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Emmanuel Profile picture
@ejustin46
Mar 6, 2024 • 7 tweets • 3 min read • Read on X
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SARS-COV-2 is AIRBORNE
SOON a VERY INTERESTING STUDY !

▶️ 61% of participants emitted variant-specific culture-positive aerosols <10mum (10 micrometers (um) in diameter) for up to 9 DAYS after SYMPTOM ONSET !

▶️ Considerable heterogeneity in potential infectiousness ...
2) ... i.e., only 29% of participants were probably highly infectious (produced culture-positive aerosols <5mum at ~6 days after symptom onset)."

See you soon 🤗
3)
We finally succeed to open this new study while website was temporary blocked nature.com/articles/s4146…
nature.com
Image
4) We will go directly to the last part which is really interesting :

DISCUSSION
"Our findings indicated that SARS-CoV-2 is culturable from human-generated aerosol <10 μm in almost 60% of affected of the patients evaluated, although some individuals had the capability ... Image
5) ... to aerosolise culturable virus in smaller particles for extended time periods. The ability to aerosolise culturable virus is heterogenous and inversely related to time from symptom onset and modulation of specific components of host immunity. Image
6) Nasopharyngeal Ct thresholds and a preliminary unvalidated blood-based biosignature was highly predictive of infectious aerosol generation. These data support the need for prevention of airborne transmission risk ... Image
7) using better ventilation in public transports, and indoor environments, especially hospitals, workplaces and schools, and the use of other airborne infection controls in health care facilities caring for COVID-19 patients."

Thanks for reading 🙏 Image

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More from @ejustin46

Emmanuel Profile picture
Jan 17
The ENDLESS BATTLE between CORONAVIRUSES (incl. SARS-COV-2) and MAMMALIAN HOST IMMUNITY (incl. Bats)

biorxiv.org/content/10.110…Image
2) Viruses are constantly evolving to evade the immune defenses of their hosts. This is especially true for coronaviruses like SARS-CoV-2, which can infect a wide range of mammals, including humans, cats, dogs, and even bats.
3) Bats are particularly interesting because they can harbor many deadly viruses without getting sick. This is thought to be due to unique features of their immune system. However, the exact mechanisms are not well understood.
Read 7 tweets
Emmanuel Profile picture
Jan 17
H5N1. New key study in Nature! 💥💯

How H5N1 affects monkeys to understand the risk to humans ?
The virus was given to the monkeys in three different ways through the nose, directly into the lungs, and through the mouth.

Thanks to @DavidJoffe64
nature.com/articles/s4158…Image
2) Monkeys given the virus directly into their lungs got very sick, with serious lung damage and the virus spreading to other organs. Monkeys given the virus through their nose also got sick, but not as severely. Image
3) Interestingly, monkeys given the virus through their mouth did not get sick or have the virus spread in their body. This suggests that getting the virus from drinking contaminated dairy products may be less risky than breathing it in. Image
Read 4 tweets
Emmanuel Profile picture
Jan 17
VIRUS-VIRUS INTERACTIONS

Uncovering the Intricate Interplay of Respiratory Viruses: How Influenza's Dominance Shapes the Viral Ecology, Disrupted by the COVID-19 Pandemic
medrxiv.org/content/10.110…Image
2) The key finding of this study is that the COVID-19 pandemic significantly disrupted the typical seasonal patterns and virus-virus interactions among respiratory viruses.

Prior to COVID-19, the respiratory viruses exhibited distinct seasonal peaks with ... Image
3) ... influenza and RSV coinciding in winter, and parainfluenza peaking in summer. This suggested complex interplay between the viruses.

Despite an overall decline in respiratory virus infections during the pandemic, coinfection rates remained remarkably stable at around 10%. Image
Read 7 tweets
Emmanuel Profile picture
Jan 16
▶️HOW the TRANSMISSION BOTTLENECK of SARS-CoV-2 (nb of viruses shed from one host to infect another) AFFECTS VIRAL EVOLUTION?
▶️What ROLE Does DIRECT EXPOSURE Play in VIRUS SHEDDING?
▶️Can the UPPER AIRWAY'S ROLE clarify the IMMUNITY LEVELS needed?
💯💥
science.org/doi/10.1126/sc…Image
2) How the transmission bottleneck affects viral evolution ?

- Wider transmission bottlenecks (more viruses transmitted) can aid viral evolution by:
- Increasing the amount of genetic diversity transferred between hosts Image
3) - Increasing the probability of mixed-strain infections and recombination
- Allowing more efficient selection of fit variants
- Narrower bottlenecks only transfer limited genetic diversity, making it more likely fit variants fail to transmit due to chance Image
Read 7 tweets
Emmanuel Profile picture
Jan 15
SURPRISING DATA 😲 ?

▶️ UNVACCINATED WITHOUT N ANTIBODIES had the HIGHEST RATE of new Omicron INFECTIONS (56%)
▶️ The N ANTIBODY TEST identified 27.3% of POSITIVE who had NEGATIVE PCR RESULTS

onlinelibrary.wiley.com/doi/10.1002/jc…Image
2) The study found that nucleocapsid (N) antibodies were a valuable marker for detecting SARS-CoV-2 infections, including many asymptomatic cases missed by PCR testing. 35.2% of PCR or N antibody positive individuals were asymptomatic, and the N antibody test ... Image
Image
3) ... identified 27.3% of positive HCWs who had negative PCR results.

Potential reasons for the high rate of asymptomatic infections include a genetic basis, with research suggesting the HLA-B*15:01 allele may allow rapid viral clearance before antibody production. Image
Read 5 tweets
Emmanuel Profile picture
Jan 11
SARS-CoV-2 VIRAL PARTICLES CAN PERSIST IN VARIOUS BODILY FLUIDS FOR AN EXTENDED PERIOD AFTER INITIAL INFECTION 😨

H/t @atranscendedman
science.org/doi/10.1126/sc…Image
2) This study uses a microfluidic device which provides an important advance over standard COVID-19 tests by directly detecting intact SARS-CoV-2 viral particles, rather than just free viral RNA. Image
3) The ability to measure whole virus offers insights into active infection and infectivity.

In patient samples, the researchers found detectable levels of SARS-CoV-2 viral particles persisting for weeks after initial diagnosis. Image
Read 7 tweets

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