

The adrenal glands, are two small triangle-shaped endocrine glands that sit on top of the kidneys.

They are broken down in the inner part (the adrenal medulla) and the outer region (the adrenal cortex, which is further broken down to the zona glomerulosa, zona fasciculata and zona reticularis).

Since they are endocrine glands, their main job is to produce hormones such as cortisol, aldosterone and adrenaline that are produced in response to stimuli from the pituitary gland (you can look up the hypothalamic pituitary adrenal axis or just corticotropin releasing hormones (CRH) and adrenocorticotropin hormone (ACTH)).

From anxiety, depression and insomnia all the way to the sad event of miscarriages, eczema and hair loss, a chronic health issue might be partly caused by SNPs in COMT and MTHFR that are getting quite popular these days.

But most advice regarding them is too complicated or too simplistic.

Here's the middle ground👇
Thread🧵
*Standard disclaimer that nothing in this thread should be used as a substitute for medical advice*

Let's start with the absolute basics:

1. An alkane, consists of hydrogen and carbon atoms (CnH2n+2) that are arranged like a tree.

2. An alkyl group, is an alkane missing one hydrogen.

Why does this matter regarding methylation?

Because:

-Methane, contains 1 carbon atom and 4 hydrogen atoms (CH4).

-A methyl group, is derived from methane and contains 1 carbon atom and 3 hydrogen atoms (CH3).

Now methylation is a form of alkylation where a methyl group is replacing a hydrogen atom.

Or as it is often referred to “the addition of a methyl group” (one carbon metabolism supplies methyl groups).

Most supplements over-promise and under-deliver.

Here are some supplements that don't and can actually help you in a variety of areas ranging from your brain and gut health all the way to your hormones and skin health.

Thread🧵
*Standard disclaimer that nothing in this thread should be used as a substitute for medical advice*

Note: This is about supplements indeed but if you do not get sunlight, exercise, eat whole foods, try to avoid vices such as excessive alcohol consumption and so on, then supplements will not save you.

Plenty of foods have more benefits that not only compared to the supplements at a low/medium price point but a very high as well. If a supplement, had the history and benefits of kefir for example, it would sell a lot. It’s just that you can only make so much profit from foods. I can’t sell you for example a $30 bottle of kefir yet i can very easily sell someone a $30 bottle of probiotics.

The right supplements CAN be useful and maybe even life saving. I am not dismissing them. At all. This is why we will talk about them.

This is just about having the right priorities.

Also, every single of these supplements that are mentioned will backfire for some people.

It's mathematically impossible not to.
If only 3.000 people read this and out of them 300 choose to use one, it's impossible for one of them to not react badly to it.

Does this fact make the supplement bad? No.
It makes it bad within a certain context.

So, read the studies that are linked.

Now let's talk about the supplements (not presented by order of importance).

Like most of the health problems that are abundant in today’s society, skin issues such as acne and eczema are something almost completely new.

Here's what you need to know.

Thread 🧵 *Standard disclaimer that nothing in this thread should be used as a substitute for medical advice*

It's George.

If you are struggling with a skin issues right now, you must understand the following:

It's a symptom, not the root cause.

Let's take acne for example.

If you only focus on the mix of hyperkeratinization, propionibacterium and so on that's usually (if not always) found in people with acne with topicals, you will only go so far.

What you should do instead?
Focus on the main root causes that contribute to skin issues.

Neglecting your sleep is the fastest way to become sick.

You can have the perfect diet, workout plan and so on, but if you don't get deep sleep on a regular basis you're doomed to fail.

So here's how you can get deep sleep on a regular basis.
Thread🧵
*Standard disclaimer that nothing in this thread should be used as a substitute for medical advice*

Now of course if you’ve been sleep deprived for an extended period of time you are already aware of the serious negative effects that it has on multiple areas of your health.

You get tired, sick very easily, your mental and physical performance take a big hit, your libido is non existent, have wild food cravings and so on.

