Ziyad Al-Aly, MD Profile picture
Physician-Scientist | Studying Long Covid #LongCovid
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Jan 15 9 tweets 9 min read
The latest from our team in @TheLancetEndo

We know that SARS-CoV-2 infection may lead to metabolic disturbances including increased risk of diabetes in #LongCovid

But does it also increase risk of high cholesterol?

by @evanjxu @Biostayan @zalaly

thelancet.com/journals/landi… In this study of 4.9 million people

51,919 with COVID-19
2.6 million contemporary controls, and
2.5 million historical controls

We show an increased risk of cholesterol abnormalities in the post-acute phase of COVID-19

thelancet.com/journals/landi…
Jan 13 4 tweets 4 min read
Outstanding and comprehensive review of #LongCovid

A tour de force by the exceptional @ahandvanish @LisaAMcCorkell @julialmv @EricTopol who are in my view the true heroes of this pandemic

In @NatureRevMicro

nature.com/articles/s4157… Progress has been made over the past 3 years.

But challenges remain and must be urgently addressed.

Understanding #LongCovid will help us

a. understand the other infection-associated chronic illnesses
b. prepare us better for the next pandemic

nature.com/articles/s4157…
Nov 30, 2022 7 tweets 2 min read
My comments to NBC News were misinterpreted.

I am absolutely NOT giving up on the prospects of finding treatment for Long Covid

Absolutely NOT!

nbcnews.com/health/health-… We need to prevent as much Long Covid as possible.

The best way to prevent Long Covid is to:

a. not get covid in the first place (prevent infection and reinfection)
b. vaccines
c. antivirals in the acute phase (paxlovid, etc.).
Nov 10, 2022 13 tweets 9 min read
Here is the latest from our team in @NatureMedicine

Should you protect yourself from Covid-19 reinfection

Yes!

Reinfection is not benign; it is best to avoid it

by @BCBowe @Biostayan @zalaly

A thread 🧵

nature.com/articles/s4159… In this study of 5.8 million people

41k with reinfection

444k with 1 infection (no reinfection)

5.3 million non-infected controls

Compared to no reinfection, reinfection increased risk of death, hospitalization, and other adverse health outcomes

nature.com/articles/s4159… Image
Nov 5, 2022 12 tweets 7 min read
The high & growing toll of #longCOVID calls for an urgent need to understand how to prevent and treat it

The care needs of people with long COVID must be addressed

Comment in @NatRevNeph by @anupamuab @Dr2NisreenAlwan @valerie_luyckx and me

nature.com/articles/s4158…

🧵 The patient community who, to their credit, first recognized and reported this new syndrome used the term ‘long COVID’ to describe the post-acute and chronic sequelae of SARS-CoV-2 infection

#LongCovid

nature.com/articles/s4158…
Sep 22, 2022 16 tweets 10 min read
The latest from our team in @NatureMedicine

The long-term neurologic consequences of #COVID19

A thread 🧵

nature.com/articles/s4159…

by @evanjxu @Biostayan @zalaly In this study of 11.6 million people:

154k with COVID-19,
5.6 million contemporary controls, and
5.8 million historical controls

We show increased risk of an array of post-acute neurologic disorders

nature.com/articles/s4159…
May 25, 2022 16 tweets 8 min read
The latest from our team in @NatureMedicine

Does vaccination protect from #LongCovid?

Vaccines modestly reduce but do not eliminate risk of Long Covid

@VAResearch @vahsrd @WUSTLmed @WUSTLnews @VREFSTL

@Biostayan @BCBowe

nature.com/articles/s4159…

A thread 🧵 In this study of more than 13 million people

Long Covid after breakthrough infection (vaccinated people who subsequently got SARS-CoV-2 infection) is indistinguishable in terms of clinical features from Long Covid in unvaccinated people

nature.com/articles/s4159…
Mar 21, 2022 15 tweets 8 min read
Can Covid-19 lead to diabetes?

New from our team on risk and burden of diabetes in Long Covid at 1 year

In @TheLancetEndo

@VAResearch @vahsrd @WUSTLpubhealth @WUSTLmed @WUSTLnews @VREFSTL

@Biostayan

A thread 🧵

thelancet.com/journals/landi… In this study of more than 8.5 million people: 181 k with COVID-19 and more than 8 million controls without evidence of infection

We show increased risk of new onset diabetes at 1 year

thelancet.com/journals/landi…
Feb 7, 2022 12 tweets 7 min read
The latest from our team on the long-term cardiovascular consequences of Covid-19 in @NatureMedicine

@VAResearch @vahsrd @WUSTLpubhealth @WUSTLmed @WUSTLnews @VREFSTL @NaturePortfolio

@Biostayan @BCBowe

A thread

nature.com/articles/s4159… In a cohort of more than 153 k people with COVID-19, 5.6 million contemporary controls, and 5.8 million historical controls without evidence of infection

We show increased risks of a wide range of cardiovascular diseases at 1 year
Sep 1, 2021 9 tweets 9 min read
The latest from our team:

A deep dive into the long-term consequences of #COVID19 on kidney function and disease

#longcovid #PASC

@VAResearch @vahsrd @WUSTL @WUSTLpubhealth @WUSTLmed @WUSTLnews @VREFSTL
@Biostayan @BCBowe @JASN_News @ASNKidney

jasn.asnjournals.org/content/early/…

🧵 We previously provided a high dimensional characterization of post-acute sequelae of COVID-19

We showed that #LongCovid can affect nearly every organ system.

@Nature @NaturePortfolio

#COVID19 #PASC

nature.com/articles/s4158…
Apr 22, 2021 10 tweets 8 min read
Happy to share the latest paper from our team in @nature

A comprehensive characterization of post acute sequelae of COVID-19

#longcovid #PASC

nature.com/articles/s4158…

@VAResearch @vahsrd @WUSTL @WUSTLpubhealth @WUSTLmed @WUSTLnews @VREFSTL @Biostayan @BCBowe #Longcovid is a multifaceted disease; it can affect multiple organ systems including respiratory, cardiovascular, nervous, mental health, metabolic, gastrointestinal, kidneys, and other organ systems.