Post

More from @ejustin46

Emmanuel

@ejustin46

Apr 1

BRAIN'S BATTLE: 5 Ways COVID-19 Can Disrupt Cognition 😰
1. Persistent neuroinflammation
2. Cerebrovascular complications
3. Direct neuronal injury
4. Activation of the kynurenine pathway
5. Psychological distress

(Visual explanations 💥💯)
onlinelibrary.wiley.com/doi/10.1111/cn…

2) This first figure helps explain the first key mechanisms contributing to cognitive impairment in COVID-19 patients:

▶️ Direct viral entry and brain injury is shown in the first panel.
▶️ The role of hypoxia (lack of oxygen) in cognitive decline is depicted in the second panel

3) ▶️ The widespread systemic inflammation caused by COVID-19 is illustrated in the third panel.

Read 10 tweets

Emmanuel

@ejustin46

Mar 31

For CHILDREN, the risk of LONG COVID after a SECOND INFECTION is 2.08 TIMES GREATER compared to the FIRST INFECTION.
medrxiv.org/content/10.110…

2) Let's summarize first this study :

The researchers used medical records from 40 children's hospitals in the US between January 2022 and October 2023. They compared the risk of long-term issues in those with a second COVID-19 infection versus their first infection.

3) Results showed that children with a 2nd infection had a significantly higher risk of various long-term problems, including:
- Heart issues like inflammation and abnormal heart rhythms
- Changes in taste and smell
- Blood clots
- Kidney problems
- Fatigue and muscle/joint pain

Read 8 tweets

Emmanuel

@ejustin46

Mar 29

What a "CLEVER" SARS-COV-2 virus !
... which induced a P812S mutation in a chronically ill individual, that is somewhat less pathogenic but enables the virus to infect a larger population.
biorxiv.org/content/10.110…

2) This study looks at how a single mutation, called P812S, in the SARS-CoV-2 virus can have different effects. The P812S mutation was found in a person with a long-term COVID-19 infection.

3) The study found that the P812S mutation:
- Reduced the ability of the virus to enter cells and cause them to fuse together (form syncytia). This is linked to less severe COVID-19 disease.
- Helped the virus evade antibodies that target the fusion peptide region of the spike.

Read 6 tweets

Emmanuel

@ejustin46

Mar 29

INSIDE a COVID-19 crashing WAVE (Nov. 2023 and Mar. 2024, coastal Kenya) 🌊

Fascinating information on variants, symptoms, reinfections, ...
Thanks @siamosolocani
for the study medrxiv.org/content/10.110…

2) The study examines the genomic and clinical epidemiology of a SARS-CoV-2 wave that occurred in coastal Kenya between November 2023 and March 2024. Key findings include:

- The wave was dominated by the XBB.2.3-like and JN.1-like Omicron subvariants ...

3) ... which were introduced through multiple independent events, primarily from North America and Europe.

- Genomic surveillance revealed at least 38 separate virus introduction events into the local population during this wave.

Read 9 tweets

Emmanuel

@ejustin46

Mar 28

SHOCKING DECLINES in Key IMMUNE CELLS Months AFTER COVID-19 INFECTION !

Let's aim to offer specific data rather than just stating that "COVID-19 weakens the immune system"
onlinelibrary.wiley.com/doi/10.1111/al…

2) Here are the significant reductions in multiple key immune cell populations at 10 months after initial COVID-19 infection :

▶️ Total leukocyte (white blood cell) counts were reduced by 12%
▶️ Neutrophil counts were reduced by 11%
▶️ Monocyte counts were reduced by 10%

3) ▶️ Total lymphocyte counts were reduced by 14%
▶️ T cell counts were reduced, with CD4+ T cells down 16% and CD8+ T cells down 18%
▶️ B cell counts were reduced by 14%
▶️ Natural killer cell counts were reduced by 19%

Read 5 tweets

Emmanuel

@ejustin46

Mar 28

How SARS-CoV-2 virus changed over 14 months in a patient with a weak immune system ?

The patient was first infected with the B.1.160 variant, then later got infected with the B.1.1.7 variant. The virus kept changing and evolving inside this patient's body biorxiv.org/content/10.110…

2) The virus mutated and recombined, creating new versions of itself. This allowed the virus to adapt and become better suited to the patient's body.

The study found that the virus evolved faster inside this patient compared to how it usually evolves in the general population.

3) This is because the patient's weak immune system allowed the virus to keep changing and trying out new mutations.

Some key mutations were found in genes like Spike, N, ORF9b, and nsp13. These mutations helped the virus evade the patient's immune system and replicate better.

Read 6 tweets

Share this page!

Enter URL or ID to Unroll

Emmanuel

Try unrolling a thread yourself!

More from @ejustin46

Emmanuel

Emmanuel

Emmanuel

Emmanuel

Emmanuel

Emmanuel

Did Thread Reader help you today?

Don't want to be a Premium member but still want to support us?

Send Email!