In general, sleep deprivation will lead to:
-Fatigue
-Increased risk for cancer
-Immune system dysfunction
-Hormonal issues such as low testosterone, diabetes and impaired glucose tolerance and hypothyroidism
-Hypertension
-Vascular damage
-Mood swings
-Premature skin aging and other issues such as dark circles
-CVD
-Liver issues
and sleep deprivation will of course exacerbate all existing health issues.

Mold and mycotoxins are some of the primary drivers behind a lot of people's health issues.

Here are some basic things to consider.

Thread 🧵
*Standard disclaimer that nothing in this thread should be used as a substitute for medical advice*.

It's George.

First and foremost, we are all exposed to various kinds of mold.

Mold overall is not the issues, certain types that release mycotoxins such as:

-Aflatoxins such as aflatoxin B1 that are produced by Aspergillus species.

-Ochratoxins such as ochratoxin A that is produced by Aspergillus and Penicillium sp.

-Trichothecenes that encompass about 100 subtypes of metabolites from Fusarium species.

-Zearalenone that is produced by Fusarium species.

-Fumonisins that are metabolites produced by Fusarium species.

-Ergotamine / Ergot alkaloids that are compounds created by Claviceps species.

POMC 101 👇 (if you've been exposed to mold, have autoimmune issues, low libido or any hormonal issue and skin issue you need to know these)

POMC is a precursor polypeptide primarily produced in the pituitary gland, the skin and the hypothalamus.

I like to call it a “master precursor” even though it’s incorrect because it gets cleaved into crucial peptides like a-MSH, ACTH, CLIP, Gamma-MSH and beta-endorphin by enzymes like prohormone convertases (PC1/3 and PC2).

Its expression and upregulation is influenced by a variety of physiological, environmental and molecular factors one of them being: UV light exposure (especially UVB (280–320 nm)) that stimulates POMC expression in keratinocytes and melanocytes in the skin (up to 30% increase).

When UVB light penetrates the skin, it causes DNA damage in keratinocytes, activating the tumor suppressor protein p53 and UVA (320–400 nm) activates photoreceptors like neuropsin (OPN5) which further enhances POMC expression. Now when it comes to the key cleavage products of POMC we have:

1. Alpha-MSH (Melanocyte-Stimulating Hormone)

This one is expressed mainly in the hypothalamic arcuate nucleus and nucleus tractus solitarius of the brainstem and stimulates melanocytes to produce eumelanin, inhibits pro-inflammatory cytokines such as IL-6, TNF-alpha, improves our libido (melanotan I and II Synthetic analogs of α-MSH), regulates our appetite, and supports our immune system and brain.

A quick note in order to understand how important these are, is that low alpha-MSH levels are observed in 85% of autoimmune patients and 90% of mold-exposed patients.

2. ACTH (Adrenocorticotropic Hormone).
This one is produced and secreted by the anterior pituitary gland and stimulates the adrenal cortex through MC2R to produce and release cortisol (just like all hormones, cortisol follows a circadian pattern and should peak in the morning).

3. Beta-Endorphin
This is mainly produced in the pituitary gland and as an endogenous opioid, it plays a key role in pain relief and reward systems.

4. Gamma-MSH (gamma-Melanocyte-Stimulating Hormone).

This is produced in the pituitary gland that primarily acts on melanocortin receptors (especially MC3R) in the brain and peripheral tissues, regulates cardiovascular function, aldosterone production in the adrenal glands and inflammation.

5. CLIP (Corticotropin-Like Intermediate Peptide) This is also produced by the pituitary gland and modulates insulin secretion by affecting beta cells and it might have have neuromodulatory effects.

