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Emmanuel Profile picture
@ejustin46
Feb 23, 2024 • 9 tweets • 4 min read • Read on X
Scrolly
LONG COVID
How SARS-COV-2 "SEEDS" INFECTION from BONE MARROW to the PLATELETS?
(layman terms) Image
2) Bone marrow plays a vital role in the immune system by producing various types of cells. The production of immune cells is essential for maintaining an effective immune response to protect the body and unfortunately these cells in bone marrow are infected by the SARS-COV-2 Image
3) SARS-COV-2 infects macrophages present in bone marrow using a receptor other than ACE2, Neuropilin-1
(We will come back in another thread on the different entries of SARS-COV-2 into cells which cannot be limited to ACE2)
biorxiv.org/content/10.110…
4) "Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity"

"The Role of Neuropilin-1 (NRP-1) in SARS-CoV-2 Infection"
science.org/doi/10.1126/sc…
mdpi.com/2077-0383/10/1…
Image
5) SARS-COV-2 infects also in bone marrow the megakaryocytes. Megakaryocytes are large cells found in the bone marrow that are responsible for producing platelets, which are essential for blood clotting. Image
6) Infection of megakaryocytes which is associated with severe viral infection in COVID-19
sciencedirect.com/science/articl…
Image
7) Megakaryocyte infection which drives the formation of pathogenic afucosylated IgG antibodies
biorxiv.org/content/10.110…
Image
8) If megakaryocytes become infected, they may “seed” infection of the platelets. This could lead to degranulation or deficits in platelet energy metabolism. In addition, because platelets harbor and carry seratonin, platelet infection could contribute to hormonal dysregulation. Image
9) This is key to understand the "SARS-COV-2 persistence and impact LONG COVID megakaryocytes & platelets".

Thanks for reading 🙏
polybio.org/projects/sars-…
Image

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More from @ejustin46

Emmanuel Profile picture
Aug 28
IS SARS-CoV-2 BECOMING "INVISIBLE"? The Hidden Truth Behind the Pandemic

As the world strives to move past the COVID-19 pandemic, a troubling narrative has emerged: the perception that SARS-CoV-2 is becoming "invisible." Image
2) Governments and communities are eager to return to normalcy, leading to a tendency to downplay the virus's severity. Reports of new infections and long COVID cases have been totally minimized, creating a false sense of security ...
3) ...that the virus is no longer a significant threat. However, this perception is not only a matter of public sentiment. The virus itself has evolved, most notably with the emergence of the Omicron variant. Recent research reveals that Omicron exhibits a remarkable ability ... Image
Read 10 tweets
Emmanuel Profile picture
Aug 27
Your brain is lying to you !
2) Image
3) Image
Read 6 tweets
Emmanuel Profile picture
Aug 16
VIRUS TEAM-UP:
How SARS-CoV-2 Keeps Cells alive to Spread, Increase Disease Severity and Aid Influenza! 😰
advanced.onlinelibrary.wiley.com/doi/10.1002/ad…Image
2) This research shows that SARS-CoV-2, the virus that causes COVID-19, stops infected cells from dying. Normally, when cells die, it helps stop viruses from spreading. By keeping these cells alive longer, SARS-CoV-2 allows itself to multiply and also helps other viruses ... Image
3) ... like influenza A, grow more easily.
When someone has both SARS-CoV-2 and influenza A, the two viruses can make a person much sicker. The immune system gets overwhelmed, leading to more inflammation and damage to the lungs. Image
Read 4 tweets
Emmanuel Profile picture
Aug 8
ENTROPY UNLEASHED:
How Viral Protein Interactions Drive Coronavirus Adaptation in Bats and Humans

Entropy, in a general sense, refers to the level of disorder or randomness in a system.
biorxiv.org/content/10.110…Image
2) When we talk about protein interactions and viral behavior, entropy can be viewed as a measure of how complex and varied these interactions are.

In the context of the study about coronavirus interactions in bat and human cells, here's a simplified breakdown. Image
3) **Complex Interactions**: The study identifies how proteins from the coronavirus interact with host cells (both bats and humans). These interactions can be highly ordered (low entropy) or more chaotic (high entropy). Image
Read 8 tweets
Emmanuel Profile picture
Aug 5
COVID-19 and/or SARS-CoV-2
(opinion)

Patients care most about how COVID-19 affects their health and daily life, including for those with long COVID. Scientists focus on understanding the virus to find better treatments. Both views are important for dealing with the pandemic. Image
2) I'm bringing up this topic because, after talking so much about the disease, its long-term effects, treatments, and vaccines, many people have forgotten that we are dealing with the most dangerous virus humanity has ever faced.
3) What inspired me is this article about chaos theory and quantum mechanics and how it can help us to better understand SARS-CoV-2

A new study found a way to link them by showing that gravity may come from the disorder or "entropy" of matter and energy.
interestingengineering.com/science/quantu…
Read 10 tweets
Emmanuel Profile picture
Aug 1
INSIDE OUR INFECTED CELLS.
How SARS-COV-2 stealthy hijacks our cellular sanctuaries (organelles) ?
🤓 Visual explanations

Organelles provide the possibility for the virus to organize its RNA in PROTECTED structures, concentrate REPLICATION machinery ...
nature.com/articles/s4146…Image
2) ...compartmentalize the replication process, and hide from immune detection.

Figure 1g - The large perinuclear clusters of viral RNA demonstrate how the viral RNA is organized into PROTECTED structures. Image
2) Figure 3d- The nanoscale puncta of the viral RNA-dependent RNA polymerase (nsp12) within and around the viral RNA clusters show the concentration of REPLICATION machinery. Image
Read 5 tweets

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