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AJ Leonardi, MBBS, PhD Profile picture
@fitterhappierAJ
Jan 26 • 5 tweets • 2 min read • Read on X
I was a fellow at the National Cancer Institute for 4 years in immunotherapy of cancer

They paid for my PhD

I am happy to explain hypotheses for a potential SARS Cov 2 based increased risk of cancer:

1/4
There are multiple ways a virus can cause cancer directly & indirectly

One indirect way is by tempering immunity

The immune system surveils for wayward, cancerous, and precancerous cells, and kills them

SARS Cov 2 ages & dysregulates T cells
2/4
A second broad yet direct category is by Viral Oncogenes or mutagenesis

Some Viruses have proteins that can change expression or function of host genes & accelerate the formation of tumors by preventing cell death

Some viruses cause DNA errors to accumulate
3/4
Cancer is essentially the uncontrollable growth of cells that are unwilling to contextually die

In most cases you need multiple hits to the DNA in order to create a cancer
4/4
There is also a combination of 1 and 2

Poorer immunologic control of Oncogenic viruses

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More from @fitterhappierAJ

AJ Leonardi, MBBS, PhD Profile picture
Jan 24
In 2021 on TWIV, Vincent Raccaniello said my claims of T cell exhaustion risk were "Twitter Science™"

In 2024 I am pleased to see T cell exhaustion is Science™, Nature Immunology™, and Nature Medicine™ Science
Raccaniello is arrogant enough to the extent to reject an accurate scientific hypothesis on twitter and his TWIV podcast to the detriment of the public, without knowing enough about the subject It was completely irresponsible

Are you feigning ignorance? It was a perjorative.
Read 10 tweets
AJ Leonardi, MBBS, PhD Profile picture
Jan 23
Massachusetts General Hospital has declared a critical incident under a "capacity disaster"

Some professors at Harvard assured the crisis phase of covid was over.

I sure would be embarrassed if shown up by someone I keep proclaiming superiority over.

patch.com/massachusetts/…
Especially if I was a wunderkind Harvard professor in Cardiology.

That would mean I know at least as much immunology as a professor of immunology at a state school
Which Mark has the better takes in immunology?
Read 4 tweets
AJ Leonardi, MBBS, PhD Profile picture
Jan 15
Many people are discovering the paradox of how T cells are driving the harm- pathology- in covid-19

This was part of my publication in 2020, I gave the opinion that T cell effector function was harming organs and that it would remain significant on reinfection
Image
Can you all appreciate how much I was attacked for saying the T cells were harming and responsible for harm? It was relentless. Every Professor with Dunning Kruger went on attack-mode.
What's interesting is that when I am vindicated, it comes in titles from high-impact journals
This one is Science

For some reason the tiniest bit of what some people would call "creative imagination" sends people into a rageful frenzy. Perhaps they lack imagination themselves?
Read 5 tweets
AJ Leonardi, MBBS, PhD Profile picture
Jan 9
People rightfully chafe when sars cov 2 is compared to HIV

The problem is you have allowed denialism to dominate public discussion

When you deny the obvious, you create a vacuum that can be filled with conspiracy theories

4 papers show infection of T cells by SARS 2
1/5
Image
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Even though this is well-published in nature family journals and eLife, empty suits that promised herd immunity by infection deny such a thing is possible.

I am talking about Marc Veldhoen and Antonio Bertoletti

We can see the profound lymphopenia that can occur
2/5
Indeed, T cell differentiation and death was my specialty, and it has become taboo.

Not only that, we have news publications that say "Covid does not harm the immune system*"

"*Unless you have Long Covid."
3/5
Read 5 tweets
AJ Leonardi, MBBS, PhD Profile picture
Oct 23, 2023
As we are hit with yet another Covid wave, I want to reflect on the promises of herd immunity by infection, with special consideration of claims that pre-existing cross-reactive T cell immunity to other coronaviruses was aiding in achieving the herd-immunity threshold
These two circumstances are not unrelated. The reason we are having constant reinfection with sars cov 2 is because we gave the virus the keys to the kingdom: enough replication to enable evolution to escape key parts of our immune systems
In 2020, I warned that resting hopes of herd immunity on T cell immunity was perilous and a bad idea. I said it would enable mutations and evolution of the virus to the extent to facilitate reinfection. Now, this is our reality.
Read 11 tweets
AJ Leonardi, MBBS, PhD Profile picture
Oct 14, 2023
Since 2020 I have claimed that sars cov 2 infection would create harmed t cell memory based on phenotypes after infection

It is now proven

Even so, I have several Professors who pretend to not understand or do not understand how, nipping at my heels

I assume they behave this way because they are tenured & very mad, so they feel they can put their ignorance and vitriol on display wantonly

Bertoletti even made a nod to me in a publication, which the journal maintains references me in no way whatsoever


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For their benefit, I will list the publications that prove my thesis correct:

The first is how T cell responses derived from vaccination are superior to those derived from infection. T cell functions after infection were harmed. The publication is below:
Read 10 tweets

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