Ensuring proper levels of vitamin D is one of the most sure ways to:

-Improve thyroid function and metabolic health
-Prevent autoimmune diseases
-Prevent muscle waste
-Improve steroid-driven hair loss
-Treat fatigue
-Improve insulin resistance and type 2 diabetes
-Improve low testosterone
-Improve calcium absorption
-Support the immune system
-Fight allergies
-Improve skin conditions
and more.

Here's what you need to know.
Thread🧵
*Standard disclaimer that nothing in this thread should be used as a substitute for medical advice.

It's George.

Vitamin D is a hormone-like vitamin that controls about 3% of your entire genome (roughly 1,000 genes), is a cellular multitasker that affects everything from detoxing xenobiotics, insulin, leptin, testosterone, progesterone, skin health and gut health all the way to bone health, muscle building, heart health, brain health, our blood pressure, fertility and immunity.

If you want to successfully treat and prevent the occurrence of any health issue no matter if it's:

• Alzheimer’s
• A gut issue
• Eczema
• Tinnitus
• High blood pleasure
• Diabetes
• Low libido
• Hair loss
• And even unfortunately cancer
you need to truly understand what melatonin is and how to optimize its endogenous production.

Thread🧵

*Standard disclaimer that nothing in this thread should be used as a substitute for medical advice*

Melatonin, chemically known as N-acetyl-5-methoxytryptamine, is classified as an indoleamine that is derived from the amino acid tryptophan.

Now technically speaking, since it is synthesized in many non-endocrine organs and doesn't target a specific organ it’s not a hormone (Melatonin fits this in the pineal context only).

As you will see at the studies that are presented at the end of this, melatonin is crucial for our immune system, gut health, skin health, brain health and is even linked with erectile dysfunction.
.

You don’t have to spend hundreds of dollars on fancy supplements that don’t really work.

Here are ten dirt cheap supplements that can have a positive impact on your health and could be more effective than expensive ones.

Thread🧵
*Standard disclaimer that nothing in this thread should be used as a substitute for medical advice*

Note: This is about supplements indeed but if you do not get sunlight, exercise, eat whole foods, try to avoid vices such as excessive alcohol consumption and so on, then supplements will not save you.

Plenty of foods have more benefits that not only compared to the supplements at a low/medium price point but a very high as well. If a supplement, had the history and benefits of kefir for example, it would sell a lot. It’s just that you can only make so much profit from foods. I can’t sell you for example a $30 bottle of kefir yet i can very easily sell someone a $30 bottle of probiotics.

The right supplements CAN be useful and maybe even life saving. I am not dismissing them. At all. This is why we will talk about them.

This is just about having the right priorities.

Now let's talk about the supplements (not presented by order of importance).

Most people's livers are crying for help in the modern day and age (approximately 100–120 million Americans likely have liver issues as we speak).

So here's the most effective strategy for improving the health of your liver.

Thread🧵 Let's start with the boring but necessary basics.

The liver is the second-largest organ in your body which is located in the upper right-hand part of your abdominal cavity underneath your diaphragm, right lung and rib.

It is made up of two main lobes which are made up of thousands of tiny lobules and each is made up of numerous hepatocytes.

These line up and between each row there are small blood vessels that diffuse oxygen and nutrients called sinusoids.

We can divide liver lobules into 3 metabolic zones: zones 1, 2, and 3.

Zone I hepatocytes are specialized for functions such as cholesterol synthesis, b-oxidation of fatty acids, and gluconeogenesis.

Zone II are crucial for liver homeostasis.

Zone III are crucial for detoxifying based on cytochrome P-450, glycolysis and lipogenesis.
Now a portal triad/area/canal/tract or field, is an arrangement within lobules that consists of:

-The proper hepatic artery ( a branch of the hepatic artery) which supplies the left and right lobes of the liver (not only that but the gallbladder and a part of the stomach as well).

-The hepatic portal vein which carries blood from the pancreas, intestines, gallbladder and spleen to the liver. To the liver, not from the liver, the hepatic vein does this, not the hepatic portal vein.

