THE CONFUSION between a R0 at 18 for MEASLES and an R0 at 2,5 for WUHAN or at 5, 10, even 20 (in a recent study) for OMICRONS
2) The basic reproduction number R0 is when one person develops an infection and passes it to 1, 2, 10 or 18 persons. It is relevant in a population with no immunity as for example, people not vaccinated against measles.
3) When widespread immunity starts to develop, we will use the Re effective reproduction number or Rt.
Re is the number of people in a population who can be infected by an individual at any specific time. It changes as the population becomes more or less immunized.
3) If the R0 of Wuhan strain was estimated a 2.5, with the increasing immune escape of Omicrons, it is increased to nearly 8.
4) In a recent study, they even estimated the R0 of Omicron at 20.
5) But, once again, due to the level of immunity of a part of the population, what is interesting for COVID-19, is the Re which depends in a country on the average level of immunity of the population.
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Why is Identifying "Non-Trivial SARS-CoV-2 Population Structure within Hosts" Important for Understanding SARS-COV-2 Evolution and the Emergence of New Variants?
2) The "non-trivial population structure" refers to the viral population within a host consisting of two or more distinct, independently evolving subpopulations, rather than a single, homogeneous population.
3) The key points about non-trivial population structure are:
▶️ It was relatively common, found in 5 out of the 9 chronic SARS-CoV-2 infection cases examined.
▶️ It was more prevalent in severely immunocompromised individuals compared to those not significantly immunocompromised
2) Viruses are not living things. They are tiny particles that can only make copies of themselves inside the cells of living things, like humans. When a virus makes copies of itself, it doesn't always make perfect copies.
3) Sometimes, little mistakes happen, and the new virus has a small change, or mutation, in its genes.
Most of the time, these mutations don't do anything useful for the virus. But every now and then, a mutation might happen that makes the virus better at infecting people.
2) This study looks at the risks of COVID-19 for people traveling to space.
Space travel is becoming more common, with over 600 people having gone to space. But COVID-19 could be a big problem for astronauts in the unique environment of space.
3) The study aims to understand how COVID-19 might behave differently in space compared to on Earth.
The researchers reviewed studies on other airborne diseases in space. They found that some diseases, like Epstein-Barr virus and Serratia bacteria ...
From Lung Damage to Gut Dysbiosis:
The Lasting Implications of SARS-CoV-2 Variant-Specific Microbiome Changes (From Wuhan strain to Omicron) labanimres.biomedcentral.com/articles/10.11…
2) The Wuhan strain of SARS-CoV-2 caused serious damage to the lungs of infected mice. The mice had a very high chance of dying from this strain. The researchers also looked at the bacteria in the lungs and guts of the infected mice.
3) The Wuhan strain increased harmful bacteria like E. coli in the lungs. This can make the lungs more prone to other infections.
The Omicron variant caused different changes in the gut bacteria of the mice. It increased certain bacteria linked to inflammation in the gut.
What are GAMMA CORONAVIRUSES ?
And why did we decide to talk about it?
2) A brief reminder :
▶️ SARS-CoV-2 belongs to the family Coronaviridae, is classified as a coronavirus and is responsible for COVID-19
▶️ Bird Flu refers to various strains of the influenza virus, particularly those in the Orthomyxoviridae family including H5N1 and H7N9.
3) ▶️ Gammacoronavirus belongs to the family Coronaviridae like SARS-COV-2.
Some notable gammacoronaviruses include:
- Infectious Bronchitis Virus (IBV): A major pathogen in poultry responsible for respiratory disease and reduced egg production.
A TREATMENT that Could Finally END Long COVID Suffering ?
This isn't the first time a treatment has been announced, and as millions continue to struggle with long Covid, we need to remain both cautious and hopeful 🤗
2) Researchers at WEHI announced that they discovered a new drug that can stop long COVID symptoms in mice. This drug is more effective than the current top treatment, Paxlovid, for both long COVID and acute COVID cases.
3) They focused on a specific protein called PLpro that other treatments haven't targeted well. This breakthrough could lead to new medicines for long COVID, a condition where people continue to feel sick long after their COVID-19 infection.