Thread by @ejustin46

SARS-COV-2 and INTESTINAL DAMAGE
(Part 1)

2) At a time when we are talking a lot about peaks in wastewaters, we were interested in the relationships between SARS-COV-2 and the intestines. A brief overview of this topic through some visualisations and studies.
mdpi.com/2076-0817/10/8…

3) "Potential intestinal infection and faecal–oral transmission of SARS-CoV-2"
nature.com/articles/s4157…

3) Evidence of SARS-CoV-2 intestinal infection

4) "COVID‐19 induces gastrointestinal symptoms and affects patients’ prognosis"
journals.sagepub.com/doi/full/10.11…

5) Fig. The lung-gut axis in coronavirus disease

6) "Intestinal Damage in COVID-19: SARS-CoV-2 Infection and Intestinal Thrombosis"
frontiersin.org/articles/10.33…

7) Fig. Intestinal thrombosis leads to intestinal mucosal necrosis and dissemination of gut bacteria, endotoxins, and microbial metabolites in blood.

8) Fig. Phosphatidylserine exposure on activated/apoptotic cells and microparticles (MPs) promotes fibrin formation

9) ARTICLE : "TMPRSS2 and TMPRSS4 mediate SARS-CoV-2 infection of human small intestinal enterocytes"
prelights.biologists.com/highlights/tmp…

10) And to finish this last study, which is the most important and to which we will have the opportunity to return in the 2nd part :

Fig. TMPRSS2 and TMPRSS4 promote VSV-SARS-CoV-2 infection in enteroids. science.org/doi/10.1126/sc…

11) We will address also later the hypothesis of certain mutations, which play a key role in intestinal damage and which are found in certain new variants.
Thanks 🙏
FYI
@DavidJoffe64 @UseBy2022 @SolidEvidence @LongDesertTrain
@siamosolocani @RadCentrism @outbreakupdates