Share this page!

Enter URL or ID to Unroll

You can paste full URL like: https://x.com/threadreaderapp/status/1644127596119195649
or just the ID like: 1644127596119195649

How to get URL link on X (Twitter) App

  1. On the Twitter thread, click on or icon on the bottom
  2. Click again on or Share Via icon
  3. Click on Copy Link to Tweet
  4. Paste it above and click "Unroll Thread"!
  5. More info at Twitter Help
Emmanuel Profile picture
@ejustin46
Feb 12 • 5 tweets • 2 min read • Read on X
SARS-COV-2 : A MASTER of IMMUNE EVASION using
... "NendoU" ( pronounced nenn-doh-YOU)

What is NendoU ? Image
2) A fantastic article on this topic :

"X-ray light reveals how virus responsible for COVID-19 covers its tracks, eluding the immune system"
news.asu.edu/20230110-xray-…
Image
3) The study :
Summary :
"NendoU from SARS-CoV-2 is responsible for the virus’s ability to evade the innate immune system by cleaving the polyuridine leader sequence of antisense viral RNA"
cell.com/structure/full…
Image
4) Additional reference :
"Crystal structure of Nsp15 endoribonuclease NendoU from SARS‐CoV‐2"
onlinelibrary.wiley.com/doi/10.1002/pr…
5) Thanks for reading and and discovering ? "NandoU" 🤗 Image

• • •

Missing some Tweet in this thread? You can try to force a refresh
　

Keep Current with Emmanuel

Emmanuel Profile picture

Stay in touch and get notified when new unrolls are available from this author!

Read all threads

This Thread may be Removed Anytime!

PDF

Twitter may remove this content at anytime! Save it as PDF for later use!

Try unrolling a thread yourself!

how to unroll video
  1. Follow @ThreadReaderApp to mention us!

  2. From a Twitter thread mention us with a keyword "unroll"
@threadreaderapp unroll

Practice here first or read more on our help page!

More from @ejustin46

Emmanuel Profile picture
Feb 14
ACE2 ORTHOLOGS 🤔

Orthologs are genes that are derived from a common ancestor and perform similar functions in different species Image
2) Interesting study

"We applied this assay to test a panel of 30 ACE2 orthologs or human sequence mutants for infectability by the original SARS-CoV-2 spike protein or the Alpha, Beta, Gamma, Delta, and Omicron BA1 variant spikes." biorxiv.org/content/10.110…
Image
3) Out of the thirteen non-human orthologs, ten exhibited unique patterns of variant-specific compatibility, demonstrating that spike sequence changes during human transmission can toggle ACE2 compatibility and potential susceptibility of other animal species ... Image
Read 4 tweets
Emmanuel Profile picture
Feb 14
CANCER and COVID-19
(Thx to @arijitchakrav for the idea of this mega-thread) Image
2) Increased risks of cancers
3) Lung cancers
Read 9 tweets
Emmanuel Profile picture
Feb 13
SARS-CoV-2: A MASTER of IMMUNE EVASION (2nd part)

"Viruses and their hosts have coevolved for a long time. This coevolution places both the pathogen and the human im- mune system under selective pressure; on the one hand, the immune system has evolved ... ncbi.nlm.nih.gov/pmc/articles/P…
Image
2) ... to combat viruses and virally infected cells, while viruses have developed sophisticated mechanisms to escape recognition and destruction by the immune system."

What are the 7 reported STRATEGIES of SARS-COV-2 which are utilized by SARS-CoV-2 for immune evasion ? Image
3) SPIKE CAMOUFLAGE Employing GLYCAN Molecules (Epitope Masking)
"The RBD is almost fully covered by the glycans in the ‘down state,’ offering a perfect camouflage" Image
Read 10 tweets
Emmanuel Profile picture
Feb 13
KEY STUDY : Viral INFECTION of RENAL CELL TYPES with UNDETECTABLE ACE2 has led to the suggestion of alternate receptors
Proximal Tubule (PT) enhanced organoids show extensive viral entry factor expression journals.asm.org/doi/10.1128/jv…
Image
2) Improved stem cell-derived PT confirms a sole receptor for SARS-CoV-2 entry in renal cells Image
3) SARS-CoV-2 utilizes dual viral entry pathways in renal cells Image
Read 5 tweets
Emmanuel Profile picture
Feb 12
SCIENTISTS Built a CORONAVIRUS From Scratch, Then Saw It TRYING to HIDE

Human cells (green) with synthetic virions (magenta). (MPI for Medical Research/Oskar) sciencealert.com/scientists-mad…
Image
2) The study :
"Synthetic virions reveal fatty acid-coupled adaptive immunogenicity of SARS-CoV-2 spike glycoprotein"

Fig. 1: Bottom-up assembly of minimal SARS-CoV-2 virions. nature.com/articles/s4146…
Image
3) Another excellent article on this topic:

"Stanford Medicine study: SARS-CoV-2 infects fat tissue, creates inflammatory storm cloud"
med.stanford.edu/news/all-news/…
Image
Read 4 tweets
Emmanuel Profile picture
Feb 12
LONG COVID and Alteration of MITOCHONDRIAL RESPIRATION in BLOOD CELLS
sciencedirect.com/science/articl…
2) Mitochondria are the powerhouses of the cells. Mitochondrial respiration refers to the process by which cells generate energy in the form of adenosine triphosphate (ATP) through the oxidation of glucose and other molecules. It plays a crucial role in cellular metabolism Image
3) and overall cellular function.
Peripheral blood mononuclear cells (PBMCS), which include various immune cells, exhibit changes in mitochondrial function in individuals with long COVID.
These alterations in mitochondrial respiration can manifest as decreased ATP production Image
Read 4 tweets

Did Thread Reader help you today?

Support us! We are indie developers!

This site is made by just two indie developers on a laptop doing marketing, support and development! Read more about the story.

Become a Premium Member ($3/month or $30/year) and get exclusive features!

Become Premium

Don't want to be a Premium member but still want to support us?

Make a small donation by buying us coffee ($5) or help with server cost ($10)

Donate via Paypal

Or Donate anonymously using crypto!

Ethereum

0xfe58350B80634f60Fa6Dc149a72b4DFbc17D341E copy

Bitcoin

3ATGMxNzCUFzxpMCHL5sWSt4DVtS8UqXpi copy

Thank you for your support!

Follow Us!

Send Email!

:(