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Ziyad Al-Aly, MD Profile picture
@zalaly
Dec 24 • 4 tweets • 2 min read • Read on X
3 key messages from our recent paper in @TheLancetInfDis

1. Covid is worse than flu

Covid remains a much more serious threat to human health than the flu

thelancet.com/journals/lanin…
2. Comparing the two:

COVID is more multisystemic
Flu is more respiratory

thelancet.com/journals/lanin…
3. Both covid and flu cause more health loss in the long-term than what is evident around the time of the infection

Trivializing these illnesses as inconsequential ignores the large burden of health loss that occurs in the post-acute/chronic/long phase

thelancet.com/journals/lanin…
Get vaccinated for both covid and flu (& RSV if you qualify)

Reduce your risk of exposure: masking, outside activities less riskier than inside, ventilated space safer

Test if you have symptoms, & talk to your provider about antivirals if you test +

thelancet.com/journals/lanin…

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More from @zalaly

Ziyad Al-Aly, MD Profile picture
Dec 16
Some people objected to use of the term “long flu”

Let me explain

A thread

thelancet.com/journals/lanin…
Lets start with the evidence about health loss

higher in post-acute flu than acute flu

higher in post-acute covid (long covid) than acute covid

In both acute and post-acute phases, burden of health loss was higher in covid than flu

thelancet.com/journals/lanin…
For me, a big revelation from the study was:

the realization that when you measure it, the burden of health loss is higher in post-acute (long) phase of illness than acute phase of illness

I knew this about covid
I did not know this about flu
Read 10 tweets
Ziyad Al-Aly, MD Profile picture
Dec 14
📣 New from my team in @TheLancetInfDis

Long-term outcomes of people hospitalized for COVID-19 vs seasonal influenza

A 🧵

thelancet.com/journals/lanin…
The study included:

81,280 individuals hospitalized for SARS-CoV-2
&
10,985 individuals hospitalized for seasonal influenza

We followed them for 1.5 years to characterize the risks of death, health care utilization & 94 health outcomes

thelancet.com/journals/lanin…
Covid had higher risk of death, healthcare utilization and sequelae in most organ systems than flu

This was evident in pre-delta, delta, and omicron; and also evident in vaccinated and unvaccinated individuals.

thelancet.com/journals/lanin…

Image
Image
Read 9 tweets
Ziyad Al-Aly, MD Profile picture
Aug 21
1/ 📣 New from my team in @NatureMedicine

In a study of 6 million people, we examined risk trajectories of 80 components of Long Covid over 2 years post-infection

📌 Risks remained elevated for many Long Covid conditions even 2 years infection

A 🧵

nature.com/articles/s4159…
2/ The study included:

138,818 individuals with SARS-CoV-2
&
5,985,227 non-infected controls

We followed them for 2 years to characterize the risk trajectories of death, hospitalization and 80 components of Long Covid

nature.com/articles/s4159…
3/ In people who were not hospitalized during the acute phase of COVID (the majority)

risk of death remained elevated up to 6 months

risk of hospitalization remained elevated up to 19 months

risks remained elevated for 31% of sequelae during the 2-year

nature.com/articles/s4159…
Image
Read 22 tweets
Ziyad Al-Aly, MD Profile picture
May 10
My piece in @TheLancetInfDis

Reflections on Long Covid prevention: progress and challenges

A thread

thelancet.com/journals/lanin…
LongCovid does not only affect patients and their life expectancy, but also societal wellbeing and economic indicators (labour participation and economic productivity).

Preventing long COVID should be a public and a global health priority.

thelancet.com/journals/lanin…
All evidence points in the same direction—SARS-CoV-2 antivirals might be important tools for prevention of Long Covid

Paxlovid reduced the risk by 26%

Molnupiravir reduced the risk by 14%

Ensitrelvir may also reduce the risk

thelancet.com/journals/lanin…
Read 12 tweets
Ziyad Al-Aly, MD Profile picture
Apr 22
Here is a new thread on our latest study without the full C word - to avoid suppression by the algo

C=kovd

Is C still deadlier than the flu in 2023?

The short answer is yes

New from our team in @JAMA_current

By @Biostayan, Taeyoung Choi and @zalaly

jamanetwork.com/journals/jama/…
In this study of 11,399 people

8996 hospitalized for C & 2403 hospitalized for flu

5.9% died in the C group vs 3.7% died in the flu group

That is a difference of 2.23% deaths

This translates into 60% higher risk of death in C vs flu

jamanetwork.com/journals/jama/…
The 60% higher risk of death in people hospitalized for C vs flu should be interpreted in the context of 2-3 times more hospitalization for C than hospitalization for flu

This compounds the rates of death due to C vs flu

jamanetwork.com/journals/jama/…
Read 8 tweets
Ziyad Al-Aly, MD Profile picture
Apr 6
Is covid still deadlier than the flu in 2023?

The short answer is yes

New from our team in @JAMA_current

By @Biostayan Taeyoung Choi and @zalaly

A thread 🧵

jamanetwork.com/journals/jama/…
In this study of 11,399 people

8996 hospitalized for COVID-19 & 2403 hospitalized for flu

5.9% died in the COVID-19 group vs 3.7% died in the flu group

That is a difference of 2.23% deaths

This translates into 60% higher risk of death in COVID vs flu

jamanetwork.com/journals/jama/…
The 60% higher risk of death in people hospitalized for COVID vs flu should be interpreted in the context of 2-3 times more hospitalization for covid than hospitalization for flu

This compounds the rates of death due to COVID vs flu

jamanetwork.com/journals/jama/…
Read 7 tweets

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