-Bile ducts which are multiple thin tubes that go from the liver to the small intestine which carry bile from the liver and gallbladder, through the pancreas, and into the small intestine.

Now obviously there are more cell types that reside in the liver besides hepatocytes such as kupffer and endothelial cells.

So if you want to be healthy, you're going to need a healthy liver by default.

Before tanking your libido and mood with finasteride, you should know that PGD2 is elevated in balding areas.

What's "PGD2" you ask?
Here are the basics.

Thread🧵 PGE2 stands for "Prostaglandin D2" and is probably the most famous prostaglandin.

From hair loss, high blood pressure, hormonal issues such as low testosterone and cancer all the way to schizophrenia and depression, prostaglandins are involved in the occurrence of all of these.

This might seem too much, but prostaglandins are lipid mediators that affect processes varying from inflammation, uterine contraction and bronchoconstriction all the way to regulating blood flow and clotting.

PGE2 for example mediates inflammation, promotes vasodilation, increases vascular permeability, regulates immune responses such as even fever for example, causes relaxation or contraction of smooth muscles depending on the tissue, is involved in ovulation and fertilization, helps maintain the integrity of the gastric mucosa, helps with the regulation of sodium, stimulates both bone resorption and bone formation through osteoclasts and osteoblasts, it can inhibit certain T-cell functions and these don't even scratch the surface.

So it's quite important.

Here are the most effective strategies when it comes to avoiding sunburns.

Thread🧵 *Standard disclaimer that nothing in this thread should be used as a substitute for medical advice*

For starters i'd like to make something very clear for people who might think that we don't need sunlight and we can just use a vitamin D supplement and call it a day: We need to get full spectrum sunlight if we want to be healthy.

Lack of full spectrum sunlight has been proven as bad as smoking and will lead to insomnia, mitochondrial dysfunction (think fatigue for starters), gut issues, getting sick very often, low libido, hormonal issues and a lot more.

Heck, even molecules containing π-electrons and UV light work synergistically as you can see in the picture down below.

Sunlight is that important for our health.

But that being said, there's doing sunlight exposure the right way which will lead to improved skin health, gut health, sleep, hormonal health and a lot more, and also doing sunlight exposure the wrong way which will age the skin a lot, causes insomnia, stress and a lot more.

Here's a summary of the MOST effective strategies you can use to manage premature hair loss and gray hair that don't have dangerous side effects.

Master thread🧵

Disclaimer: The sooner you start implementing these once you notice these issues, the better your results will be.
*Standard disclaimer that nothing in this thread should be used as a substitute for medical advice*

First and foremost, losing some hair as the years go by is normal.

We can't look at 70 like we did at 25 and believe it or not this is not common sense these days and the demands to avoid any sign of "ageing" are at an all time high because anything that can cause a negative emotion, is avoided and masked like the plague.

So, some hair loss if you are older, is fine.

BUT, younger and younger people are losing their hair and in A LOT of the cases, no one in the family had a history of premature hair loss.

So, if you just recently started noticing your hair falling off a bit, immediately address these because you might as well stop it within even a couple of months compared to the daily effort you'll have to put forever if you let it get worse and worse.

From hair loss, hormonal issues such as low testosterone and cancer all the way to schizophrenia and depression, prostaglandins are involved in the occurrence of all of these.

Here's what you need to know.
Thread🧵 *Standard disclaimer that nothing in this thread should be used as a substitute for medical advice*.

It's George.

Now, the things that were stated in the title, might seem too much, but prostaglandins are lipid mediators that affect processes varying from inflammation, uterine contraction and bronchoconstriction all the way to regulating blood flow and clotting.

PGE2 for example which is just one of them, mediates inflammation, promotes vasodilation, increases vascular permeability, regulates immune responses such as even fever for example, causes relaxation or contraction of smooth muscles depending on the tissue, is involved in ovulation and fertilization, helps maintain the integrity of the gastric mucosa, stimulates both bone resorption and bone formation through osteoclasts and osteoblasts, it can inhibit certain T-cell functions and these don't even scratch the surface.

