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Emmanuel Profile picture
@ejustin46
Jan 23, 2024 • 10 tweets • 4 min read • Read on X
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SARS-COV-2 INFECTS your HEART, BRAIN and OTHER ORGANS

(mega-thread COVID & ORGANS) Image
2) "Organ Involvement in COVID-19: A Molecular Investigation of Autopsied Patients"
mdpi.com/2076-2607/10/7…
Image
3) "SARS-CoV-2 Systemic Effects: New Clues"
mdpi.com/2076-2607/11/5…
Image
4) "Molecular Structure, Pathophysiology, and Diagnosis of COVID-19"
researchgate.net/publication/34…
Image
5)" Extrapulmonary manifestations of COVID-19" nature.com/articles/s4159…
Image
6) "One disease, many faces-typical and atypical presentations of SARS-CoV-2 infection-related COVID-19 disease"
wjgnet.com/2307-8960/full…
Image
7) "Systemic and organ-specific immune-related manifestations of COVID-19"
nature.com/articles/s4158…
Image
8) "From Cell to Symptoms: The Role of SARS-CoV-2 Cytopathic Effects in the Pathogenesis of COVID-19 and Long COVID"
mdpi.com/1422-0067/24/9…
Image
9) Infographic: Bodily Systems Affected by Long COVID
the-scientist.com/infographics/i…
Image
10) Thanks for reading 🙏

(Illustration: V. ALTOUNIAN/SCIENCE) Image

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More from @ejustin46

Emmanuel Profile picture
Jan 5
Why are we experiencing a PROLONGED "POLYPANDEMIC" CRISIS?
(2nd part)

How Animal Viruses Threaten Human Health and Why We Must Protect Ourselves from Zoonotic Infections ?
nature.com/articles/s4156…Image
2) The study identifies key animal viruses that may pose zoonotic risks to humans. It emphasizes that viruses with broad human cell tropism, particularly those from non-human mammals like bats and rodents, show potential for cross-species transmission. Image
3) Over 70% of receptor-binding proteins (RBPs) tested came from these non-human sources. Additionally, emerging viruses such as Sinu virus and Wellfleet Bay virus can enter human cells, indicating the need for monitoring. Image
Read 4 tweets
Emmanuel Profile picture
Jan 4
Main CONCERN for the FUTURE : CO-INFECTION of VIRUSES, BACTERIA and FUNGI 💣
(mega-thread🧵 of the last 10 studies posted for 6 months) Image
2)
3)
Read 11 tweets
Emmanuel Profile picture
Jan 3
SARS-COV-2, the "STEALTH VIRUS"

An interesting and simple 😂😂😂 study sent by my friend David Joffe :
"Regulation of N-degron recognin-mediated autophagy by the SARS-CoV-2 PLpro ubiquitin deconjugase"

(Summary in layman's terms in this post 😂) tandfonline.com/doi/full/10.10…Image
2) The SARS-CoV-2 virus has an ENZYME called PLpro that can remove 'tags' (called ubiquitin) from host proteins, preventing them from being broken down. The study found that PLpro INTERACTS with enzymes that MARK certain PROTEINS for DESTRUCTION. Image
3) By keeping these tagged proteins from being broken down, PLpro can change how the cell recycles and gets rid of proteins. This affects a process called AUTOPHAGY, which the virus uses to modify the cell's internal structures and HIDE from the IMMUNE SYSTEM. Image
Read 4 tweets
Emmanuel Profile picture
Jan 1
BREAKING NEWS 2025 💣💯

SARS-CoV-2 variants are not simply competing with each other, but are in fact WORKING TOGETHER in a COOPERATIVE MANNER !!! 🤔
pmc.ncbi.nlm.nih.gov/articles/PMC10…Image
2) This study looked at how different versions of the COVID-19 virus, called variants, have evolved over time. The researchers found that these variants are not just competing with each other, but are actually working together. Image
3) As new variants emerge, they take in and use the genetic changes (mutations) from previous variants, rather than completely replacing them. This suggests the variants are building on each other's changes, not just trying to beat each other. Image
Read 8 tweets
Emmanuel Profile picture
Dec 31, 2024
WHAT IF TOMORROW, HUMANS were the ONES INFECTING other MAMMALS with H5N1?

The study found that the H5N1 virus isolated from a human dairy worker in Texas (rHPHTX) had mutations that enhanced its replication and pathogenicity (100% mortality) in mammals !
tandfonline.com/doi/full/10.10…Image
2) The study describes the rescue and characterization of recombinant influenza A(H5N1) viruses isolated from infected cattle and a human dairy worker in Texas. The human-origin virus (rHPhTX) had several unique amino acid substitutions compared to ... Image
3) ...the cattle-origin virus (rHPbTX), particularly in the polymerase and nonstructural proteins.

In vitro, rHPhTX replicated more efficiently than rHPbTX in mammalian and avian cell lines, despite similar antiviral susceptibility. Image
Read 6 tweets
Emmanuel Profile picture
Dec 31, 2024
H5N1. LET'S BE READY !

Harnessing the Power of Human B Cells: A Rapid Antibody Engineering Platform to Arm Against Emerging H5N1 Threats
biorxiv.org/content/10.110…Image
2) The CODE-HB platform offers a powerful approach to rapidly evolve improved antibodies targeting emerging infectious threats like H5N1 influenza. By harnessing the natural somatic hypermutation mechanisms of human B cells, the researchers demonstrated the ability to ... Image
3) ...evolve variants of the CR9114 antibody with enhanced binding to the H5 hemagglutinin protein from H5N1 strains.

H5N1 poses a major pandemic risk as it can spread from birds to humans. Image
Read 5 tweets

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