Post

More from @ejustin46

Emmanuel

@ejustin46

Mar 6

IMAGINE You're a SNEAKY SARS-CoV-2 VIRUS :
How You’d Use Blood Vessels to ATTACK the HUMAN BRAIN, Create Chaos, and Confuse the Brain’s Cleanup Crew!

An Informative EXPLANATION based on 3 recent studies, FOR KIDS and EVERYONE !

2) Imagine Our Body as a Big City:

In this city, blood vessels act like roads, allowing cars (our blood cells) to travel everywhere. Sometimes, bad guys called viruses, like SARS-CoV-2, sneak into this city.

2) ▶️ Getting In:

Think of the SARS-CoV-2 virus as a clever thief. It uses the roads (blood vessels) to reach important areas, like the brain. It carries special keys called spike proteins that help it unlock doors in the blood vessel walls to enter.

Read 10 tweets

Emmanuel

@ejustin46

Mar 6

H5N1 ALARMING ADAPTATIONS:
How Mutations in the Bird Flu Virus are Enabling Spread Between Animals and Posing Grave Pandemic Threat to Humans
(Thanks to @greg_folkers for this new study in Nature)
nature.com/articles/s4146…

2) The H5N1 bird flu virus spread quickly along the coast of Chile, infecting wild birds, farm chickens, and sea animals like seals and dolphins.

The virus came from Peru and then moved south through Chile. Importantly, the virus changed in a way that helps it infect and ...

3) ... spread between mammals, including humans.

Specifically, the virus developed mutations in a gene called PB2. These PB2 mutations allow the virus to replicate better and cause more severe illness in mammals.

Read 6 tweets

Emmanuel

@ejustin46

Mar 6

Unlocking the GENETIC SECRETS BEHIND SEVERE COVID-19 and LONG COVID

An allele is a different version of a gene. Genes are the instructions in our cells that tell our body how to work. But sometimes there are small differences ...
medrxiv.org/content/10.110…

2) ...in these instructions, and those different versions are called alleles.

This study found that a gene called MTHFR affects how sick people get from COVID-19.

Fig.1. Plasma metabolomics of COVID-19 patients reveals one-carbon metabolism association with COVID-19 severity

3) MTHFR has different versions, called alleles.
People with a certain MTHFR allele had higher levels of chemicals related to how cells use one-carbon.

Fig. 2. Relative changes in methionine metabolism are correlated with COVID-19 severity

Read 6 tweets

Emmanuel

@ejustin46

Mar 4

Exploring the Persistence of the Spike Protein along the Skull-Meninges-Brain Axis and the Neurological Effects of COVID-19

This analysis is supported by numerous videos and illustrations.
First, let's identify the location of the skull-meninges-brain axis. Here it is 👇

2) Here is where Spike protein persists in skull marrow, meninges, and brain, accumulating in the recently discovered skull-meninges connections 👇

3) Here are the confoncal images showing SARS-CoV-2 spike and nucleocapsid proteins in skull marrow and meninges of COVID-19 patients, indicating viral presence in these brain border regions.

Read 11 tweets

Emmanuel

@ejustin46

Mar 4

Variations in HLA Genes Influence SARS-CoV-2 Infection Risk for People with HIV, Highlighting Importance of Immune Factors

(What if life wasn't so straightforward? 🤗)
cell.com/iscience/fullt…

2) The links between HIV and SARS-CoV-2 highlighted in this study are:

▶️ People living with HIV often have altered T cell responses compared to those without HIV, including lower T cell counts, decreased T cell receptor diversity, and functional changes in CD8+ T cells.

3)▶️ This study found that people living with HIV on antiretroviral therapy still mounted robust T cell responses to conserved regions of the SARS-CoV-2 virus, even if they had not been previously infected with COVID-19.

Read 11 tweets

Emmanuel

@ejustin46

Mar 3

Captivating Microscopy Illuminates How SARS-CoV-2's E and 3a Proteins Hijack Cellular Pathways to Fuel Viral Replication

(Stunning visuals in this article 💥💯)

Fig. Transfected SARS-CoV-2 E protein plasmids in Caco-2 cells stained with Strep antibody link.springer.com/article/10.100…

2) The SARS-CoV-2 virus has two important proteins called E and 3a. These proteins help the virus infect cells and make more copies of itself.

Figure 1 shows that the E and 3a proteins have a similar structure across different variants of the SARS-CoV-2 virus.

2) This suggests they may have similar functions.

The E protein forms a pentagon shape (Fig. 1C), while the 3a protein has three parts that span the cell membrane (Fig. 1D). These structures allow the proteins to interact with and change the cell's environment.

Read 7 tweets

Share this page!

Enter URL or ID to Unroll

Emmanuel

Try unrolling a thread yourself!

More from @ejustin46

Emmanuel

Emmanuel

Emmanuel

Emmanuel

Emmanuel

Emmanuel

Did Thread Reader help you today?

Don't want to be a Premium member but still want to support us?

Send Email!