Most men try to improve their testosterone levels the wrong way.

Here's how to actually do it aka an in depth plan ranging from key lifestyle factors you must address all the way to the exact supplements that could be helpful.

Thread🧵 *Standard disclaimer that nothing in this thread should be used as a substitute for medical advice*

It's George.

Most men today, even the young ones, suffer from low testosterone and the common consequences that this has such as:

• Chronic fatigue
• Low libido
• Fertility issues
• Inability to put on muscle mass and lack of basic strength
• Depression
• Anxiety

Of course, if you've personally experienced low testosterone you are familiar with these and already know how much it sucks.

It's literally hell on earth for a man so let's talk about the things that could help out a person that's going through it.

Now of course if you don't believe that a holistic approach can have a positive impact on your hormones and you should just use exogenous hormones (something that i'm not against if certain lifestyle factors are addressed first) just look at the study in the pics below.

Most people in health spaces might pay attention to vitamins but arguably, minerals can be equally or even more important than them and not consuming nearly enough of them will lead to issues such as:

-Fatigue
-High blood pressure
-Gut discomfort
-Migraines
-Hormonal issues
-Mood swings such as anxiety
-Osteoporosis
-Acne
and more.

This isn't a joke (all of these claims are backed up inside of this) and minerals are that important for our overall health.

Here's the main function of each one and also how to start replenishing and balancing them out.

Thread🧵
*Standard disclaimer that nothing in this thread should be used as a substitute for medical advice*

It's George.

Minerals are needed for almost every process inside of our bodies and if we neglect their importance we can not expect to be healthy.

Minerals are needed for:
● Thousands of enzymatic reactions
● Regulating our nervous system
● Detoxification
● Energy production
● Blood cell production
● Oxygen metabolism
● The utilization of vitamins
● Adrenal health
● Blood sugar regulation
● Thyroid health
● Gut health (HCL, antimicrobial and digestive enzyme production)
● Battling oxidative stress
● Immune function
● Hormone synthesis
● Cellular hydration of cells (controlling fluids inside and outside cells)
● Bone health
● Skin health
● Joint health
● Hair health
● Heart health
● Brain health
and a lot more.

This is why for example low calcium levels can cause muscle spasms, low magnesium levels can cause muscle cramps and even cardiac arrhythmias, a zinc deficiency can cause gut issues, low libido and skin issues, an iodine deficiency can case goiters and a copper deficiency can cause low white blood cell count or even premature gray hair (copper helps the body produce melanin and a copper deficiency is associated with reduced SOD activity).

Classic studies that showcase some of these are the following in case you are interested in them:

sciencedirect.com/science/articl…
pubmed.ncbi.nlm.nih.gov/9523054/
ncbi.nlm.nih.gov/books/NBK50727…
researchgate.net/publication/22…
pmc.ncbi.nlm.nih.gov/articles/PMC90…
pubmed.ncbi.nlm.nih.gov/36577241/
faseb.onlinelibrary.wiley.com/doi/epdf/10.10…

Neglecting neurotransmitter health, is a very common reason when it comes to why plenty of people never improve a variety of issues such as:

-Anxiety
-Low libido
-Trouble focusing
-Depression
-Skin issues
-Gut issues

This is why i wrote the ultimate neurotransmitter thread that will provide you with some valuable knowledge you'd usually either have to pay for it or give 3-5 hours of your time.

Let's get into it🧵
*Standard disclaimer that nothing in this thread should be used as a substitute for medical advice*

Firstly, why is this subject even important?

Well, millions of motor, electrical and chemical signals need to go through various parts of our bodies at any given moment.

This is partly accomplished through membrane-to-membrane junctions.

Neurotransmitters are molecules that are used in order to send signals from neurons to muscles and glands or between neurons.

