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Ziyad Al-Aly, MD Profile picture
@zalaly
Mar 15 • 3 tweets • 2 min read • Read on X
The world must not turn its back on people with Long Covid.

Long Covid is a significant global challenge that must decisively addressed.

My statement on #LongCovidAwarenessDay

#LongCovidAwarenessDay #ActOnLongCovid #LongCovid

👇👇 Image
Full text here:

Today, on Long Covid Awareness Day, I want to amplify a crucial message: The world must not turn its back on people with Long Covid.

Long Covid is a significant global challenge that must decisively addressed.

Long Covid transcends borders; it impacts the lives of hundreds of millions around the world and impacts national economies.

Addressing Long Covid requires a coordinated and comprehensive response strategy.

I urge governments worldwide to:

1. Prioritize and fund trials to identify effective Long Covid treatments.

2. Commit to sustained funding for Long Covid research.

3. Train healthcare providers to recognize and effectively manage Long Covid.

4. Launch public education campaigns to raise awareness about Long Covid.

5. Fund services and support systems for those affected by Long Covid and their caregivers.

6. Invest in prevention including clean air technologies, variant-proof vaccines, and vaccines that block infection and transmission.

The world has the means and the obligation to address Long Covid.

Inaction is not an option. Failure is not an option. Now is the time to act!

#LongCovidAwarenessDay #ActOnLongCovid #LongCovid
Where are we on Long Covid and what needs to happen in this thread:


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More from @zalaly

Ziyad Al-Aly, MD Profile picture
Feb 22
📣 New in @ScienceMagazine

I teamed up with @EricTopol to write this #SciencePerspective on Long Covid

Solving the puzzle of #LongCovid

A long 🧵

science.org/doi/10.1126/sc…
First, what is Long Covid?

It is a complex nonmonolithic multisystemic disease with sequelae across almost all organ systems

It can manifest across the life span (from children to older adults) and across race & ethnicity, sex, & baseline health status

science.org/doi/10.1126/sc…
Long Covid is likely a disease with many subtypes that may have different risk factors (genetic, environmental, etc.) and distinct biologic mechanisms that may respond differently to treatments.

science.org/doi/10.1126/sc…
Read 19 tweets
Ziyad Al-Aly, MD Profile picture
Dec 24, 2023
3 key messages from our recent paper in @TheLancetInfDis

1. Covid is worse than flu

Covid remains a much more serious threat to human health than the flu

thelancet.com/journals/lanin…
2. Comparing the two:

COVID is more multisystemic
Flu is more respiratory

thelancet.com/journals/lanin…
3. Both covid and flu cause more health loss in the long-term than what is evident around the time of the infection

Trivializing these illnesses as inconsequential ignores the large burden of health loss that occurs in the post-acute/chronic/long phase

thelancet.com/journals/lanin…
Read 4 tweets
Ziyad Al-Aly, MD Profile picture
Dec 16, 2023
Some people objected to use of the term “long flu”

Let me explain

A thread

thelancet.com/journals/lanin…
Lets start with the evidence about health loss

higher in post-acute flu than acute flu

higher in post-acute covid (long covid) than acute covid

In both acute and post-acute phases, burden of health loss was higher in covid than flu

thelancet.com/journals/lanin…
For me, a big revelation from the study was:

the realization that when you measure it, the burden of health loss is higher in post-acute (long) phase of illness than acute phase of illness

I knew this about covid
I did not know this about flu
Read 10 tweets
Ziyad Al-Aly, MD Profile picture
Dec 14, 2023
📣 New from my team in @TheLancetInfDis

Long-term outcomes of people hospitalized for COVID-19 vs seasonal influenza

A 🧵

thelancet.com/journals/lanin…
The study included:

81,280 individuals hospitalized for SARS-CoV-2
&
10,985 individuals hospitalized for seasonal influenza

We followed them for 1.5 years to characterize the risks of death, health care utilization & 94 health outcomes

thelancet.com/journals/lanin…
Covid had higher risk of death, healthcare utilization and sequelae in most organ systems than flu

This was evident in pre-delta, delta, and omicron; and also evident in vaccinated and unvaccinated individuals.

thelancet.com/journals/lanin…

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Read 9 tweets
Ziyad Al-Aly, MD Profile picture
Aug 21, 2023
1/ 📣 New from my team in @NatureMedicine

In a study of 6 million people, we examined risk trajectories of 80 components of Long Covid over 2 years post-infection

📌 Risks remained elevated for many Long Covid conditions even 2 years infection

A 🧵

nature.com/articles/s4159…
2/ The study included:

138,818 individuals with SARS-CoV-2
&
5,985,227 non-infected controls

We followed them for 2 years to characterize the risk trajectories of death, hospitalization and 80 components of Long Covid

nature.com/articles/s4159…
3/ In people who were not hospitalized during the acute phase of COVID (the majority)

risk of death remained elevated up to 6 months

risk of hospitalization remained elevated up to 19 months

risks remained elevated for 31% of sequelae during the 2-year

nature.com/articles/s4159…
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Read 22 tweets
Ziyad Al-Aly, MD Profile picture
May 10, 2023
My piece in @TheLancetInfDis

Reflections on Long Covid prevention: progress and challenges

A thread

thelancet.com/journals/lanin…
LongCovid does not only affect patients and their life expectancy, but also societal wellbeing and economic indicators (labour participation and economic productivity).

Preventing long COVID should be a public and a global health priority.

thelancet.com/journals/lanin…
All evidence points in the same direction—SARS-CoV-2 antivirals might be important tools for prevention of Long Covid

Paxlovid reduced the risk by 26%

Molnupiravir reduced the risk by 14%

Ensitrelvir may also reduce the risk

thelancet.com/journals/lanin…
Read 12 tweets

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