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Emmanuel Profile picture
@ejustin46
Feb 23, 2024 • 9 tweets • 4 min read • Read on X
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LONG COVID
How SARS-COV-2 "SEEDS" INFECTION from BONE MARROW to the PLATELETS?
(layman terms) Image
2) Bone marrow plays a vital role in the immune system by producing various types of cells. The production of immune cells is essential for maintaining an effective immune response to protect the body and unfortunately these cells in bone marrow are infected by the SARS-COV-2 Image
3) SARS-COV-2 infects macrophages present in bone marrow using a receptor other than ACE2, Neuropilin-1
(We will come back in another thread on the different entries of SARS-COV-2 into cells which cannot be limited to ACE2)
biorxiv.org/content/10.110…
4) "Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity"

"The Role of Neuropilin-1 (NRP-1) in SARS-CoV-2 Infection"
science.org/doi/10.1126/sc…
mdpi.com/2077-0383/10/1…
Image
5) SARS-COV-2 infects also in bone marrow the megakaryocytes. Megakaryocytes are large cells found in the bone marrow that are responsible for producing platelets, which are essential for blood clotting. Image
6) Infection of megakaryocytes which is associated with severe viral infection in COVID-19
sciencedirect.com/science/articl…
Image
7) Megakaryocyte infection which drives the formation of pathogenic afucosylated IgG antibodies
biorxiv.org/content/10.110…
Image
8) If megakaryocytes become infected, they may “seed” infection of the platelets. This could lead to degranulation or deficits in platelet energy metabolism. In addition, because platelets harbor and carry seratonin, platelet infection could contribute to hormonal dysregulation. Image
9) This is key to understand the "SARS-COV-2 persistence and impact LONG COVID megakaryocytes & platelets".

Thanks for reading 🙏
polybio.org/projects/sars-…
Image

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More from @ejustin46

Emmanuel Profile picture
Nov 28
"70% to 90% of our CELLS are completely RENEWED in less than 5 YEARS!
So If we’re mostly "New", why are so many still struggling with SARS-CoV-2?

We will tackle this question, which is more complex than it seems, in several posts. Image
2) First, let's say a few words about cell renewal.
70% to 90% of our cells are renewed over time. This turnover occurs in various cell types, including skin, blood, and immune cells, allowing the body to replace damaged or aged cells.
sciencefocus.com/the-human-body…Image
3) For instance, red blood cells have a lifespan of about 120 days, while skin cells regenerate every few weeks.
Even with significant cell renewal, aging persists due to changes in our DNA.
sciencefocus.com/the-human-body…Image
Read 5 tweets
Emmanuel Profile picture
Nov 26
UNRAVELING CO-INFECTION:
How SARS-CoV-2 and Other Viruses Interact ?
(In layman's terms)

Two groundbreaking studies exploring the complex dynamics of viral co-infection!
biorxiv.org/content/10.110…
biorxiv.org/content/10.110… Image
Image
2) Co-infection occurs when a person is infected by more than one virus at the same time. This can lead to interesting and sometimes complex interactions between the viruses Image
3) In one study about SARS-CoV-2, researchers found that when different versions of this virus infect the same person, they can mix their genetic material through a process called recombination. This means that the new version of the virus can have traits from both parent viruses Image
Read 6 tweets
Emmanuel Profile picture
Nov 24
ENVELOPE PROTEIN and LONG COVID

For more than three years, we have been emphasizing that the envelope protein is an essential component and that we cannot limit our focus to just the spike protein. We are now uncovering its role in long COVID. Image
2) Here are some insights on the E protein and its role in long COVID, as discussed in this recent study.
pmc.ncbi.nlm.nih.gov/articles/PMC12…Image
3) The Envelope (E) protein of SARS-CoV-2 plays a crucial role for several reasons:

▶️ Virus Assembly and Release: The E protein is essential for the virus's assembly and budding from infected cells, contributing to its stability and infectivity.
Read 8 tweets
Emmanuel Profile picture
Nov 21
"N''oubliez jamais" (Never forget - Joe Cocker)🧵

In 2022, COVID-19 was the second leading cause of death globally, with the repercussions of the virus far from over. The lasting impact of the pandemic continues to affect lives around the world.
2)
3)
Read 5 tweets
Emmanuel Profile picture
Nov 20
LONG COVID : Sticky Microclots in the blood !

Recent research may have identified a key factor contributing to long COVID: microscopic clots intertwined with immune system debris in the blood. These unusual structures were found to be nearly 20 times more prevalent ... Image
2) ...in long COVID patients compared to healthy individuals. The clots, associated with neutrophil extracellular traps (NETs), suggest a potential biological marker for persistent symptoms. Image
3) These microclots could impede blood flow in small vessels, leading to issues like brain fog, fatigue, and shortness of breath. Image
Read 4 tweets
Emmanuel Profile picture
Nov 16
Unlocking the Secrets: A Comprehensive Megathread on Key Virus Subtypes of Human and Avian Influenza !"🧵

First, a quick overview of the different subtypes:

HUMAN INFLUENZA
H1N1 : The 2009 pandemic strain, which continues to circulate
... Image
2) H3N2: Strain spreading fast actually and causing significant morbidity
H6N1: Notable for potential human impact.

AVIAN INFLUENZA :
H5N1: High pathogenicity, zoonotic concerns.
H3N8: Emerging strain of interest.
H7N9: Associated with human infections, sporadic outbreaks. Image
3) H5N8: Emerging strain with health implications.
H5N6: Recent cases in birds and humans.
H7N7: Impact on poultry and occasional human cases.
H9N2: Common in birds, history of human infections. Image
Read 12 tweets

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