The surprising set of nutrients most people don't get enough of and experience:

-Fatigue
-Weight gain
-Heart problems
-Skin issues
-Hormonal issues
-A compromised immune system
and more, as a result.

Thread🧵


*Standard disclaimer that nothing in this thread should be used as a substitute for medical advice*

Before we even get into the nutrients, you MUST be aware of certain things that deplete us of various micronutrients, interfere with their absorption or increase the need for certain micronutrients:

1. Sweating
Nutrients it mainly depletes:
-Electrolytes but especially potassium

2.Alcohol Nutrients it mainly depletes:
-B vitamins
-Electrolytes
-Vitamin K

3. Sodium fluoride, bromine etc
Nutrients they mainly interfere with:
-Minerals and especially trace minerals

4. Smoking Nutrients it mainly depletes:
-Retinol
-Vitamin C
-Taurine

5. Phytic acid
Nutrients it mainly depletes:
-Minerals and especially zinc

6. Stimulants
Nutrients they mainly deplete:
-Vitamin C
-Electrolytes
-B1
-B2
-B5

7. Statins Nutrients they mainly deplete:
-CoQ10
-Vitamin D
-Vitamin A, K and E depending on the dosage

8. Birth control pills Nutrients they mainly deplete:
-Everything, just stop using them

9. Antidepressants Nutrients they mainly deplete:
-B vitamins
-Vitamin K
-Vitamin D

10. Blood pressure medication
Nutrients they mainly deplete:
-B vitamins
-Electrolytes

11. Stress
Nutrients it mainly depletes:
-Minerals
-B vitamins

12. Heavy metals
Nutrients they mainly deplete:
-Minerals

13. High protein diet
Increases the need for:
-Magnesium
-Biotin
-Molybdenum

14. High carb diet
Increases the need for:
-Thiamine
-Vitamin C
-Magnesium
-Potassium
-Zinc

15. Herbicides and pesticides.
These terms are too broad, but most of the trouble makers deplete/interfere with:
-Minerals
-Glycine
-Vitamin K

16. NAC/glutathione
Now don't freak out, NAC can be a useful supplement but it will mess up copper status and even zinc if it's used for months on end.

Same with things such as NAD+, niacin or NMN for example.

If you're going to use them for a long time you should encounter for their side effects and in this case add some TMG for example.

17. Binders such as activated charcoal.
Nutrients it mainly depletes/interferes with:
-Minerals

18. Elevated PTH
Nutrients it mainly interferes with:
-Calcium
-Magnesium

If you want more energy, better gut health, skin health, improved libido and so on, you must make sure that you avoid the following dietary mistakes.

Thread🧵


*Standard disclaimer that nothing in this thread should be used as a substitute for medical advice*

For starters, in case you are skeptical about just how much our diet matters, consider that tens of thousands (if not more) of DNA-related processes are based on nutrients.

So, when we deprive ourselves of nutrients (either by not providing enough of them OR by messing up their absorption), TENS OF THOUSANDS of DNA-related processes become dysfunctional.

That being said, now let's just right into common dietary mistakes (these might be numbered, but in the long run, all of these are equally important in my opinion).

Getting sick multiple times per year?
You probably don't have to.

But in order to accomplish that, you must become aware of:
-The main functions of the immune system and the root causes that lead to their dysfunction
-Crucial lifestyle factors that can support it
-Key foods, herbs and supplements that can support it

We will cover all of these here.
Thread🧵 *Standard disclaimer that nothing in this thread should be used as a substitute for medical advice*

Gm, it’s George.

Inside of this thread as stated, there will be some tips and tricks that can help you battle a cold or virus more effectively, but since we can’t rely on them if we’re being honest, we will have to also understand and improve the function of your immune system overall.

This way, we will both massively lower our chances of getting sick this winter but also increase the chances of a very fast recovery in case we do get sick.

Now let’s get into it.