Sasha Gusev Profile picture
Jan 29, 2024 11 tweets 4 min read Read on X
So this is pretty typical of the low-information content you get from the genetic racists. The majority of this post is just blather but there is one (1) specific claim about genetics: that the molecular genetic contribution to IQ keeps going up every year. This is false. A 🧵:
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The first study in 2011 into the heritability of IQ using molecular genetic methods found moderately high estimates 40-51%. But this approach was flawed technically (estimator bounds and population structure) and conceptually (environmental confounding). Image
Fast forward to 2023, using hundreds of thousands of people from the UK Biobank, Williams et al. [] ran a battery of analyses to refine a high-quality IQ estimate. The heritability ... 0.20 (with very precise error). pubmed.ncbi.nlm.nih.gov/36378351/
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But this doesn't address the conceptual issue of environmental confounding. For that, Howe et al. used a large-scale within-family analysis, which does a much better job of isolating the genetic component from shared environment. Their estimate of the heritability ... 0.14! Image
So we've gone from 51% to 20% to 14% as the field has learned how to apply these methods more precisely and address confounding. Researchers that raised concerns of environmental confounds and stratification were proven right, and it's unlikely that we've resolved all the issues.
This trend is even more extreme for Educational Attainment, an easier to study trait with more practical relevance. Initial studies had estimates of 22% heritability which decreased to ~15% as better methods and more representative cohorts were applied. Image
When Howe et al. finally employed a proper within-family analysis their estimate of the heritability was ... just 4% (with a tight error bound). That's right, the *entire* common genetic contribution to educational attainment, a major status-driving factor, is a rounding error. Image
So the technical point is flat out wrong. And this style of argument mirrors a general trend. Charles Murray has been promising that his views will be vindicated in "just five years" since 1994!

Steve Hsu has been arguing that a 60% accurate genetic predictor is just around the corner since 2011, and last year declared himself vindicated! (As we just saw, the GWAS heritability of IQ is <14%, it cannot possibly reach 60%)

The shell game they play is: (1) claim that there's *lots* of evidence out there; (2) present one or two sketchy correlations based on bad methods; (3) promise that the better results are just around the corner. In the real world, their position keeps losing. /fin
Sailer tends to disappear whenever he is addressed directly so I'm not hoping for a response. Maybe in a day we'll get another story about sports or movies. But here are a few more unaddressed errors in the whole race/genes/IQ/outcomes project:

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More from @SashaGusevPosts

Oct 14
Eric Turkheimer has a good piece about a bet he made with Charles Murray regarding the genetic understanding of IQ (or, really, the lack of it). Murray being so wrong in his prediction should make us question his world model, but it's also worth commenting on his response. Image
Murray has, for some time now, been workshopping the excuse that progress on IQ genetics was blocked by researchers being denied the access to the relevant databases. This is patently untrue! Image
First, one of the largest genetic analyses to date of *any* trait is of educational attainment, a phenotype Murray himself has used as a proxy for intelligence. Surely a study of 3 million should have been enough to satisfy Murray's prediction.

Read 7 tweets
Sep 18
Murray and most of race twitter has apparently been fooled by this completely fabricated analysis purporting to show African ancestry is associated with IQ. People lie on twitter all the time, but this is both more revealing and more disturbing than usual. A 🧵
Revealing in that it shows how quantitative racism is a just an exercise in manipulating data to fit the preconceived conclusion. Disturbing because this time private data is being used and the results, which cannot be easily verified, are just flatly invented.
What's actually going on? Some guy claims to have an analysis showing that African ancestry differences between siblings are associated with IQ differences in the UK Biobank. Implying an ancestry difference in the within-family influences. Image
Read 24 tweets
Aug 1
A few thoughts on Herasight, the new embryo selection company. First, the post below and the white paper imply that competitors like Nucleus have been marketing and selling grossly erroneous risk estimates. This is shocking if true! 🧵
I wrote last year about the un-seriousness with which Nucleus approached their IQ product and the damage it could do to genetic prediction and research more broadly (). This appears to have been a broader pattern beyond IQ, extending even to rare disease.theinfinitesimal.substack.com/p/genomic-pred…
People who care about this technology should be furious at Nucleus and their collaborators (as well as Orchid and Genomic Prediction for their own errors). Finding such flaws should not require reverse-engineering by a competitor. These products clearly need independent audits. Image
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Read 14 tweets
Jun 24
Oof. Polygenic scores for IQ lose 75% of their explained variance when adding family controls, even worse than the attenuation for Educational Attainment. These are the scores Silicon Valley is using to select embryos 😬.

A few thoughts on this study ...
The TEDS cohort used here is a very large study with high-quality cognitive assessments collected over multiple time points. It is probably the most impressive twin study of IQ to date. That means very little room for data quality / measurement error issues.
It is important to highlight surprising null results. Just last week we were hypothesizing that large IQ score attenuation could be a study bias or an artifact of the Wilson Effect. Now we see it replicate in an independent study with adults.

Read 12 tweets
Jun 11
Racism twitter has taken to arguing that observed racial differences must be "in part" explained by genetic differences, though they demure on how much. Not only is this claim aggressively misleading, it is completely unsupported by data. A 🧵: Image
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Genetic differences between any two populations can go in *either* direction, matching the phenotypic differences we observe or going against them. Genes also interact with the environment, which makes the whole notion of "explaining" differences intractable. Image
The mere fact that a trait is heritable within populations tells us nothing about the explanatory factors between populations. See: Lewontin's thought experiment; Freddie de Boer's analogy to a "jumping contest"; or actual derivations (). pubmed.ncbi.nlm.nih.gov/38470926/Image
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Read 13 tweets
Jun 6
James Lee and @DamienMorris have an interesting perspective paper out describing "some far-reaching conclusions" about the genetics of intelligence. This type of "where are we now" paper is very fun and more people should write them! So, where are we now? 🧵 Image
It's a short paper and it surveys three core findings from the past decade of intelligence genetics. These sections follow a structure that I would cheekily call ... "make a bold claim in the title, then walk it back in the text".
First up, they address the concern that associations with intelligence may actually be mediated by functionally irrelevant traits like physical appearance or pigment. The argument is that IQ GWAS has demonstrated enrichments for CNS/brain structure gene sets. This is true! Image
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Read 19 tweets

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