Thread by @ejustin46

Let's use DEFECTIVE INTERFERING PARTICLES (DIPs) to REDUCE the REPLICATION of SARS-CoV-2 👍

DIPs are virus-like particles that arise during virus growth, fail to grow in the absence of virus, and replicate at the expense of virus during co- infections.

2) DIPs have been studied as potential antiviral agents against a variety of RNA viruses, including influenza, measles, and respiratory syncytial virus (RSV). They have shown promise in both in vitro and animal models, demonstrating their ability to reduce viral replication ...

3) ... and improve disease outcomes.
Here is for example a study about their use against the dengue virus

"Dengue virus-free defective interfering particles have potent and broad anti-dengue virus activity" nature.com/articles/s4200…

4) In 2021, researchers have reported their attempt to engineer TIPs that can conditionally replicate with SARS-CoV-2, inhibit viral replication 10–100 fold.
To this end, the TIPs inhibit the virus through competition for viral replication machinery.

5) In their work, a single dose administration of TIP ribonucleic acid (RNA) was found to inhibit SARS-CoV-2 in continuous cultures.

"Identification of a therapeutic interfering particle—A single-dose SARS-CoV-2 antiviral intervention ... "
sciencedirect.com/science/articl…

6) In a very interesting study just published, they explored "the therapeutic potential of defective interfering particles in reducing the replication of SARS-CoV-2"
biorxiv.org/content/10.110…

6) I find this idea of ​​"parasitizing" the replication of SARS-COV-2 quite fascinating.

Let's DIG into DIPs and TIPs 🤗
maybe a therapy of the future.

Other REFERENCES :
"Evolution of naturally arising SARS-CoV-2 defective interfering particles"
ncbi.nlm.nih.gov/pmc/articles/P…